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OBJECTIVE: To characterize the clinical phenotype, with an emphasis on electrophysiologic findings, in a family with autosomal dominant retinitis pigmentosa caused by mutation in the recently identified KLHL7 gene. METHODS: Eleven patients from a single family were selected from the Swedish retinitis pigmentosa register. Four patients had been examined 13 to 17 years earlier and underwent further
AIM: To estimate the incidence of collagenous colitis (CC) in southern Sweden during 2001-2010. METHODS: Cases were identified by searching for CC in the diagnostic registers at the Pathology Departments in the county of Skåne. The catchment area comprised the south-west part of the county (394 307 inhabitants in 2010) and is a mixed urban and rural type with limited migration. CC patients that h
BACKGROUND: Polysubstance use is common in substance users, and may complicate their clinical course. This study, in a criminal justice setting in Sweden, examines the association between the number of concurrently used substance types and psychiatric symptoms during 30 days before incarceration, while controlling for background variables such as family history (drug and alcohol problems, psychiat
This article comments on three post-Second-World-War road novels: Kerouac’s On the Road(1957), Robbins’s Even Cowgirls Get the Blues(1976), Atkinson’s Highways and Dance Halls(1995). Framing its perspective within the question of what is involved in creating a 20th-century ‘traveller identity’, it conceptualizes the road in terms of how it historically and generically emerged as a primarily male t
The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and C
Several lines of evidence show that classical or Pavlovian conditioning of blink responses depends on the cerebellum. Recordings from cerebellar Purkinje cells that control the eyelid and the conditioned blink show that during training with a conditioning protocol, a Purkinje cell develops a pause response to the conditional stimulus. This conditioned cellular response has many of the properties t
The genetic cause of late-onset focal and segmental dystonia remains unknown in most individuals. Recently, mutations in Thanatos-associated protein domain containing, apoptosis associated protein 1 (THAP1) have been described in DYT6 dystonia and associated with some cases of familial and sporadic late-onset dystonia in Caucasians. We are not aware of any previous descriptions of familial dystoni
A modified local error model is developed for numerical integration of ODEs with invariants. The basic idea is to use a commutativity relationship that holds for implicit state-space form methods. A new implicit state-space form predictor is developed from which error estimates can be obtained by predictor-corrector difference: This technique is demonstrated through the preliminary examples in thi
The article investigates the notion of transport biofuels, their possible advantages and disadvantages in comparison to traditional fossil fuels, and sustainability requirements that need be stated to their quality and production methods from a legal perspective. The research results indicate that the understanding of what makes the quality and production of transport biofuels sustainable is still
Structural equation modeling on questionnaire data showed that prejudice toward different target groups can be represented in terms of a general prejudice factor. Distinction of classical and modern prejudice only increased model fit marginally. In two separate samples (paper and pencil vs. Internet) several structural models of the relationship between key individual difference variables and prej
Objective: We examined the effect of GH substitution on adipose tissue derived hormones and cytokines and sought to identify predictors for changes in body composition during therapy. Long-standing adult-onset GH deficiency (AO-GHD) is associated with increased body fat mass (FM) which, through production of hormones and inflammatory cytokines from adipose tissue, may contribute to different manif
In spite of its immune privileged state, xenotransplantation within the CNS is associated with rapid graft destruction in immunocompetent hosts. Efforts to enhance graft survival have mostly focused on host immune response, whereas relatively little attention has been paid to donor tissue characteristics. In the present paper, we explore long-term survival of xenogeneic full-thickness neuroretinal
The absorption spectrum of alpha -pinene gas, a biogenic volatile organic compound, was directly measured with a pulsed mid-infrared laser. The maximum absorption wavelength was found to be similar to3.42 mum, and an absorption cross section of 4.8 x 10(-23) m(2) molec(-1) was obtained. A simple theoretical calculation with the measured spectral data showed that several hundreds of parts in 10(12)
In this letter, the TM020 mode of a rectangular patch antenna is modified by partially loading a mu-negative (MNG) or double-negative (DNG) metamaterial block. With proper constitutive parameters and filling ratio, the electric fields at two radiating edges of the patch can be out of phase, and a broadside radiation pattern is achieved. A novel dual-band rectangular patch antenna loaded with a pai
Our aim was to determine the risk of endometrial cancer associated with long-term use of combined hormone therapy (HT) and low-potency estrogens. In this prospective population-based cohort, 40,000 women aged 25-64 years, without prior cancer or hysterectomy, were included. The women answered 2 questionnaires at a 10-year interval regarding HT use and personal details. Women were followed up for a
