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Iridium ditelluride (IrTe2) as a two-dimensional (2D) transition metal dichalcogenide (TMDC) has attracted significant attention as a promising catalyst for oxygen evolution reactions (OERs). Although its electrochemical performance has been explored, detailed surface–state analyses are essential to fully elucidate the underlying catalytic mechanisms. Here, we fabricated surface-modulated IrTe2 th
Background: Whole Transcriptome Sequencing (WTS) is a comprehensive alternative to targeted panels for detecting gene fusions and splice variants. To integrate WTS into clinical diagnostics, we compared its performance against established fusion assays (Archer FusionPlex and TSO500 RNA). Methods: WTS was evaluated in an initial cohort of 64 FFPE tumor samples, and quality control (QC) thresholds w
Bifunctional DNA glycosylases employ an active site lysine or the N-terminus to form a Schiff base with an abasic (AP) site base excision repair intermediate. For 8-oxoguanine DNA glycosylase 1 (OGG1), cleaving this reversible structure is the rate-determining step in the initiation of 8-oxoguanine (8-oxoG) repair in DNA. Evolution has led OGG1 to use a product-assisted catalysis approach, where t
Primary graft dysfunction (PGD), defined as ventricular dysfunction occurring within 24 hours after heart transplantation (HTx) in the absence of identifiable secondary causes, remains a major contributor to early post-transplant mortality. Over the past decade, there has been a growing understanding of the burden of PGD, the clinical relevance of PGD classification and severity grading, and effor
Surface strain rates around the southeastern dome of Hans Tausen Iskappe in Peary Land, North Greenland (82.5° N, 27.5° W), are determined from global positioning system surveys of a strain net. Average longitudinal surface strain rate increases towards the dome, from (1.4 ± 0.2) × 10−4 a−1 at 5–10 ice thicknesses from the divide to (2.4 ± 1.0) × 10−4 a−1 within 1 ice thickness from the divide. An
A snowmobile towed impulse radar measurement was used to produce detailed maps of ice-thickness in two areas, one on a local dome (the Hans Tausen ice cap), and one on an outlet glacier north thereof. A constant spatial sampling was achieved by using a device attached to the snowmobile's odometer. The bedrock reflection was automatically detected in the majority of the data, by using digital signa
The expansive carbon reservoirs of the boreal region are becoming some of the most rapidly growing sources of greenhouse gasses under a positive feedback between intensifying fire activity and climate change. However, current regional-scale methods lack the spatial precision needed to improve understanding of the drivers of these fluxes to inform strategies aimed at maximizing landscape carbon sto
This introductory paper outlines the conceptual foundations and research agenda for our special issue Contextual Complexities of Violence on Digital Platforms. We argue that violence on digital platforms cannot be understood as a fixed or self-evident category, but must be situated within the sociotechnical, cultural and political environments that shape its production, circulation and recognition
Part of the online anthology of the artistic research project Costume Dramaturgies – The Dramaturgy of Things in Performance. The project explores the dramaturgy of things – as costume – in performance, where dramaturgy is understood as an assembly of human and nonhuman “things.”
Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gu
In Charlotte Østergaard’s artistic research practice, co-creation is not merely a matter of establishing horizontal forms of collaboration between people. It is an investigation of how people, textile materials and local atmospheres mutually influence and respond to each other. Here, Charlotte Østergaard provides an insight into her current research and practice.
Klebsiella pneumoniae is a major opportunistic pathogen, where the polysaccharide capsule is traditionally recognized as a critical virulence determinant. However, its role in surface interactions and intracellular adaptation remains incompletely understood. Here, we combined phenotypic assays with physicochemical analyses to dissect the contribution of the capsule. A wza knockout mutant displ
Recension av Anders Edling och Erik Wallrup, red., Emil Sjögren – en vägvisare, 2022. Möklinta: Gidlunds förlag. 252 s. ISBN 978-91-7844-502-8.
Somatostatin, produced by pancreatic islet δ cells, is a key intra-islet paracrine factor that regulates the secretion of the glucoregulatory hormones insulin and glucagon from β cells and α cells, respectively. Here, we show that glutamate and glucagon released by α cells cooperatively activate neighbouring δ cells through AMPA and glucagon receptors, thereby enabling spatiotemporal feedback cont
The physical placement of antennas is a design factor for Distributed Multiple-Input Multiple-Output (D-MIMO) systems, but finding the optimal layout is a computationally intensive, non-convex problem. Prior research often addresses this by directly optimizing the coordinates of each distributed panels using complex numerical techniques, such as convex relaxation or iterative algorithms. While via
