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Polydopamine functionalized dendritic fibrous silica nanoparticles as a generic platform for nucleic acid-based biosensing

Accurate and rapid detection of nucleic acid sequences is of utmost importance in various fields, including disease monitoring, clinical treatment, gene analysis and drug discovery. In this study, we developed a "turn-on" fluorescence biosensor that enables simple and highly efficient detection of nucleic acid biomarkers. Our approach involves the utilization of 6-carboxyfluorescein modified singl

Detection of Pseudomonas aeruginosa infection using a sustainable and selective polydopamine-based molecularly imprinted electrochemical sensor

Pyocyanin, a redox-active secondary metabolite produced by Pseudomonas aeruginosa, serves as a crucial virulence factor. Detection and quantification of pyocyanin can aid early diagnosis of infection. A selective and sensitive molecularly imprinted electrochemical sensor was constructed by using a green polymerization technique to deposit an ultrathin polydopamine film on an electrode modified wit

Shape optimization of buckling-based deployable stiff structures

This study considers deployable structures and presents a novel optimization method that aims to improve the stiffness at the fully deployed state. The considered structures consist of curved beams that deploy through buckling when rotated. The optimization aims to maximize the structural tangent stiffness by modifying the shape of the beam elements. To accurately predict the deformation, Finite E

Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche

Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM

Topology optimization for designing periodic microstructures based on finite strain visco-plasticity

In the current work, we present a topology optimization framework for designing periodic microstructures with viscoplastic constitutive behavior under finite deformation. Materials with tailored macroscopic mechanical properties, i.e. maximum viscoplastic energy absorp- tion and prescribed Poisson's ratio, are designed by performing numerical tests of a single unit cell subjected to periodic bound