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Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women were eligible for analysis. Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive
When mattering is defined as being able to disseminate ideas on a global scale, not all universities and researchers matter equally. Along with many other factors, geographical location can be a source of inequality in the science system, which is characterized by a persistent core–semi-periphery–periphery structure. Collaboration between high-, middle-, and low-income countries, frequently enable
Diatoms, the prominent photosynthetic eucaryotes, have inhabited the world’s oceans for at least the past 120 Ma since their first appearance in the Lower Cretaceous. There are also records of older diatoms, from the Jurassic dating to ca. 172 Ma and ca. 165 Ma, however these are poorly documented. The predicted origin time of diatoms using evolutionary relationships (molecular phylogenetics) yiel
BACKGROUND: The long-term effects of adjuvant polychemotherapy regimens in oestrogen-receptor-poor (ER-poor) breast cancer, and the extent to which these effects are modified by age or tamoxifen use, can be assessed by an updated meta-analysis of individual patient data from randomised trials.METHODS: Collaborative meta-analyses of individual patient data for about 6000 women with ER-poor breast c
Stable isotope analysis (N and C) of fossil cereal grains is regularly explored as a means of obtaining insights to past crop growing conditions and agricultural practices. In this study, we assessed how several growth conditions can affect δ15N and δ13C values of modern cereal grain with the aim to help understand isotopic values from ancient cereal remains. We investigated the impact of fertiliz
Although capacity development has been a key aspect of global aid policy for decades, success is limited. Capacity development is defined as a process, based on a partnership, to develop capacity to achieve a goal. The purpose of this thesis is to increase our understanding of why capacity development does not work as intended, and to inform the discussion on addressing the challenges. Two researc
Background: The use of life stories in dementia care has been described as a way of seeing every person as an individual, looking beyond their dementia. Life stories have become synonymous with high-quality care, while in Sweden their mere existence in dementia care settings is taken to indicate quality in national comparisons. Such life stories are often standardised, generated by a family member
Currently, there appears to be an unhealthy disjunction between grand expectations and acknowledged reality in the face of urban transformations underway throughout the world. Drawing on the "right to the city" discourses, adopting a Lefebvrian approach to the production of space, and a critical regionalist approach to housing and the built environment, the article explores the conceptual analytic
While access and exposure to green spaces has been shown to be beneficial for the health of urban residents, interventions focused on augmenting such access may also catalyse gentrification processes, also known as green gentrification. Drawing from the fields of public health, urban planning and environmental justice, we argue that public health and epidemiology researchers should rely on a more
Study design: Psychometric study. Objectives: To i) describe the translation process and ii) explore the data completeness, targeting, reliability and aspects of validity of the Swedish version of Moorong Self-Efficacy Scale (s-MSES). Settings: Community rehabilitation program. Methods: Ninety-two program participants and 42 peer mentors with spinal cord injury (SCI) in Active Rehabilitation train
Research shows mental health is impacted by poor-quality physical and social-environmental conditions. Subsequently state-led redevelopment/regeneration schemes focus on improving the physical environment, to provide better social-environmental conditions, addressing spatial and socioeconomic inequities thus improving residents' health. However, recent research suggests that redevelopment/regenera
Decisions around prostate-specific antigen screening require a patient-centred approach, considering the benefits and risks of potential harm. Using shared decision-making (SDM) can improve men’s knowledge and reduce decisional conflict. SDM is supported by evidence, but can be difficult to implement in clinical settings. An inclusive definition of SDM was used in order to determine the prevalence
As global cities grapple with the increasing challenge of gentrification and displacement, research in public health and urban geography has presented growing evidence about the negative impacts of those unequal urban changes on the health of historically marginalized groups. Yet, to date comprehensive research about the variety of health impacts and their pathways beyond single case sites and thr
Urban insurgencies have spread across the globe like wildfire in recent years. The indignado plaza occupations in Spain are often cited as beacons of popular and widespread dissent. This article argues that urban insurgencies with the highest emancipatory potential in Spain today are found in the practices of the housing rights movement—the Plataforma de Afectados por la Hipoteca (PAH, or Platform
The neighborhood of Sant-Henri in Montréal’s Southwest borough has long been associated with poverty, marginality and squalor. But this is rapidly changing as both extraordinary, large-scale green infrastructures and small-scale, more ordinary forms of greening are expanding across the neighborhood, amidst private luxury housing development and rising rents. Both extraordinary and ordinary greenin
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA degradation. These small RNAs have recently been implicated in an evolutionarily conserved repertoire of biological processes. In this Review, we discuss the biogenesis and molecular functions of tdRs in mammals, including tdR-med
This chapter presents a methodological approach inspired by the various critical, continental approaches to deconstructing and recalibrating urban design in the context of development in the global south. After discussing the need to recalibrate urban design in terms of more complex understandings of informality; 'slum' as theory and as praxis; the notion of 'worlding'; and the existence of a mult
As assessing urban ecosystem services and disservices is of rapidly growing interest in a context of increasingly urbanized environments, greater scholarly attention needs to be placed on how different informants perceive these services and disservices. Previous research in urban geography and planning has already pointed at the challenges of building inclusive natural outdoor environments such as
In 2017, it was estimated that over 87,000 families—around 270,000 people—lived in squatted properties in Spain. Such figures, often used by the media to stigmatise residential occupations and generate moral panic, give an ill-defined yet powerful indication of the prevalence of squatting within and outside organised housing movements. From these came the question: How to elevate the “minor knowle
