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Our aim was to analyze retinal structure in young patients with Best disease with reference to future gene therapy. This was a retrospective observational spectral domain optical coherence tomography study of four patients aged 10 years or less with Best disease. Findings ranged from subtle thickening at the level of the retinal pigment epithelium-photoreceptor interdigitation line, to subretinal
Reasons are facts, i.e., they are constituted by facts. This “reason quo fact” claim is much endorsed in recent literature. This paper addresses some issues that arise when we apply this idea to the distinction between agent-neutral and agent-relative normative reasons. I shall mainly consider two views of the nature of facts. Given a popular view, which conceives of facts as abstract entities, th
Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).
The deletion-contraction algorithm is perhaps the most popular method for computing a host of fundamental graph invariants such as the chromatic, flow, and reliability polynomials in graph theory, the Jones polynomial of an alternating link in knot theory, and the partition functions of the models of Ising, Potts, and Fortuin-Kasteleyn in statistical physics. Prior to this work, deletion-contracti
This paper presents a joint experimental and large eddy simulation (LES) study of lean premixed low swirl stabilized methane/air flames at different Reynolds numbers (Re similar to 20,000-100,000). The aims are to investigate the sensitivity of the structures and dynamics of low swirl flames to the inflow boundary conditions and to evaluate the capability of an LES flamelet model in predicting the
BACKGROUND: It is widely accepted that DNA double-strand breaks (DSBs) and their misrepair in stem cells are critical events in the multistage origination-of various leukemias and tumors, including gliomas. OBJECTIVES: We studied whether microwaves from mobile telephones of the Global System for Mobile Communication (GSM) and the Universal Global Telecommunications System (UMTS) induce DSBs or aff
Background The perception of surgery as expensive and complex might be a barrier to its widespread acceptance in global health efforts. We did a systematic review and analysis of cost-effectiveness studies that assess surgical interventions in low-income and middle-income countries to help quantify the potential value of surgery. Methods We searched Medline for all relevant articles published betw
This paper presents an existence and stability theory for gravity-capillary solitary waves on the surface of a body of water of infinite depth. Exploiting a classical variational principle, we prove the existence of a minimiser of the wave energy epsilon subject to the constraint I = root 2 mu, where I is the wave momentum and 0 < mu << 1. Since epsilon and I are both conserved quantities a standa
Density functional theory calculations and high-resolution core-level spectroscopy are used to explore the remarkable observation of decreased Ag 3d binding energy upon silver oxidation. The shift in Ag 3d binding energy is investigated at different degrees of oxidation and compared to results for Pd 3d, which exhibits a normal shift. Analysis of initial-state effects and valence electronic struct
The complete surgical removal of disease is a desirable outcome particularly in oncology. Unfortunately much disease is microscopic and difficult to detect causing a liability to recurrence and worsened overall prognosis with attendant costs in terms of morbidity and mortality. It is hoped that by advances in optical diagnostic technology we could better define our surgical margin and so increase
Formyl (HCO) has since long been recognized as a common intermediate species and a potential local indicator of the major heat release in hydrocarbon combustion. Consequently, the detection of HCO is desirable especially in turbulent flames of practical relevance. However, due to the low concentration and low fluorescence quantum yield, single-shot based detection of HCO with planar laser-induced
Objectives: To investigate patients' mobility and satisfaction with their lower-limb prosthetic or orthotic device and related service delivery in Sierra Leone; to compare groups of patients regarding type and level of assistive device, gender, area of residence, income; and to identify factors associated with satisfaction with the assistive device and service. Methods: A total of 139 patients ans
Abstract in Undetermined A number of reforms have been implemented in Swedish health care to support integrated care for frail older people and to reduce utilization of hospital care by this group. Outcomes and process indicators have been used in pay-for-performance (P4P) schemes by both national and local governments to support developments.
We evaluate the impact of cooperation with public research on firms' product and process innovations in France and Germany using Community Innovation Survey data from 2004 and 2008. We find that cooperating with public research increases product innovation, but has no effect on process innovation, which depends more on firms' openness. Our benchmark estimates, which are very similar in 2004 and 20
The geometric distribution leads to a Lévy process parameterized by the probability of success. The resulting negative binomial process (NBP) is a purely jump and non-decreasing process with general negative binomial marginal distributions. We review various stochastic mechanisms leading to this process, and study its distributional structure. These results enable us to establish strong convergenc
This article investigates the nominal vocabulary labeling features of the landscape in Makalero, a Papuan language of East Timor. Makalero landscape terms are shown to behave grammatically like place names rather than like common nouns, thus reflecting the ontological distinction between places and objects as discussed in linguistic semantics. It is argued that cultural parameters underlie the mor
This article develops two arguments. First, at a national level in Bulgaria, the human trafficking framework is inoperable for identifying abuses worthy of consideration. By comparing the Bulgarian criminal law definition of human trafficking with the international law definition, I argue that the national criminal law definition is overly inclusive. This state of the Bulgarian criminal law makes
As the earth is getting warmer, many animals and plants have shifted their timing of breeding towards earlier dates. However, there is substantial variation between populations in phenological shifts that typically goes unexplained. Identification of the different location and species characteristics that drive such variable responses to global warming is crucial if we are to make predictions for
