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Cyclin E and the retinoblastoma protein (Rb) are both important regulators of the G1 phase in the cell cycle. Overexpression of cyclin E and lost expression of Rb has previously been observed in breast tumours at frequencies of 10-50% and 20-30%, respectively. We explored the prognostic role of cyclin E and Rb in breast cancer patients randomised for tamoxifen (TAM), CMF (cyclophosphamide, metotre

The purpose was to study the prognostic and predictive roles of DNA protein kinase catalytic subunit (DNA-PKcs), Ku70/80 and p53 for the effect of radiotherapy in breast cancer patients. Protein expressions of Ku70/80, DNA-PKcs and p53 were examined using immunohistochemistry in tumours from 224 breast cancer patients, who were randomised to receive post-operative radiotherapy or adjuvant chemothe

BACKGROUND: Early HIV diagnosis allows timely interventions to control HIV transmission. We have determined the proportion of recent infections among people living with HIV (PLHIV) enrolling to care in Ethiopia and identified factors associated with recent infection. METHODS: Participants (aged ≥ 15 years) newly enrolled in HIV care were recruited from urban clinics in central Ethiopia (2022-2024)

Background: Adjuvant therapy of breast cancer patients reduces the risk of recurrence and mortality, although, a substantial proportion of patients acquire resistance and relapse in the disease. Predictors of therapeutic response are therefore important to avoid both therapy resistance and the side effects of inefficient regimes. The p53 protein is a key determinant to induce either growth arrest

Sverige bör behandla den iranska regimen som en stående säkerhetsprioritet, och agera inom EU och Nato för att upprätthålla det politiska trycket mot Iran. Det skriver debattörer från Iran Prosperity Project.Sweden should treat the Iranian regime as a standing security priority, and act within the EU and NATO to maintain political pressure on Iran. That is what debaters from the Iran Prosperity Project write.

BACKGROUND AND OBJECTIVES: Subjective cognitive decline (SCD) is a well-recognized risk state for developing mild cognitive impairment (MCI) and dementia. Optimal risk stratification for early interventions and clinical trial selection remains challenging. This study evaluates progression risk across multimodal biomarker profiles in SCD.METHODS: We conducted a longitudinal observational study incl

Long RSH enzymes, Rel and RelA, are master regulators of bacterial (p)ppGpp alarmones levels. Bifunctional Rel transitions between a compact hydrolysis-competent (HD ON) state, a relaxed catalytically inactive (HD OFF/SYNTH OFF) state, and an elongated synthesis-competent (SYNTH ON) state, whereas RelA samples only the latter two. The distribution of these states is controlled by starved ribosomes

BACKGROUND: In patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) and who are treated with direct oral anticoagulants (DOACs), dual antithrombotic treatment without aspirin is recommended. Evidence comparing P2Y 12 inhibitor strategies in this setting is limited. AIMS: This study aimed to compare outcomes with ticagrelor versus clopidogrel as part of du

INTRODUCTION: We assessed the accuracy of the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) for clinical staging in Swedish primary care.METHODS: Participants from the Swedish BioFINDER Primary Care study were included. Discriminative performance of the A-IADL-Q was evaluated using receiver operating curves. Multinomial and linear regression models assessed association

Intense agricultural activity in recent years has resulted in a greater use of pesticides in order to improve productivity. However, these pesticides may contain some pollutant component in their composition. Once present in the environment and/or in excess, they can cause damage to the local flora and fauna. The aim of this study was to evaluate the interference of pesticides in the reproductive

This European Policy Analysis examines recent developments within the Council of Europe concerning a proposed political declaration by its Committee of Ministers on the European Court of Human Rights’ approach to migration-related issues. These developments follow an Open Letter in May 2025 and a subsequent Joint Statement by a group of member states expressing concerns about the Court’s case-law

Study region: Trelleborg is a mid-sized coastal municipality in southern Sweden that has experienced repeated pluvial flooding in recent decades. The city comprises areas served by both combined and separate sewer systems and is increasingly exposed to intense short-duration rainfall events. This study uses 17 years (2006–2023) of property-level flood reports, in situ rainfall observations from mu

p53 protein accumulation and gene mutation have been implicated in resistance to cytotoxic treatment. This study was performed to further assess the predictive value of p53 in breast cancer. Postmenopausal patients were randomized to adjuvant chemotherapy with cyclophosphamide, metothrexate, or 5-fluorouracil (CMF) vs. postoperative radiotherapy. The patients were also randomized to adjuvant tamox

Rebecca Yarros’s Fourth Wing (2023) is a romantasy novel with a complex dragon society where dragons’ personalities, tempers and looks vary and affect each other. It is a new work of fiction, the first book in her still unfinished Empyrean series, and thus not many have had the chance to explore and discuss it in a formal capacity. The previous discussion is mainly made up of book reviews, and the

Denna uppsats analyserar hur agentbaserad e-handel ska klassificeras inom ramen för EU:s mervärdesskattesystem, med fokus på leveranser av varor. Agentbaserad e-handel innebär att konsumenter använder AI-agenter för att söka efter, välja ut och i vissa fall genomföra köp av varor genom ett AIgränssnitt. Uppsatsen undersöker vem som utgör beskattningsbar person, hur leverantörens tjänst ska karaktäThis thesis examines the EU VAT classification of agentic commerce in relation to goods, with particular focus on the conditions under which deemed supplier treatment may arise. Agentic commerce refers to the use of AI agents to search for, select, and in some configurations complete purchases of goods on behalf of a user through an AI interface. The thesis asks who qualifies as a taxable person,