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Objective. To determine the concentrations of aggrecan fragments in synovial fluid from patients with knee joint injury, osteoarthritis (OA), or acute pyrophosphate arthritis (PPA; pseudogout), and to test their relative reactivity with the 846 epitope, a putative marker of cartilage aggrecan synthesis. Methods. Samples of knee joint fluid from 385 patients and 9 healthy-knee volunteers were obtai
Sustainability and the Political Economy of Welfare raises the issue of what is required to make welfare societies ecologically sustainable. Consisting of three parts, this book regards the current financial, economic and political crisis in welfare state institutions and addresses methodological, theoretical and wider conceptual issues in integrating sustainability. Furthermore, this text is conc
Rapid and powerful host defense mechanisms are essential in order to overcome harmful actions of pathogenic bacteria. Antimicrobial peptides (AMPs) and proteins are vital effector molecules of the fast-acting innate immune system and exist virtually in all living organisms. They exert a broad spectrum of natural antibiotic activity, but also play important immunomodulatory functions in the host. D
Rapport från ett seminarium sept. 2014 i Manama i Zimbabwe, om diakonens identitet i Lutherska kyrkan i Zimbabwe och i Sverige, två år efter den första vigningen (ordinationen) av diakoner i Evangelical Lutheran Church in Zombabwe.Report from a seminar i Manama in Zimbabwe September 2014: "The Identity of the Deacon in Zimbabwe and Sweden", two years after the first ordination of deacons in the Evangelical Lutheran Church in Zimbabwe (ELCZ).
Iran is a large country in the Middle East, which is an extremely arid region. Like its neighbors, severe droughts and population growth have intensified Iran’s water shortage problems in the past two decades. Furthermore, climate change has the potential to impose additional economic and social pressure on it and all Middle Eastern countries. Thus, how future climate change will interact with soc
Software engineering considers performance evaluation to be one of the key portions of software quality assurance. Unfortunately, there seems to be a lack of standard methodologies for performance evaluation even in the scope of experimental computer science. Inspired by the concept of “instantiation” in object-oriented programming, we distinguish the generic performance evaluation logic from the
The spot pricing scheme has been considered to be resource-efficient for providers and cost-effective for consumers in the Cloud market. Nevertheless, unlike the static and straightforward strategies of trading on-demand and reserved Cloud services, the market-driven mechanism for trading spot service would be complicated for both implementation and understanding. The largely invisible market acti
Det är just avsaknaden av ett gemensamt europeiskt asylsystem som vållat de problem vi såg under föregående år, skriver doktoranden Jerker Karlsson i en replik.
In this article, the author compares equity and credit investors' opinions on price formation in the equity market. More exactly, he inverts the CreditGrades model in order to back out credit-implied stock prices and stock return volatilities from credit default swap spreads for companies in the DJIA index. The credit-implied stock prices often deviate significantly from actual stock prices over t
Interest has grown in using the requirement of total joint replacement (TJR) as a "hard" outcome measure. Limitations exist, however, in the use of such an outcome, in particular the variability in the decision to perform surgery, length of surgical waiting lists, and sensitivity to change. This special interest group is exploring ways of retaining the clinical relevance of TJR but overcoming the
Disease modifying drugs for osteoarthritis (OA) that may halt or retard joint destruction and at the same time possibly improve symptoms are being developed and tested at various stages in clinical trials. This has, for at least two reasons, focused attention on the need for identification of patient groups at high risk for incident or progressive OA. First, well characterized such groups may be u
Osteoarthritis does not deserve the term "degenerative joint disease", the course of the disease is characterized by dynamic changes in both synthesis and degradation of cartilage and other joint tissues. At the end stage all tissues of the joint are involved, not only the cartilage. In the early phases of the disease, changes in cartilage metabolism can be detected through assay of biomarkers in
