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Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly i
Background: The use of insulin pumps (continuous subcutaneous insulin infusion [CSII]) in individuals living with type 1 diabetes (T1D) improves disease control. However, adverse skin reactions may hamper compliance. We aimed to assess the relationship of insulin pumps, particularly that of infusion set therapy, used in children and adults with T1D and dermatitis including allergic contact dermati
This paper presents a search for top-squark pair production in final states with a top quark, a charm quark and missing transverse momentum. The data were collected with the ATLAS detector during LHC Run 2 and correspond to an integrated luminosity of 139 fb−1 of proton-proton collisions at a centre-of-mass energy of s = 13 TeV. The analysis is motivated by an extended Minimal Supersymmetric Stand
This study explores the coating of photocatalytic nanoparticles with antimicrobial peptides (AMPs) for boosted antimicrobial effects, and how such effects depend on AMP properties. For this, TiO2 nanoparticles are coated with the AMP KYE21 or its hydrophobically enhanced variant WWWKYE21. Mirroring effects of free peptides, coated nanoparticles displayed higher binding and UV-induced degradation f
This chapter identifies factors impacting artists’ and cultural workers’ mental health. Structural conditions constitute power imbalances, such as inclusion mechanisms that influence privilege and possibilities to exhibit/publish artwork. Structural conditions also have an impact on the distribution of financial resources and the forming of new collective and inclusive networks, creating alternati
Background: Biliary tract cancers comprise a heterogeneous collection of malignancies usually described as cholangiocarcinoma of the intra- or extrahepatic bile duct, including perihilar cholangiocarcinoma and gallbladder cancer. Methods: A review of pertinent parts of the ESSO core curriculum for the UEMS diploma targets (Fellowships exam, EBSQ), based on updated and available guidelines for diag
CF-related diabetes (CFRD) is a prevalent comorbidity in people with Cystic Fibrosis (CF), significantly impacting morbidity and mortality rates. This review article critically evaluates the current understanding of CFRD molecular mechanisms, including the role of CFTR protein, oxidative stress, unfolded protein response (UPR) and intracellular communication. CFRD manifests from a complex interpla
We conducted measurements of K-+He3→πYN+N′ reactions using a 1GeV/cK - beam, with the objective of understanding the broad decay width of K̄NN (approximately twice as broad as that of Λ(1405) considered to be the K̄N quasibound state). We successfully reproduced distributions of the πYN invariant mass and momentum transfer for πYN using model-fitting functions for K̄NN formation and quasifree K̄ a
Importance: There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock. Objective: To determine whether prolonged β-lactam antibiotic infusions are associated with a reduced risk of death in critically ill adults with sepsis or septic shock compared with intermittent infusions. Data Sourc
The paper recommends a values-driven regeneration of research ethics for ethnography. In contrast to the current regulatory version of research ethics we propose a more subtle, field-oriented and traditional version, grounded in ethnographic experience. The paper is in three parts. The first part highlights the tacit assumptions of current systems of ethical approval for social research and their
Background: Stroke is a leading cause of acquired disability in adults worldwide, and the burden of stroke is projected to increase. Current long-term stroke outcome data including functional status, activity, and participation limitations as well as information on health-related quality of life (HRQoL) are vital for future rehabilitation and resource planning of stroke survivors. Methods: First-e
In this paper, we describe the extraction of all the location entries from a prominent Swedish encyclopedia from the early 20th century, the Nordisk Familjebok 'Nordic Family Book.' We focused on the second edition called Uggleupplagan, which comprises 38 volumes and over 182,000 articles. This makes it one of the most extensive Swedish encyclopedias. Using a classifier, we first determined the ca
Background: The COVID-19 pandemic has necessitated changes in European healthcare systems, with a significant proportion of COVID-19 cases being managed on an outpatient basis in primary healthcare (PHC). To alleviate the burden on healthcare facilities, many European countries developed contact-tracing apps and symptom checkers to identify potential cases. As the pandemic evolved, the European Un
Little is known about risk factors for central nervous system (CNS) relapse in mature T-cell and natural killer cell neoplasms (MTNKNs). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at the highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relaps
In health, the human heart is able to match ATP supply and demand perfectly. It requires 6 kg of ATP per day to satisfy demands of external work (mechanical force generation) and internal work (ion movements and basal metabolism). The heart is able to link supply with demand via direct responses to ADP and AMP concentrations but calcium concentrations within myocytes play a key role, signalling bo
Background: Acne vulgaris is a multifactorial disease of the pilosebaceous unit of human skin. Previous studies have identified an acne-associated dysbiosis of the skin microbiome. Objectives: This dysbiosis was mainly determined for Cutibacterium acnes. However, detailed analyses combining qualitative and quantitative aspects are scarce, also regarding the possible contribution of other skin bact
Both trio and population designs are popular study designs for identifying risk genetic variants in genome-wide association studies (GWASs). The trio design, as a family-based design, is robust to confounding due to population structure, whereas the population design is often more powerful due to larger sample sizes. Here, we propose KnockoffHybrid, a knockoff-based statistical method for hybrid a
We investigate sequential two-stage admission systems with public and private schools. A sequential notion of truthfulness, called straightforwardness, is introduced. Contrary to one-stage systems, sequentiality leads to a trade-off between the existence of a straightforward equilibrium and non-wastefulness. We identify the unique set of rules for two-stage systems that guarantees the existence of
Objective: A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown. We aim to determine whether individuals with new-onset unprovoked seizures after middle age should undergo vascular risk assessment. The long follow-up needed to assess s
