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Background: Fremanezumab (TEV-48125) is a fully humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) that has shown positive results in the prevention of episodic migraine and chronic migraine. Previous preclinical studies have revealed CGRP antagonistic effects on intracranial arteries (ICA). The aim of the study was to evaluate the in vitro antagonistic effects of frem
Events can be modeled through a geometric approach, representing event structures in terms of spaces and mappings between spaces. At least two spaces are needed to describe an event, an action space and a result space. In this article, we invoke general mathematical structures in order to develop this geometric perspective. We focus on three cognitive processes that are crucially involved in event
New diamagnetic nickel(II) complexes based on an unsymmetrical (1-(3-((ditert-butylphosphino)methyl)phenyl)-N,N-dimethyl-methanamine) (PCN) pincer ligand were synthesized and characterized by 1H, 31P{1H}, and 13C{1H} NMR spectroscopy. Their molecular structures were confirmed by X-ray diffraction. Oxidation to high-valent paramagnetic Ni(III) dihalide complexes was achieved through straightforward
Extremely metal-poor (EMP) stars are an integral piece in the puzzle that is the early universe, and although anomolous subclasses of EMP stars such as carbon-enhanced metal-poor (CEMP) stars are well studied, they make up less than half of all EMP stars with [Fe/H] ∼ -3.0. The amount of carbon depletion occurring on the red giant branch (carbon offset) is used to determine the evolutionary status
Background: Trichoderma fungi live in the soil rhizosphere and are beneficial for plant growth and pathogen resistance. Several species and strains are currently used worldwide in co-cultivation with crops as a biocontrol alternative to chemical pesticides even though little is known about the exact mechanisms of the beneficial interaction. We earlier found alamethicin, a peptide antibiotic secret
Soils harbour some of the most diverse microbiomes on Earth and are essential for both nutrient cycling and carbon storage. To understand soil functioning, it is necessary to model the global distribution patterns and functional gene repertoires of soil microorganisms, as well as the biotic and environmental associations between the diversity and structure of both bacterial and fungal soil communi
This article draws on a decade of research in strategic communication and especially on the contributions in this special issue to propose a new and more comprehensive definition of strategic communication. We argue that strategic communication encompasses all communication that is substantial for the survival and sustained success of an entity. Specifically, strategic communication is the purpose
The article explores how strategic communication successfully established itself as an academic discipline despite (or perhaps because of) being centered on an elusive concept. Drawing on ideas about the evolution of academic disciplines proposed by Alexander M. Shneider, we argue that strategic communication is currently caught in a cycle of constant reinvention obscured by a discourse of emergen
This study explores future directions in strategic communication scholarship by examining the emergence of strategic communication through the lens of interdisciplinary science. The disciplinary status of strategic communication is described through a content analysis of manuscripts published in the International Journal of Strategic Communication since its inaugural issue in 2007 (N = 207). Resul
Background: Alzheimer’s disease is characterized by aggregated β-amyloid and tau proteins, but the clinical presentations and patterns of brain atrophy vary substantially. A part of this heterogeneity may be linked to the risk allele APOE ε4. The spread of tau pathology is related to atrophy and cognitive decline, but little data exist on the effects of APOE ε4 on tau. The objective of this prelim
We propose that the ground term transition, 2p5P3/22-P1/22, for ions in the F-like isoelectronic sequence could be used to accurately test current methods to compute Breit and quantum-electrodynamic (QED) effects. These systems are of interest since correlation is small due to what we will label Layzer quenching. Using the multiconfiguration Dirac-Hartee-Fock method, we investigate how correlation
The energetic properties of electron transport in mesoscopic and nanoscale conductors are of considerable interest at present. Here, we theoretically investigate the possibility of probing charge- and heat-current fluctuations as well as their mixed correlations via the temperature and electrochemical potential fluctuations of a probe coupled to the conductor. Our particular interest is devoted to
The neutron-unbound isotope Be13 has been studied in several experiments using different reactions, different projectile energies, and different experimental setups. There is, however, no real consensus in the interpretation of the data, in particular concerning the structure of the low-lying excited states. Gathering new experimental information, which may reveal the Be13 structure, is a challeng
The building permission process is to a large extent an analogue process where much information is handled in paper format or as pdf files. With the ongoing digitalisation in society, there is a potential to automate this process by integrating Building Information Models (BIM) of planned buildings and geospatial data to check if a building conforms to the building permission regulations. In this
The next generation of mobile networks will exploit frequencies above 5 GHz and will use a wide available bandwidth for high speed data communication. At the time of writing this thesis work is ongoing to launch into the market a communication system operating between 25 GHz and 30 GHz. Following news about 40 GHz spectrum acquisition by telecommunication companies, it will be the next in turn. At
The evidence concerning how posture influences blood pressure is not consistent. The aim of this cross-sectional study was to consider the clinical and epidemiological implications of blood pressure measured in seated versus supine position, and to investigate the impact of age, sex, body mass index (BMI), and diabetes on these differences.This study included 1298 individuals (mean age 58.6 ± 11.8
In this work, we consider expressions for the masses and decay constants of the pseudoscalar mesons in SU(3) chiral perturbation theory. These involve sunset diagrams and their derivatives evaluated at p2=mP2 (P=π, K, η). Recalling that there are three mass scales in this theory, mπ, mK and mη, there are instances when the finite part of the sunset diagrams do not admit an expression in terms of e
