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Objective: To explore the effects of baroreflex activation therapy (BAT) on hypertension in patients with treatment resistant or refractory hypertension. Methods: This investigator-initiated randomized, double-blind, 1:1 parallel-design clinical trial will include 100 patients with refractory hypertension from 6 tertiary referral hypertension centers in the Nordic countries. A Barostim Neo System

Background: A distal forearm fracture is a very common injury causing both suffering and substantial health care costs. The incidence of this fracture type seemed to increase worldwide until the middle 1980’s, but thereafter most reports have shown stable or decreasing rates. As few large studies have been presented lately we aimed to describe recent epidemiology and time trends of distal forearm

Fetma och typ 2 diabetes är stora folksjukdomar som ökar i rasande takt världen över. En gemensam nämnare för dessa sjukdomar är att de vävnader i kroppen som reglerar ämnesomsättningen, t.ex. fettvävnaden, förlorar känsligheten för hormonet insulin så att det inte längre fungerar normalt. Detta kallas insulinresistens och i min forskning undersöker jag hur kroppens fettvävnad fungerar för att förObesity, insulin resistance and type 2 diabetes (T2D) are metabolic diseases that increase rapidly in the modern society. The underlying mechanisms are complex and involve both environmental and genetic factors. Adipose tissue is an important organ for maintaining whole body energy homeostasis. In response to nutrient overload (as observed in obesity), adipocytes become hypertrophic and dysfunctio

IMPORTANCE: The value of microRNAs (miRNAs) as biomarkers has been investigated in various clinical contexts. Initial small-scale studies suggested that miRNAs might be useful indicators of outcome after cardiac arrest. OBJECTIVE: To address the prognostic value of circulating miRNAs in a large cohort of comatose patients with out-of-hospital cardiac arrest. DESIGN, SETTING, AND PARTICIPANTS: This

The stability of a multi-controller system is analyzed using Lyapunov theory. Stability is guaranteed by a switching strategy determined by a combination of separate Lyapunov functions for the different controllers. The behavior on sliding surfaces is analyzed using non-smooth analysis according to Filippov. Two examples illustrate the theory.

Targeted temperature management (TTM) of 32-34 °C has been the standard treatment for out-of-hospital cardiac arrest since clinical trials in 2002 showed benefits to survival and neurological outcome. Recently, this treatment has been challenged by another clinical trial showing no difference in outcome between TTM of 33 °C and 36 °C. This protocol describes the methodology for a meta-analysis det

OBJECTIVE: To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3).METHODS: All prerandomization and follow-up (24-48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by masked raters. We assessed whether HAS grew, p

Previous work in the areas of organizational trust repair and crisis communication has provided conflicting answers to the question of whether denial can be more effective than apology in repairing stakeholder trust in a company following an integrity-based violation. This article reportsthe results of an experiment designed to (i) test the effects of these two strategies on individuals’ trust in

The stable isotope of carbon, 13C, has been used in several studies for source characterization of carbonaceous aerosol since there are specific signatures for different sources. In rural areas, the influence of different sources is complex and the application of δ13C for source characterization of the total carbonaceous aerosol (TC) can therefore be difficult, especially the separation between bi

Denna avhandling har tre utgångspunkter. Den första är den europeiska sociala dialogen (ESD), vilken har kritiserats för att sakna kapacitet för att förbättra arbetsvillkor i EU. Den andra är det globala systemet för kollektivavtal och förhandlingar som har utvecklats genom ITFs kampanj mot bekvämlighetsflagg (ITF FOC), vilket anses ha kapacitet att förbättra villkor för sjömän på global nivå. DenThere are three starting points for this thesis. First, there is the system of ESD, which is criticised for lacking capacity to improve the working conditions within the EU. Secondly, there is the system developed through the global ITF FOC campaign, which is considered to have capacity to improve working conditions for seafarers at a global level. Thirdly, there is the theory on self-referential

INTRODUCTION: A multimodal approach to prognostication of outcome after cardiac arrest (CA) is recommended. Evidence for combinations of methods is low. In this post-hoc analysis we described findings on head computed tomography (CT) after CA. We also examined whether generalised oedema on CT alone or together with the biomarker Neuron-specific enolase (NSE) could predict poor outcome.METHODS: Pat

AIM: To examine the psychometric properties of a modified version of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), for a cardiac arrest population (IQCODE-CA).METHODS: The IQCODE-CA, a 26-item observer-reported questionnaire, was completed by informants, defined as relatives or close friends, of 268 out-of-hospital cardiac arrest (OHCA) survivors who participated in the

INTRODUCTION: It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans.METHODS: Cerebral blood flow and amyloid β ((18)F-Flutemetamol) positron emission tomography retention were assessed in eleven patients with unilateral occlusion of

From at least the Late Neolithic through the end of the Bronze Age and onwards, people continued to inhabit the settlement of Asine. For this reason, the site makes an interesting starting point for discussing long term change. This short paper presents new data on the animal bones from Bronze Age Asine. The data set is used for a zooarchaeological discussion of the site from a diachronic perspectFrom at least the Late Neolithic through the end of the Bronze Age and onwards, people continued to inhabit the settlement of Asine. For this reason, the site makes an interesting starting point for discussing long term change. This short paper presents new data on the animal bones from Bronze Age Asine. The data set is used for a zooarchaeological discussion of the site from a diachronic perspect

Recent studies find that defection from one's most preferred party to some other party is as common under proportional representation (PR) as it is in plurality systems. It is less elaborated how election-specific contextual factors affect strategic vote choice under PR. This study looks at the impact of two potentially important contextual factors: parties’ coalition signals about cooperation wit