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A series of trimethylsilyl-protected di-alkynes incorporating 3,4-ethylenedioxythiophene (EDOT) linker groups Me3Si–CC–R–CC–SiMe3 (R = ethylenedioxythiophene-3,4-diyl 1a, 2,2′-bis-3,4-ethylenedioxythiophene-5,5′-diyl 2a, 2,2′,5′,2′′-ter-3,4-ethylenedioxythiophene-5,5′′-diyl 3a) and the corresponding terminal di-alkynes, H–CC–R–CC–H 1b–2b has been synthesized and characterized and the single crysta

This report summarises the most important lessons learned from the research project From waste management to waste prevention. In the research project, researchers from Lund University and the University of Gothenburg, but also Umeå University and the Royal Institute of Technology, have studied waste prevention.The aim of the project has been to identify and clarify the difficulties in realising t

This paper investigates the accuracy of using the Woxén equivalent chip thickness to represent feed, depth of cut, nose radius and major cutting angle in tool life modeling of machining low alloy steel in longitudinal turning. Hägglund’s way of calculating the equivalent chip thickness has been used and compared to the Woxén equation. The equivalent chip thickness was held constant as the tool lif

The paper addresses the inverse heat transfer problem, in which the dependence of the flux on time is determined on the basis of the measured temperatures in remote points of the tool body. The nonlinear heat equation is considered since the properties of the tool material are temperature-dependent. The machining time interval is divided into subintervals within which the change in the tool materi

Superhard cBN-based materials with Cr3C2, Cr2N and CrB2 binders were sintered in a high-pressure high-temperature (HPHT) toroidal apparatus under a pressure of 7.7 GPa and in the temperature range of 1600-2450°С. Initial mixtures of three compositions were chosen with 60 vol.% of cBN, 35 vol.% of binder phase and 5 vol.% of Al. Phase composition and microstructure of sintered samples were investig

4H-4a,9-Methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) (CAS # 211299-54-6) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7

The purpose of this study was to explore and compare different countries in what motivated research participants’ decisions whether to share their de-identified data. We investigated European DIRECT (Diabetes Research on Patient Stratification) research project participants’ desire for control over sharing different types of their de-identified data, and with who data could be shared in the future

Magnetoliposomes (MLs) were synthesized and tested for longitudinal monitoring of transplanted pancreatic islets using magnetic resonance imaging (MRI) in rat models. The rat insulinoma cell line INS-1E and isolated pancreatic islets from outbred and inbred rats were used to optimize labeling conditions in vitro. Strong MRI contrast was generated by islets exposed to 50 µg Fe/ml for 24 hours witho

Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 mo

BACKGROUND: Achieving weight loss is the cornerstone of the treatment of the metabolic consequences of obesity, in particular of glucose intolerance.OBJECTIVE: To determine whether improvement in glucose control depends on dietary macronutrient composition of the diet at identical weight loss.MATERIALS AND METHODS: Twenty-two weeks old diet-induced obese C57BL/6 mice lost weight through caloric re

AIMS/HYPOTHESIS: Hypoxia in the initial days after islet transplantation leads to considerable loss of islet mass and contributes to disappointing outcomes in the clinical setting. The aim of the present study was to investigate whether co-transplantation of human non-endothelial bone marrow-derived multipotent adult progenitor cells (MAPCs), which are non-immunogenic and can secrete angiogenic gr

We estimated the CH4 budget in Finland for 2004–2014 using the CTE-CH4 data assimilation system with an extended atmospheric CH4 observation network of seven sites from Finland to surrounding regions (Hyytiälä, Kjølnes, Kumpula, Pallas, Puijo, Sodankylä, and Utö). The estimated average annual total emission for Finland is 0.6 ± 0.5 Tg CH4 yr−1. Sensitivity experiments show that the posterior biosp

Lymphodepletion strategies are used in the setting of transplantation (including bone marrow, hematopoietic cell, and solid organ) to create space or to prevent allograft rejection and graft versus host disease. Following lymphodepletion, there is an excess of IL-7 available, and T cells that escape depletion respond to this cytokine undergoing accelerated proliferation. Moreover, this environment

The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is able to promote the generation of tolerogenic mature dendritic cells (mDCs) with an impaired ability to activate autoreactive T cells. These cells could represent a reliable tool for the promotion or restoration of Ag-specific tolerance through vaccination strategies, for example in type 1 diabetes patients. Howe