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Glucagon has long been defined by its glucogenic action and as a result α-cells have been characterised based largely on their interaction with glucose. Recent findings have challenged this preconception, bringing to the fore the significant role glucagon plays in amino acid breakdown and underlining the importance of amino acids in glucagon secretion. The challenge that remains is defining the me
Purpose: Guidelines recommend targeting mean arterial pressure (MAP) > 65 mmHg in patients after cardiac arrest (CA). Recent trials have studied the effects of targeting a higher MAP as compared to a lower MAP after CA. We performed a systematic review and individual patient data meta-analysis to investigate the effects of higher versus lower MAP targets on patient outcome. Method: We searched the
Cellular engulfment and uptake of macromolecular assemblies or nanoparticles via endocytosis can be associated to both healthy and disease-related biological processes as well as delivery of drug nanoparticles and potential nanotoxicity of pollutants. Depending on the physical and chemical properties of the system, the adsorbed particles may remain at the membrane surface, become wrapped by the me
Background: This cross-sectional study examined nationwide real-world associations between anti-inflammatory agent fills and suicide-related death rates in 20–24-year-olds across the 21 Swedish regions during 2006–2021. Methods: Nationwide Swedish registers were used to compare regional year-wise suicide-related mortality (SRM) and dispensations for anti-inflammatory agents (ATC-code: M01) in 20–2
Humaniora genomgick en djupgående förändring under efterkrigstiden, både som vetenskapsfält och kulturell företeelse. Av många kom humanistiska studier gradvis att uppfattas som en överflödig lyxföreteelse och klassisk bildning tappade mark i utbildningssystemet. Naturvetenskap, medicin och samhällsvetenskap hade avgjort lättare att motivera sin existens i folkhemmets Sverige. Men även om humaniorThis book highlights the diverse roles of the humanities in the history of the Swedish welfare society. This society has often been seen as dominated by an instrumental view of knowledge that rewarded the social sciences, natural sciences and technology, but the contributions in this book show the significant role that the humanities played in the Swedish welfare state. Various forms of humanistic
Enhanced recovery after surgery (ERAS) protocols comprise a multimodal approach to optimize patient outcome and recovery. ERAS guidelines recommend minimally invasive surgery (MIS) when possible. Key components in MIS include preoperative patient education and optimization; multimodal and narcotic-sparing analgesia; prophylactic measures regarding nausea, infection, and venous thrombosis; maintena
Importance: Nonsuicidal self-injury is prevalent in adolescence and associated with adverse clinical outcomes. Effective interventions that are brief, transportable, and scalable are lacking. Objective: To test the hypotheses that an internet-delivered emotion regulation individual therapy for adolescents delivered adjunctive to treatment as usual is superior to treatment as usual only in reducing
Dynamic Global Vegetation Models (DGVMs) provide a state-of-the-art process-based approach to study the complex interplay between vegetation and its physical environment. For example, they help to predict how terrestrial plants interact with climate, soils, disturbance and competition for resources. We argue that there is untapped potential for the use of DGVMs in ecological and ecophysiological r
Frost is damaging to plants when air temperature drops below their tolerance threshold. The set of mechanisms used by cold-tolerant plants to withstand freezing is called “hardening” and typically take place in autumn to protect against winter damage. The recent incorporation of a hardening scheme in the demographic vegetation model FATES opens up the possibility to investigate frost mortality to
Background: Fibroblast growth factor 21 (FGF21) has demonstrated efficacy for reducing liver fat and reversing non-alcoholic steatohepatitis in phase 2 clinical trials. It is also postulated to have anti-fibrotic effects and therefore may be amenable to repurposing for the prevention and treatment of chronic kidney disease (CKD). Methods: We leverage a missense genetic variant, rs739320 in the FGF
The article analyses policy contingencies and welfare conditionalityof school allowances in Swedish upper-secondaryeducation. In contrast to most countries' use of positiveincentives toward school attendance through added cashbenefitsfor targeted students, Sweden employs sanctionson a universal study allowance that in essence constitutesan age-extension of the universal child benefit. We analysere
Grain size affects the rates of aeolian sediment transport on beaches. Sediment in coastal environments typically consists of multiple grain-size fractions and exhibits spatiotemporal variations. Still, conceptual and numerical aeolian transport models are simplified and often only include a single fraction that is constant over the model domain. It is unclear to what extent this simplification is
The construction and general implications of a model with complete supersymmetric unification of the Standard Model matter content, interactions and families' replication into a single E8 gauge superfield in ten dimensions is presented. The gauge and extended Poincaré symmetries are broken through compactification of the T6/(Z3×Z3) orbifold with Wilson lines, which reduces the original symmetry an
Introduction: Individuals with type 2 diabetes (T2D) are at high risk of experiencing atherosclerotic cardiovascular disease (ASCVD), which is associated with morbidity, mortality and healthcare resource utilisation. Clinical guidelines recommend the use of glucose-lowering medications with cardiovascular benefits in individuals with T2D and cardiovascular disease, but there is evidence that this
