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Background: Cluster analyses have proposed different diabetes phenotypes using age, BMI, glycaemia, homoeostasis model estimates, and islet autoantibodies. We tested whether comprehensive phenotyping validates and further characterises these clusters at diagnosis and whether relevant diabetes-related complications differ among these clusters, during 5-years of follow-up. Methods: Patients with new
The mass spectrometry (MS)-based analysis of free polysaccharides and glycans released from proteins, lipids and proteoglycans increasingly relies on databases and software. Here, we review progress in the bioinformatics analysis of protein-released N- and O-linked glycans (N- and O-glycomics) and propose an e-infrastructure to overcome current deficits in data and experimental transparency. This
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opp
Frågan om ”familjens” existens inom sociologin, som teoretiskt begrepp, variabel och empiriskt studieobjekt har debatterats livligt under många decennier. I detta kapitel vill jag argumentera för betydelsen av kritisk sociologi om familj och nära relationer; forskning som ser ”familjen” som ett centralt begrepp i samhället och i människors sätt att leva och skapa mening kring sina liv, och som sam
A search for a narrow scalar resonance decaying into an opposite-sign muon pair produced in events with and without b-tagged jets is presented in this paper. The search uses 36.1 fb−1 of s=13 TeV proton-proton collision data recorded by the ATLAS experiment at the LHC. No significant excess of events above the expected Standard Model background is observed in the investigated mass range of 0.2 to
This study investigates patterns of seasonal variation in hours worked by women employed in home-based industrial production in Sweden in the early 20th century. Previous studies often describe workers in this type of production as the most flexible segment of industrial workers, and highly dependent on seasonal fluctuations in supply and demand. However, few have studied this empirically. This stThis study investigates patterns of seasonal variation in hours worked by women employed in home-based industrial production in Sweden in the early 20th century. Previous studies often describe workers in this type of production as the most flexible segment of industrial workers, and highly dependent on seasonal fluctuations in supply and demand. However, few have studied this empirically. This st
Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. The intratumor heterogeneity is reflected in sub-populations of cancer cells that appear to Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. The intratumor heterogeneity is reflected in sub-populations of cancer cells that appear to
OBJECTIVE: This study examined the prevalence and correlates of physical violence and rape among female sex workers (FSWs) in Ethiopia.DESIGN: A cross-sectional study using respondent-driven sampling technique.SETTING: Eleven major towns in Ethiopia.PARTICIPANTS: 4900 FSWs.MAIN OUTCOME MEASURES: The prevalence of experiences of physical beating and rape.RESULTS: Among FSWs, 17.5% reported physical
In this work, we study the formation and chemical evolution of the Galactic bulge with particular focus on the abundance pattern ([Mg/Fe] versus [Fe/H]), metallicity, and age distribution functions. We consider detailed chemical evolution models for the Galactic bulge and inner disc, with the aim of shedding light on the connection between these components and the origin of bulge stars. In particu
The application of the Chao-Raimondi emittance adapter to the SOLEIL storage ring is studied theoretically in terms of linear and nonlinear beam dynamics. This unique scheme recently proposed elsewhere using a pair of emittance adapters and a solenoid in between them allows a local conversion of an electron beam in a third generation light source to an ultralow emittance beam of the fourth generat
MicroRNAs (miRNA) play an important role in various biological process by regulating gene expression. Their abnormal expression may lead to cancer. Therefore, analysis of such data may discover potential biological insight for cancer diagnosis. In this regard, recently many feature selection methods have been developed to identify such miRNAs. These methods have their own merits and demerits as th
The grand challenges of contemporary fundamental physics-dark matter, dark energy, vacuum energy, inflation and early universe cosmology, singularities and the hierarchy problem-all involve gravity as a key component. And of all gravitational phenomena, black holes stand out in their elegant simplicity, while harbouring some of the most remarkable predictions of General Relativity: event horizons,
Nanoparticle generation by aerosol methods, particularly spark ablation, has high potential for creating new material combinations with tailored magnetic properties. By combining elements into complex alloyed nanoparticles and controlling their size and structure, different magnetic properties can be obtained. In combination with controlled deposition, to ensure nanoparticle separation, it is poss
