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Cancer is a disease condition where the cells proliferate uncontrollably leading to organ failure, metabolic collapse (cachexia), chronic inflammation combined with immune dysregulation, and many more. Out of the most prevailing cancers, breast cancer ranks second in the world of which 75% are diagnosed with hormone-dependent breast cancers. Bile Salt Stimulated Lipase(BSSL), a lipolytic enzyme se
This thesis seeks to answer the question of whether obligations to primary pandemic prevention and bio-risk management can be derived from the human right to health. The definition of the right to health in Article 12 of the International Covenant on Economic, Social, and Cultural Rights (ICESCR) was selected, as it is the broadest definition of the right to health in international human rights la
Major depressive disorder (MDD) is a prevalent psychiatric condition and poses a significant burden on public health. The underlying causes and mechanisms of depression remain poorly understood. There is a growing body of evidence linking microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal relationship between miRNAs and MDD remains unclear. This study aimed to investigate t
Ovarian cancer remains a significant challenge in oncology, with current treatments having a high recurrence rate making further investigations into treatment targets and the heterogeneity of cancers necessary. As findings from cell lines models are hard to transfer to in vivo cancers, we wanted to explore possibilities to better integrate cell line and tissue omics data. To do so, this study leve
The composition of the tumour microenvironment has been reported as a meaningful predictor in triple-negative breast cancer’s (TNBC) prognosis and response to treatment and has allowed for implementation of new therapeutic approaches such as immunotherapy. Therefore, new spatially resolved approaches have arisen recently to unravel the properties of the microenvironment, ranging from spatial trans
Over recent years, mass spectrometry has become essential for advancing proteomics. A typical approach in proteomics involves digesting proteins into peptides, analyzing these peptides using liquid chromatography and mass spectrometry (LC-MS), and identifying them via tandem mass spectrometry (MS/MS). In Data-Dependent Acquisition (DDA), quantification is often achieved by counting MS/MS spectra o
High-grade serous carcinoma (HGSC) accounts for most ovarian cancer deaths, due to it often being diagnosed at late stages (III and IV). However, there is currently no early screening method sufficient for improving survival rates. HGSC primarily harbors structural variants, typically copy number (CN) aberrations caused by homologous recombination deficiency (HRD). CN can be calculated based on re
Antibodies are crucial components of the humoral immune responses, and their therapeutic potential is gaining attention. For antibodies to be effective, it is essential that they exhibit specificity towards antigens, mediate biological functions and are administered at the correct dosage. Given the numerous parameters influencing specificity, function, and optimal concentration, assessing what con
Recent studies have documented large declines in the abundance and diversity of a few well-studied groups of organisms. However, it is unclear how representative the results are for other, less studied groups such as spiders and other ground-dwelling arthropods. A few recent studies have reported large declines in spider abundance, but these have been performed in highly disturbed settings, and ma
The Baltic Sea is heavily affected by invasive alien species (IAS). One of them is the round goby (Neogobius melanostomus) derived from the Ponto-Caspian Seas and is currently affecting the Baltic Sea coastal ecosystem by altering food webs and competing with native benthic fish. The round goby has become a regular part of the diet in predatory fish such as Eurasian perch (Perca fluviatilis) and P
Like many waterfowl and wader species, Kentish Plovers Charadrius alexandrinus of both the north-west European and Wadden Sea populations perform a post-breeding moult before migrating to their southerly wintering grounds. They make use of specific moulting sites, e.g. in the Dutch Delta area, on Fanø in the Danish Wadden Sea and on the sandbars off St. Peter-Ording in the German Wadden Sea. In or
This thesis aims to compare the user experience of an alarm system, which in- cludes a conventional alarm list, with newly developed graphical ways to display alarms. In addition to these visual enhancements, new features requested by users, such as the ability to park alarms to minimise the overwhelming feelings during an alarm flood were integrated. Three iterations with usability tests were con
Sharks are an ecologically important group of fishes important to maintaining ecosystem structure and function, yet the additive effects of climate change and anthropogenic activities threaten their survival. Northwestern Atlantic populations of shortfin mako sharks and white sharks are considered threatened species, with populations in decline since the 1950s. Previous conservation efforts have a
Broadleaved deciduous forests have endured a far-reaching process of fragmentation. This has resulted in different configurations of remaining habitats with many times unknown consequences for species persistence. To reduce the potential negative effect, frameworks such as the concept of green infrastructure have been implemented with a focus on increasing connectivity in urban and rural planning.
Uganda’s natural resource base is one of the richest and most diverse in Africa. People’s livelihoods are inextricably linked to sound natural resource management and both water and land are basic resources for virtually all socio-economic activities. Because of the significance of agriculture to rural livelihoods, water and land are the most important assets for many households. Located in a tran
What does Gen Z (those born 1995-2010) and Denmark have in common? Chlamydia. Denmark reports the highest chlamydia rates in Europe among individuals aged 15–29, with the number increasing since 2012. Despite the availability of free sexually-transmitted infection (STI) testing and comprehensive sexual education, rates continue to rise. The underlying causes of this trend need investigation, part
This study examines the relationship between ethnic school segregation and reading performance among second-generation migrant students compared to natives in Denmark and Sweden, using PISA 2015 data. The research explores how different integration policies influence educational outcomes in the context of ethnic segregation. Findings reveal that higher proportions of migrant students in schools ne
