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Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10 −8 with BW were used to construct (1) a 41-SNP instrumental variable (IV

Introduction: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD. Methods: In 13 of the 23 centers of the European Prospective Investigation into C

Algorithms for Massive MIMO uplink detection typically rely on a centralized approach, by which baseband data from all antennas modules are routed to a central node in order to be processed. In case of Massive MIMO, where hundreds or thousands of antennas are expected in the base-station, this architecture leads to a bottleneck, with critical limitations in terms of interconnection bandwidth requi

Vi beskriver ett experiment att på en kurs i matematik införa veckovisa webbbaserade och automaträttade färdighetsprov i syfte att på ett kostnadseffektivt sätt introducera moment av löpande formativ bedömning i undervisningen och därigenom få studenterna att ligga bättre i fas och att hålla en jämnare arbetsbelastning under hela läsperioden.

Analyzing 70 countries over the period 1973–2006, we empirically show that, in the aftermath of financial crises, income inequality exhibits no general pattern of change. This holds for both advanced and emerging economies. However, when we break down the analysis by crisis types, we find that, after stock market crises, inequality goes down in advanced countries, while there is no statistically s

This paper studies political career incentives in a nondemocratic historical setting to assess early political institutions. We construct a novel panel database of governors of Imperial Russia in 91 provinces between 1895 and 1914. Measuring an imperial governor’s performance by his ability of peacekeeping, we test whether the central authorities in the Russian Empire resorted to career incentives

Abstract Background: Advanced paediatric surgery is increasingly centralised in Sweden in order to improve treatment outcomes and reduce surgical risks. However, the overall need for surgery in the paediatric population has not been estimated, and the association between geographic access to surgical facilities and timely treatment for common surgical conditions in children is largely unknown.

The second phase of the Fifth International Ice Nucleation Workshop (FIN-02) involved the gathering of a large number of researchers at the Karlsruhe Institute of Technology's Aerosol Interactions and Dynamics of the Atmosphere (AIDA) facility to promote characterization and understanding of ice nucleation measurements made by a variety of methods used worldwide. Compared to the previous workshop

The art of deciding the victor in the ancient pentathlon.

This paper presents a millimeter-wave (mm-wave) phase-locked loop (PLL), with an output frequency centered at 54.65 GHz. It demonstrates a mode-switching architecture that considerably improves the lock time, by seamlessly switching between a low-noise mode and a fast-locking mode that is only used during settling. The improvement is used to counteract the increased lock-time caused by cycle-slipsThis paper presents a millimeter-wave (mm-wave) phase-locked loop (PLL), with an output frequency centered at 54.65 GHz. It demonstrates a mode-switching architecture that considerably improves the lock time, by seamlessly switching between a low-noise mode and a fast-locking mode that is only used during settling. The improvement is used to counteract the increased lock-time caused by cycle-slips

Two low-power mm-wave voltage controlled oscillators (VCOs) designed in a 28-nm fully-depleted silicon-on-insulator (FD-SOI) CMOS process are demonstrated, using a push-pull differential architecture. Measurement show that the first VCO has a 10.8% tuning rage centered at 30.3 GHz, and the second has a 8.9 % tuning range at 58.7 GHz. The 30 GHz VCO consumes 1.06 mW from a 1 V supply, and has a −11Two low-power mm-wave voltage controlled oscillators (VCOs) designed in a 28-nm fully-depleted silicon-on-insulator (FD-SOI) CMOS process are demonstrated, using a push-pull differential architecture. Measurement show that the first VCO has a 10.8% tuning rage centered at 30.3 GHz, and the second has a 8.9 % tuning range at 58.7 GHz. The 30 GHz VCO consumes 1.06 mW from a 1 V supply, and has a -11

A three stacked power amplifier implemented in 28nm fully depleted silicon-on- insulator complementary metal oxide semi-conductor technology (FDSOI CMOS) is presented. It has a differential architecture with on-chip input and output transformer baluns. The PA achieves a saturated output power level of 17.9dBm with a peak power added efficiency of 7% and an output referred gain compression point ofA three stacked power amplifier implemented in 28nm fully depleted silicon-on-insulator complementary metal oxide semi-conductor technology (FDSOI CMOS) is presented. It has a differential architecture with on-chip input and output transformer baluns. The PA achieves a saturated output power level of 17.9dBm with a peak power added efficiency of 7% and an output referred gain compression point of

In empirical research it is often of interest to include non-linear functions of the explanatory variables, such as squares or interactions, in the specification. A popular technique to estimate such models in the presence of common factors is the Common Correlated Effects (CCE) methodology. However, this approach assumes that the regressors are linear in the factors, which is not the case if vari

Methylating substances alter DNA by forming N3-methylthymidine (N3mT), a mutagenic base modification. To develop a sensitive analytical method for the detection of N3mT in DNA based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF), we synthesized the N3mT-3'-phosphate as a chemical standard. The limit of detection was 1.9 amol of N3mT, which corresponds to one molecu

A new sensitive analytical method using capillary electrophoresis with laser induced fluorescence (CE-LIF) was applied for the simultaneous detection of DNA methylation and hydroxymethylation levels in human cancers of different origin. DNA hydroxymethylation, measured as 5-hydroxymethylcytosine (5hmC) levels, was decreased in gliomas with mutation in the isocitrate dehydrogenase 1 (IDH1) gene whe

Purpose – The purpose of this paper is to further develop the conceptualization of music consumption in the digital age by examining how contemporary music listening is interweaved with other practices, how it shapes those practices and how it is in turn shaped by them.Design/methodology/approach – The paper draws on extensive, qualitative interviews with 15 Swedish music consumers. During the cou