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Background – While amyloid-β (Aβ) and tau are hallmark pathologies of Alzheimer’s disease (AD), TDP-43 proteinopathy is increasingly recognized as an important contributor, occurring in up to 57% of AD cases and associated with accelerated cognitive decline. TDP-43 regulates RNA splicing, and its mislocalization leads to cryptic exon inclusion and loss of canonical protein function. While neuronal
Forest above-ground biomass (AGB) estimation is crucial for evaluating carbon dynamics. Although optical and synthetic aperture radar (SAR) data provide complementary spectral and structural information, limitations in existing fusion approaches restrict AGB estimation accuracy. This study proposes a multi-source data fusion framework comparing two image fusion strategies—the conventional Hue-Inte
Generative AI promises substantial productivity gains, but many initiatives fail. This column argues that outcomes depend on readiness, not technology alone. We examine AI transformation requirements across organizational, individual, and technological dimensions, highlighting why engineering practices, human factors, and strategic clarity determine success.
Preeclampsia (PE) is a complication during pregnancy characterized by hypertension, organ damage, and systemic inflammation. Increasing evidence suggests that the gut microbiome may play a role in the pathophysiology of PE. However, previous studies on the gut microbiome have generally overlooked the distinction between subgroups of PE, although clinical manifestations may differ. Also, most studi
p27, a cyclin-dependent kinase inhibitor, functions as a tumour suppressor in the nucleus but may acquire oncogenic properties when mislocalized to the cytoplasm. While KRAS mutations can induce p27 phosphorylation and cytoplasmic retention, the regulation and significance of p27 expression in wild-type (WT) KRAS colorectal cancer (CRC) remain unclear. This study investigated the relationship betw
Low- and middle-income countries are expanding health insurance to enhance financial protection. However, there is scarcity of evidence on the stakeholder perceptions towards health insurance. This study explores stakeholders' perceptions towards the implementation of the National Health Insurance Scheme in Zambia. This qualitative study is based on 21 in-depth interviews with key stakeholders inv
BACKGROUND: Improving utilization of contraceptive methods serves as a powerful catalyst for advancing women's education, health, and personal autonomy. Many countries have pledged to enhance contraceptive availability as part of their commitment to the Sustainable Development Goals (SDGs), specifically under indicator 3.7.1. This study sought to understand the drivers of modern contraceptive use
Sexual harassment persists in academic workplaces despite extensive policy frameworks. This study explored how employees at a large Swedish university perceive and articulate the organisational culture and everyday norms that shape sexual harassment. Ten focus group discussions were held with forty staff members, separated by managerial role and conducted in Swedish or English. Transcripts were an
Two protein ingredients, vital wheat gluten (WG) and hempseed protein concentrate (HPC), were extruded both individually and in combination, in a co-rotating twin-screw extruder to produce pilot-scale high-moisture meat analogues. To determine possible textural outcomes, the impact of the ratio between the input materials and operational settings was investigated. Seven different WG and HPC ratios
Offshore wind farms (OWFs) pose a potential threat to migratory birds, either as a barrier or as a result of lethal collisions. We aimed to demonstrate the temporal and spatial frames for potential mitigation measures for a rare and protected species. We analysed 74 autumn migration tracks for 65 GPS-tagged Caspian terns (Hydroprogne caspia) through an area with operating and planned OWFs. On thei
We characterized patients with discordant plasma p-tau217 results and amyloid status determined by the Aβ42/p-tau181 CSF ratio or Aβ-PET biomarkers in an ethnically diverse mixed memory clinic cohort. Among 539 patients, 83.9% had concordant biomarker profiles, while 13.4% were amyloid negative and plasma p-tau217 positive discordant, and 2.8% were amyloid positive and plasma p-tau217 negative dis
Background: The use of patient-reported outcome measures (PROM) can be beneficial in several ways. However, presentations of PROM data from individuals living with, through, or beyond cancer are scarce in the existing scientific literature, and challenges in presenting and interpreting PROM data may be an explanation. Our overall aim was to describe aspects of wellbeing in individuals living with
The paper explores how Indigenous, Black, and Campesinas women in the Colombian Caribbeantransform everyday practices of care into socio-environmental leadership and territorial defence.Based on oral histories collected through collaborative research on water governance and climatechange, we examine how emotions and ecological knowledge converge in defending land, water, andcollective well-being.
Examensarbetets titel: Differentiering inom detaljhandeln: kundperspektiv på alternativutvärderingen mellan detaljhandlare inom hemelektronik Seminariedatum: 5 juni 2026 Ämne/kurs: FEKH29, Examensarbete i marknadsföring på kandidatnivå, 15 hp Författare: Bernard Bezerra, Felix Lindholm Handledare: Annette Cerne Fem nyckelord: Detaljhandel, Hemelektronik, Alternativutvärdering, DifferentieringTitle: Differentiation in retail: A customer-centric perspective on alternative evaluation between retailers in the consumer electronics industry. Seminar date: 5th of June 2026 Course: FEKH29, Degree Project Undergraduate level, Business Administration, Undergraduate level, 15 Credits Authors: Bernard Bezerra, Felix Lindholm Advisor/s: Annette Cerne Key words: Retail, Consumer, Electronics,
Sustainability-oriented firms increasingly operate under conditions of systemic uncertainty, where ecological, commercial, and legitimacy-related pressures converge simultaneously and resist singular strategic resolution. Despite growing scholarly interest in sustainability-oriented Business Model Innovation (BMI), existing research has devoted limited attention to how firms navigate competing sus
Project management office (PMO) maturity models are widely used to assess PMO capability and guide organisational improvement initiatives. However, their ability to capture PMO performance and value delivery remains uncertain, particularly in complex industrial environments where organisational context strongly shapes project work. This study enhances understanding of the extent to which the PMO M
Bakgrund: Arbetsrelaterad stress inom somatisk akutsjukvård påverkar sjuksköterskors förmåga att upprätthålla patientsäkerheten i en miljö präglad av hög arbetsbelastning, tids- och resursbrist samt oförutsägbarhet. Syfte: Att belysa hur sjuksköterskor upprätthåller patientsäkerheten vid arbetsrelaterad stress inom somatisk akutsjukvård. Metod: Sex semistrukturerade intervjuer genomfördes med legi
