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Functional magnetic resonance imaging (fMRI) is a widely used tool for studying brain function in vivo. The technique is based on acquiring brain images sensitive to the physiological response following neural activation, and hence, allows brain activity to be examined and documented. In this thesis, methods for fMRI mapping of the primary somatosensory cortex (S1) are optimised and subsequent

Objectives: This paper describes the dietary intake of total fat, saturated (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) and cholesterol of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) in 27 centres across 10 countries. Methods: Between 1995 and 2000, a stratified random sample of 36 034 participants (age range 35-74 years) complet

In this study, the spatial representativeness of eddy covariance (EC) methane (CH4) measurements was examined by comparing parallel CH4 fluxes from three short (6 m) towers separated by a few kilometres and from two higher levels (20 m and 60 m) at one location. The measurement campaign was held on an intensively managed grassland on peat soil in the Netherlands. The land use and land cover types

The 2(1)(+) states of Sn-114,Sn-116 were excited in two consecutive experiments by means of Coulomb excitation in inverse kinematics on a Ni-58 target. A precise determination of the reduced transition probability B(E2; 0(g.s.)(+) -> 2(1)(+)) of Sn-114 relative to the well-known 2(1)(+) excitation strength in Sn-116 was achieved by comparing the relative projectile to target 2(1)(+) -> 0(g.s.)(+)

Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and beta-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interact

Despite anti-dsDNA antibodies constitute a wide range of specificities, they are considered as the hallmark for systemic lupus erythematosus (SLE).

The REVEALS model was developed to reconstruct quantitatively regional vegetation abundance (in a 10(4)-10(5) km(2) area) from pollen assemblages in large lakes (>= 100-500 ha). This model corrects for biases in pollen percentages caused by inter-taxonomic differences in pollen productivity and dispersal. This paper presents the first case study to validate REVEALS, using empirical data from south

Measurements of fiducial and differential cross sections of Higgs boson production in the H -> ZZ* -> 4l decay channel are presented. The cross sections are determined within a fiducial phase space and corrected for detection efficiency and resolution effects. They are based on 20.3 fb(-1) of pp collision data, produced at root s= 8 TeV centre-of-mass energy at the LHC and recorded by the ATLAS de

Abstract is not available

We demonstrate the formation of a macroscopically oriented inverse bicontinuous cubic (QII) lipid phase from a sponge (L3) phase by controlled hydration during shear flow. The L3 phase was the monoolein/butanediol/water system; the addition of water reduces the butanediol concentration, inducing the formation of a diamond (QIID) cubic phase, which is oriented by the shear flow. The phenomenon was

Many fish species are able to produce sounds, which are often associated with courtship. In an earlier study, we showed for the Lake Victoria cichlid Pundamilia nyererei that females prefer to associate with a male with sound over a male without sound. As a follow-up to this earlier finding, we here investigated whether playback of conspecific sounds is sufficient to attract females in the absence

Context: Test driven development (TDD) has been extensively researched and compared to traditional approaches (test last development, TLD). Existing literature reviews show varying results for TDD. Objective: This study investigates how the conclusions of existing literature reviews change when taking two study quality dimension into account, namely rigor and relevance. Method: In this study a sys

To be able to robustly propagate P. falciparum at optimal conditions in vitro is of fundamental importance for genotypic and phenotypic studies of both established and fresh clinical isolates. Cryo-preserved P. falciparum isolates from Ugandan children with severe or uncomplicated malaria were investigated for parasite phenotypes under different in vitro growth conditions or studied directly from

Xenon atoms are double-ionized by sequential two-photon absorption by ultrashort extreme ultraviolet free-electron laser pulses with a photon energy of 23.0 and 24.3 eV, produced by the SPring-8 Compact SASE Source test accelerator. The angular distributions of photoelectrons generated by two-photon double ionization are obtained using velocity map imaging. The results are reproduced reasonably we

Atherosclerosis is a chronic inflammatory disease and the leading cause of myocardial infarction and stroke. Accumulation, aggregation and subsequent oxidation of LDL in the arterial wall are considered as key events in the development of atherosclerosis. The oxidation of LDL generates reactive aldehydes, including malondialdehyde (MDA) that modifies ApoB in LDL. Immune responses against MDA-modif