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Viral respiratory infections are increasingly implicated in allergic exacerbations. The mechanisms behind this are not known, but a virus-induced activation of eosinophils through TLRs could be involved. Herein, we investigated the expression and function of TLR7 and TLR9 in purified eosinophils from peripheral blood and assessed their role in allergic airway inflammation. Eosinophils expressed TL
ABSTRACT: INTRODUCTION: Collagen-induced arthritis (CIA) in mice is a commonly used experimental model for rheumatoid arthritis (RA). We have previously identified a significant quantitative trait locus denoted Cia40 on chromosome 11 that affects CIA in older female mice. This locus colocalizes with another locus, denoted Pregq2, known to affect reproductive success. The present study was performe
Advice on how to manage medications while traveling is provided. Considerations include carrying a letter from the treating physician or clinic, carrying adequate medication for a trip extension and keeping it in carry-on luggage, and utilizing governmental agency-issued certificates to allow carrying certain medications while traveling.
Gene therapy represents a promising approach for the treatment of monogenic and multifactorial neurological disorders. It can be used to replace a missing gene and mutated gene or downregulate a causal gene. Despite the versatility of gene therapy, one of the main limitations lies in the irreversibility of the process: once delivered to target cells, the gene of interest is constitutively expresse
The human placenta is a difficult tissue to work with using proteomic technology since it contains large amounts of lipids and glycogen. Both lipids and glycogen are known to interfere with the first step in the two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), the isoelectric focusing. In order to gain the best possible protein separation on 2D-PAGE, an optimized sample preparation pr
Five hundred and sixty-one managers in Central and Eastern Europe were asked how much they relied on each of eight sources of quidance in handling eight relatively routine work events. A previous study indicated particularly strong reliance on one's own experience and training in the Czech Republic and Hungary. Managers from Poland and Slovakia relied more on superiors, while in Romania and Bulgar
Objective. To follow the development of a class of pupils' tobacco habits for seven years, and to study differences in tobacco use between girls and boys. Setting. Kronoberg County in southern Sweden. Subjects. All the approximately 2000 pupils were followed from approximately age 12 to approximately age 18. Design. Yearly cross-sectional surveys from 1994 to 2000. Each year, the pupils filled in
Mitochondrial uptake of calcium in excitotoxicity is associated with subsequent increase in reactive oxygen species (ROS) generation and delayed cellular calcium deregulation in ischemic and neurodegenerative insults. The mechanisms linking mitochondrial calcium uptake and ROS production remain unknown but activation of the mitochondrial permeability transition (mPT) may be one such mechanism. In
This work tackles the challenge of assessment of force distributions in granular media. Spatially resolved neutron and x-ray diffraction are used to measure internal strains of sand grains under load. These approaches are sensitive to the crystallographic strains of the sand grains (quartz crystals) such that each grain acts as a local 3D strain gauge and so, for elastic deformations, a force gaug
BACKGROUND: Wilms tumor (WT) is the most common renal neoplasm in children. Histologically, most WTs consist of three tissue elements: blastema, epithelium, and stroma. Some cases also show diffuse or focal anaplastic features. Previous studies have shown that a predominance of blastemal cells in post-chemotherapy WT specimens is associated with a poor clinical course. However, there is currently
As genetic factors can hardly explain the changes taking place during short time spans, environmental and lifestyle-related factors have been suggested as the causes of time-related deterioration of male reproductive function. However, considering the strong heterogeneity of male fecundity between and within populations, genetic variants might be important determinants of the individual susceptibi
Blood parasite prevalence in two related warbler species (Acrocephalus arundinaceus and A. scirpaceus) was studied at three Bulgarian sites that differed mainly in altitude and weather. The prevalence of Haemoproteus, the most common parasite genus, was significantly lower at the highest altitude site (730 in above sea level, asl). Such a pattern was not found in ectoparasite-transmitted Hepatozoo
To investigate the efficacy of lingonberries in prevention of atherosclerosis, using atherosclerosis-prone Apoe-/- mice and to clarify whether effects were associated with changes in the gut microbiota, gut metabolites and lipid metabolism.
This study investigated if copeptin is affected by high salt intake and whether any salt-induced changes in copeptin are related to the degree of salt sensitivity. The study was performed on 20 men and 19 women. In addition to meals containing 50 mmol NaCl daily, capsules containing 100 mmol NaCl and corresponding placebo capsules were administered during 4 weeks each, in random order. Measurement
Genome-wide association studies (GWAS) have long relied on proposed statistical significance thresholds to be able to differentiate true positives from false positives. Although the genome-wide significance P-value threshold of 5 × 10(-8) has become a standard for common-variant GWAS, it has not been updated to cope with the lower allele frequency spectrum used in many recent array-based GWAS stud
