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The pattern of fall in B-cell function measured as plasma and 24 h urinary C-peptide excretion, as well as levels of islet cell antibodies, insulin antibodies and metabolic parameters, were followed for two years in 39 children aged 1-17 years prospectively from clinical onset of Type 1 (insulin-dependent) diabetes. At onset 32/36 patients had measurable plasma C-peptide (median 0.13 nmol/l). Maxi

Diabetes was induced in BALB/c mice by four injections of a subdiabetogenic dose (40 mg/kg) of streptozotocin in combination with CFA. The treatment increased the plasma glucose from 5.8 ± 0.1 to 22.1 ± 1.3 mmol/liter (n = 9). The diabetic animals had circulating islet cell surface antibodies (75%), and a monoclonal islet cell surface IgM antibody, K56aF3, generated from one of the diabetic BALB/c

Rwanda har sedan 2006 aktivt arbetat för att modernisera jordbrukssektorn med syftet att ersätta småskaliga självförsörjande jordbruk med moderna, marknadsorienterade. I denna process har småskaliga jordbrukare tvingats att överge sina traditionella grödor och jordbruksmetoder för att anpassa sig till odling i monokultur utvalt av staten på sammanslagna jordlotter.Avhandlingen, baserad på 13 månadSince 2006, Rwanda has been implementing policies to modernize the agricultural sector, with the aim of moving from small-scale subsistence farming to modern, market-oriented farming. Under these policies, small-scale farmers have been compelled to abandon their traditional farming practices and adapt to monocropping of state-approved crops on consolidated land.This dissertation, based on 13 month

Background: Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations. Methods: This observational study included data from the Optimum Patient Care Research

This book offers a unique analysis of the use of the automated facial recognition algorithms that are increasingly intervening in our society from a critical visual culture studies perspective. The discussion focuses on the visuality of automated facial recognition and its designed algorithms as a case study in machinic vision and its concurrent modes of perception. It focuses on a general problem

Bacteriophages, or phages, are viruses that infect bacteria, at the end of their life cycle produce a set of enzymes called endolysins to lyse host cells from within, facilitating the release of the viral progeny. Due to their lytic activity, endolysins have gained great interest as potential antibacterials targeting both Gram–positive and –negative bacteria, especially in the actual context of in

Den statliga förvaltningen i dess olika skepnader har sedan länge mycket stor betydelse för samhället och enskilda i de nordiska länderna. En central fråga i offentlig rätt och statsvetenskap är hur förvaltningens ställning i samhället ska förstås. I ett offentligrättsligt perspektiv handlar det då bland annat om förvaltningens konstitutionella eller statsrättsliga roll. Hur fastställs de rättslig

Background: Health professions education programs are tasked with designing curricula to effectively andefficiently equip their graduates with the required competences and life-long learning skills needed fortoday’s fast-paced, knowledge intensive society. Continuous monitoring and improving of educationalquality is essential to attain these goals. Quality assurance is multi-faceted and requires t

Background: The power and influence of the hidden curriculum - culturally situated norms and values - onlearning opportunities is a growing concern in medical education. However, while medical schools producediversity and equal treatment policies, efforts towards surfacing and addressing equal opportunities in theclinical learning environment trail behind.Summary of Work: To better understand how

The development of tools to help cities and water utility authorities communicate and plan for long-term sustainable solutions is of utmost importance in the era of a changing and uncertain climate. This study introduces a hybrid modeling concept for the cosimulation of mesoscale blue-green stormwater systems and conventional urban sewer networks. The hybrid model successfully introduces the reten

We report on the straightforward metal-free synthesis of poly(p-terphenyl perfluorophenylsulfonic acid)s by efficient superacid catalyzed Friedel–Crafts polycondensations of commercially available perfluoroacetophenone and p-terphenyl, followed by sulfonation of the pendant pentafluorophenyl groups via a selective and quantitative thiolation-oxidation procedure. The stiff and well-defined polymer

Background: Inflammatory bowel disease (IBD) is a chronic, inflammatory relapsing disease with increasing incidence. IBD research and long-term follow-up of patients have, however, been hampered by lack of detailed data on disease phenotype, patient-reported outcome measures, Physician Global Assessment, disease activity, and hospital-administered drugs. Aim: To review the Swedish IBD quality regi