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Purpose: The goal of this research was to evaluate a potential therapeutic agent for breast cancer based on galectin-3 that has been implicated in tumorigenicity and metastasis of breast cancer. The hypothesis was that therapy with NH2-terminally truncated form of galectin-3 (galectin-3C) will be efficacious for reduction in tumor growth and for inhibition of metastases. Experimental Design: Recom
Two different dowel-type joints of differing size were loaded in tension parallel to the grain. The strain distribution in the joint area was studied using a contact-free measurement system. The results were compared with those of numerical analysis. The measurement system was found to be a valuable complement to traditional measurement techniques and also to numerical analyses performed in parame
The adsorption of water and coadsorption with oxygen on Rh{111} under ultrahigh vacuum conditions was studied using synchrotron-based photoemission and photoabsorption spectroscopy. Water adsorbs intact on the clean surface at temperatures below 154 K. Irradiation with x-rays, however, induces fast dissociation and the formation of a mixed OH+H2O layer indicating that the partially dissociated lay
in search for a strawberry (Fragaria ananassa) with low allergen content, we determined the proteomic variation within and between different varieties. Proteomics data were generated by DIGE and proteins identified with MALDI-MS/MS. The amount of the strawberry allergen Fra a 1 varied between different strawberry varieties (CV = 39%). The variation was at the same level, or even slightly larger, d
Corylus avellana L. (hazel, Betulaceae) is a long-lived, widespread shrub in Europe, having its northern range margin in Fennoscandia and a postglacial history involving range-expansion from refugial areas in southern Europe. In this study, we tested for a relationship between marginality and low within-population genetic diversity by assessing patterns of variation at 14 putatively neutral allozy
The purpose of this study was to investigate the effect of atropine on peripheral vasodilation and the mechanisms involved. The isometric tension of rat mesenteric artery rings was recorded in vitro on a myograph. The results showed that atropine, at concentrations greater than 1 mu M, relaxed the noradrenalin (NA)-precontracted rat mesenteric artery in a concentration-dependent manner. Atropine-i
1 We investigated morphological responses of the submerged macrophyte Myriophyllum spicatum L. to water depth and wave exposure when grown in the same substrate at two sites in two eutrophic lakes. Periphyton production was 4-8 times higher at sheltered than at wave-exposed sites and its influence was further investigated in a glasshouse experiment. Morphological responses in both experiments were
The method of using morselized compacted cancellous allografts for hip arthroplasty revision shows results that seem to differ dramatically from other kinds of allografting. In structural cancellous allografts, bone ingrowth usually is limited to 2 to 3 mm, whereas morselized compacted grafts seem to be remodeled totally in several cases, as judged by radiography. In the current study, impacted ca
To provide better understanding of how a protein secondary structure affects protein-protein and protein-surface interactions, forces between amphiphilic alpha-helical proteins (human apolipoprotein AII) adsorbed on a hydrophilic surface (mica) were measured using an interferometric surface force apparatus (SFA). Forces between surfaces with adsorbed layers of this protein are mainly composed of e
OBJECTIVE: To study the prevalence of patients fulfilling the clinical consensus criteria for dementia with Lewy bodies (DLB) in a dementia population followed up with postmortem examination. To compare the clinical and neuropathological findings in the clinical Lewy body dementia (LBD) group with findings in a clinically defined group with Alzheimer's disease (AD). DESIGN: Medical records from 20
Thermal manikins have served research and development purposes for more than 60 years. They are widely used for analysing the thermal interface of the human body and its environment. Particular applications are found in the determination of thermal properties of clothing and in the evaluation of the local body-heat fluxes in complex environments such as in a vehicle cabin. Recent developments of s
In 14 pigs the infrarenal vena cava was replaced with a peritoneal tube graft or a collagen-coated double velour graft. With 111In-labelled platelets dynamic in vivo imaging of platelet aggregation over the graft was carried out using a scintillation camera. After removal, the grafts were examined by autoradiography for an evaluation of the platelet aggregation pattern. Measurements of activity in
SpeB is a cysteine proteinase and virulence determinant secreted by the important human pathogen Streptococcus pyogenes. Recent investigations have suggested a role for SpeB in streptococcal entry into human cells. However, conflicting data concerning the contribution of SpeB to internalization have been presented. Protein F1 is a cell-wall-attached fibronectin (Fn)-binding protein that is present
This article examines some of the factors that may have affected the tendency for social workers to refer adolescents to a randomised controlled study of multisystemic therapy (MST). If we are to improve integration between researchers and the clinical setting in the future, it is important to consider those factors that affect implementation of research projects and evidence-based treatment metho
To assess the value of ECG-gating for the diagnosis of myocardial infarction using myocardial perfusion scintigraphy (MPS) and an artificial neural network. A total of 422 patients referred for MPS were studied using a one day Tc-99m-tetrofosmin protocol. Adenosine stress combined with submaximal dynamic exercise was used. The images were interpreted by one of three experienced clinicians and thes
Aim Africa is identified by the Inter-governmental Panel on Climate Change (IPCC) as the least studied continent in terms of ecosystem dynamics and climate variability. The aim of this study was (1) to adapt the Lund-Postdam-Jena-GUESS (LPJ-GUESS) ecological modelling framework to Africa by providing new parameter values for tropical plant functional types (PFT), and (2) to assess the sensitivity
Risk preferences related to accidents or other situations involving the possibility of multiple fatalities were studied in 87 persons in Sweden belonging to two separate groups with professional or educational knowledge of risk- and crisis-management issues. Use was made of a tradeoff method, the results obtained consisting of von Neuman-Morgenstern utility functions over the range of 0-1000 fatal
Hieracium incurrens Saelan ex Norrl., originally described from Finland, has been reported from Sweden several times and independently by different authors. Still, however, its presence in Sweden has remained dubious and it has become obvious that the different reports are referable to different taxa and the name has thus been, at least partially, misapplied. In the present study, all Swedish mate
