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The sFLASH project at DESY is an experiment to study direct seeding using a source based on the high-harmonic generation (HHG) process. In contrast to SASE, a seeded FEL exhibits greatly improved longitudinal coherence and higher shot-to-shot stability (both spectral and energetic). In addition, the output of the seeded FEL is intrinsically synchronized to the HHG drive laser, thus enabling pump-p
Since 2004 the free-electron laser FLASH at DESY has been operated in the Self-Amplified Stimulated Emission mode (SASE), delivering gigawatt pulses with wavelengths between 6.5 nm and 40 nm in the femtosecond domain. In 2009 DESY installed an additional radiofrequency module for controlling the phase space of the electron bunches that gives the possibility to generate bunches with high peak curre
Coherent harmonic generation can be obtained by means of frequency up-conversion of a high-power external laser focused into the first undulator of an optical klystron. The standard configuration is based on a single-pass device, where the seed laser is synchronized with an electron beam entering the first undulator of the optical klystron after being accelerated using a linear accelerator. As an
In the name of transparency and accountability, numbers and statistics have gained importance as indicators of quality, effectiveness and efficiency of welfare services such as social work. It has been argued that the requirements to formalise how and on what grounds decisions are made have undermined the professional autonomy and discretion of social workers. These requests have arguably also led
Thanks to an intensive technological effort in the framework of the EUFELE collaboration, the European FEL at ELETTRA was able to break the previous record for the shortest wavelength of an FEL oscillator. Novel solutions were adopted for multilayer mirrors to allow FEL operation in the wavelength region between 160 and 190 nm, which is one of the main targets of the project. The characteristics o
Organoids have extensive therapeutic potential and are increasingly opening up new avenues within regenerative medicine. However, their clinical application is greatly limited by the lack of effective GMP-compliant systems for organoid expansion in culture. Here, we envisage that the use of extracellular matrix (ECM) hydrogels derived from decellularized tissues (DT) can provide an environment cap
Swedish administrative law has not devoted much attention to the con-cepts of discretion or deference with respect to the administration. This is explained by the historically founded competence of administrative courts conducting a full review under the so-called administrative-judicial form of appeal. Here, the administrative court has the same decision-making competence as the deciding administ
Myxoinflammatory fibroblastic sarcoma (MIFS) has recurrent genetic features in the form of a translocation t(1;10)(p22-31;q24-25), BRAF gene fusions, and/or an amplicon in 3p11-12 including the VGLL3 gene. The breakpoints on chromosomes 1 and 10 in the t(1;10) cluster in or near the TGFBR3 and OGA genes, respectively. We here used a combination of deep sequencing of the genome (WGS), captured sequ
The dermatofibrosarcoma protuberans family of tumors (DPFT) comprises cutaneous soft tissue neoplasms associated with aberrant PDGFBR signaling, typically through a COL1A1-PDGFB fusion. The aim of the present study was to obtain a better understanding of the chromosomal origin of this fusion and to assess the spectrum of secondary mutations at the chromosome and nucleotide levels. We thus investig
Collective decision-making is predicted to be more egalitarian in conditions where the costs of group fission are higher. Here, we ask whether Trinidadian guppies (Poecilia reticulata) living in high or low predation environments, and thereby facing differential group fission costs, make collective decisions in line with this prediction. Using a classic decision-making scenario, we found that fish
We present a model for generating spacetime coordinates in the Monte Carlo event generator Herwig 7, and perform colour reconnection by minimizing a boost-invariant distance measure of the system. We compare the model to a series of soft physics observables. We find reasonable agreement with the data, suggesting that pp-collider colour reconnection may be able to be applied in larger systems.
The transcription factor TCF7L2 remains the most important diabetes gene identified to date and genetic risk carriers exhibit lower insulin secretion. We show that Tcf7l2 regulates the auxiliary subunit of voltage-gated Ca2+ channels, Cacna2d1 gene/α2δ-1 protein levels. Furthermore, suppression of α2δ-1 decreased voltage-gated Ca2+ currents and high glucose/depolarization-evoked Ca2+ signaling whi
Background: Physical and biological properties of dust particles might affect the availability and distribution of chemicals associated to indoor dust; however it has not been adequately examined. In this study, household dust from Shanghai was fractionated into five particle sizes and size distribution, morphology, surface area, organic matter, microorganisms, elemental composition, metals and or
Many nocturnal animals, including invertebrates such as scorpions and a variety of vertebrate species, including toadlets, flying squirrels, owls, and nightjars, emit bright fluorescence under ultraviolet light. However, the ecological significance of this unique coloration so attached to nocturnality remains obscure. Here, we used an intensively studied population of migratory red-necked nightjar
Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject
