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Introduction: Perioperative dosing recommendations vary across Nordic haemophilia treatment centres (HTCs) for extended half-life (EHL) factor concentrates in haemophilia A/B (HA/HB) patients. Aim: To summarise Nordic real-world surgical experiences with EHL recombinant factor VIII/IX Fc (rFVIIIFc/rFIXFc) fusion proteins using retrospective data from clinical records at four HTCs in Finland, Swede

This chapter reviews the most important beginning with the long tradition of prescriptive tracts, offering observations and advice concerning the conduct of diplomacy. Authors from du Rosier to Nicolson were practitioners, who not only aimed at describing and explaining diplomacy but also had a clear prescriptive bent, offering recommendations as to the best conduct of diplomacy. War and military

I Sverige kommer ungefär 2-3 % av befolkningen någon gång att drabbas av paniksyndrom med eller utan agorafobi (PS/A), ett tillstånd som består av plötsliga, oväntade panikattacker som följs av ihållande rädsla för nya attacker och/eller betydande livsstilsförändringar. PS/A debuterar oftast i slutet av tonåren eller i tidig vuxenålder och ger om den förblir obehandlad ofta kroniska psykiska besväApproximately 2-3% of adults in Sweden will experience unexpected panic attacks that cause them to develop fears of future attacks and to alter their lives, defined as Panic Disorder with or without Agoraphobia (PD/A). The condition often onsets in late adolescence or early adulthood, with high levels of psychiatric comorbidity, social difficulties, diminished study and work ability, an elevated r

The recent COVID-19 pandemic highlighted the need of non-pharmaceutical interventions in the first stages of a pandemic. Among these, lockdown policies proved unavoidable yet extremely costly from an economic perspective. To better understand the tradeoffs between economic and epidemic costs of lockdown interventions, we here focus on a simple SIR epidemic model and study lockdowns as solutions to

In the present paper I will demonstrate the history of Raqqa’s cultural heritage, its floruit and its destruction, from its resettlement in the 19th century until the “Islamic State” period. I will also discuss the recent situation and the challenges to heritage associated with post-war construction in Raqqa. Raqqa was the summer capital of the caliph Harun Al Rashid and the centre of government f

The Fertile Desert studies a region of the Euphrates Valley between the Balikh and Khabour in Syria that remains little known. Partial reports, isolated interventions, and proposals for a hypothetical reconstruction of the relationship and processes of cultural expansion between Mesopotamia and the Jazira suggest that the Euphrates has always been a major traffic route. But suggestions on a map mu

Radiotherapy can induce an immunological response. One limiting factor is side effects on normal tissue. Using FLASH radiotherapy, side effects could possibly be reduced. The efficacy of FLASH in relation to conventional radiotherapy (CONV-RT) has not been extensively explored in fully immunocompetent animals. Fully immunocompetent Fischer 344 rats were inoculated with NS1 glioblastoma cells subcu

Patients with rheumatoid arthritis (RA) have an increased risk of infections; therefore, immunization against vaccine-preventable diseases is important. Methotrexate (MTX) impairs the antibody response to pneumococcal conjugate vaccine (PCV) in patients with arthritis, and the underlying mechanism is largely unknown. Here, we investigate the potential role of the innate immune system in the falter

Samtalsterapi – som inom socialt arbete utförs av exempelvis kuratorer och familje- rådgivare – syftar bland annat till att finna en tolkningsram för den hjälpsökandes svåra upplevelser. I detta arbete finns en utmaning: att å ena sidan peka ut problematiska tankar, känslor och beteenden och å andra sidan stärka den hjälpsökandes positiva självbild. I kapitlet ser vi hur personers olyckliga barndo

Aims To investigate self-reported cold sensitivity and functional disability after a repaired major nerve trunk injury in the upper extremity. Methods We identified 735 individuals with a major nerve trunk injury in the upper extremity, surgically treated with direct nerve repair or reconstructed with nerve autografts, in the Swedish national quality registry for hand surgery (HAKIR). Patient-repo

Patients with heart valve prosthesis (HVP) and Staphylococcus aureus bacteremia (SAB) are at risk for endocarditis. In this retrospective, population-based cohort study of 134 patients with SAB and HVP, 97 patients (72%) were diagnosed with possible endocarditis. Despite that most patients with possible endocarditis received short antibiotic treatment, only 3 patients suffered recurrent SAB.

Introduction: Cardiac resynchronization therapy (CRT) is an established treatment for heart failure in selected patients. However, current guideline indications do not accurately predict individual prognosis with CRT, and up to 30% are nonresponders. Previous studies have shown that QRS area reduction following CRT is associated with improved survival. This study evaluates the incremental value of

Aim: This randomised controlled trial evaluated changes in parental self-efficacy and children's weight, after a Child-Centred Health Dialogue about preventing obesity. Methods: We randomly assigned 37 Child Health Centres in Skåne county Sweden to provide usual care or the dialogue intervention. They included centres from high and low socioeconomic areas. The outcomes were changes in parental sel