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BACKGROUND: Apolipoprotein M (ApoM) is associated with lower mortality in heart failure (HF) patients and protects against cardiac and kidney injury in mice.OBJECTIVES: The authors investigated dapagliflozin's cardiorenal effects by studying its association with ApoM in patients with HF with reduced ejection fraction.METHODS: We performed a secondary analysis of DEFINE-HF (Dapagliflozin Effects on

INTRODUCTION: Trust in healthcare is central to the delivery of care and unequally distributed between groups in society. Experiences of perceived discrimination have been associated with lack of such trust. Although the importance of trust in healthcare has been highlighted in recent years, studies in this area are relatively scarce.MATERIALS AND METHODS: We investigated the risk of low trust in

Background: Inhibitory deficits are common in psychopathology. Emotion-related impulsivity (ERI) and rumination are general risk factors for psychiatric distress that are similarly associated with dysfunctional inhibition—particularly in affective contexts. A number of cognitive remediation procedures have been developed to improve inhibitory control; however, most remediation programs focus on “c

Dopamine replacement therapy for Parkinson's disease can induce impulsive-compulsive behaviours (ICBs). Here we compare the D2/3 agonist ropinirole and L-DOPA, given alone or combined, with regard to their potential to induce ICBs in rats sustaining bilateral striatal injections of 6-hydroxydopamine. Daily treatment with ropinirole (2.5 mg/kg), L-DOPA (24.0 mg/kg), or their combination was given f

Introduction: Acinetobacter baumannii is a gram-negative opportunistic bacterium that causes life-threatening infections in immunocompromised hosts. The complement system is a critical mechanism of innate immunity that protects the human body from bacterial infections. Complement activation leads to the deposition of the membrane attack complex (MAC), which can directly lyse gramnegative bacteria.

Background: Atrial fibrillation (AF) is the most common arrhythmia worldwide and the majority of AF patients are treated in primary care. In order to minimize hospitalizations and visits to emergency departments, nurse-led care was introduced in secondary care and primary health care (PHC). However, even though nurse-led care was initiated in PHC almost a decade ago, and ESC guidelines recommended

Background: Human milk offers significant health benefits for infants; however, when not feasible, infant formula serves as an alternative. The higher protein content in infant formula is thought to contribute to the distinct metabolic profiles observed in formula-fed infants compared with those fed human milk. Objectives: This study investigates the impact of formula protein quantity and whey pro

Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease. Several studies have identified transcriptional subtypes of mCRPC, but comprehensive analysis of prognostic gene expression pathways has been limited. Therefore, we aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression-based pathways with clinical out

We have calculated redox potentials of 12 blue copper protein sites comparing 64 computational methods, systematically varying the quantum mechanics (QM) system size, dielectric constants, density functional, and basis sets. All methods were based on structures optimized with combined QM and molecular mechanics (QM/MM) approaches. The redox potentials were evaluated using 10 quality metrics. The b

This study explores a collaborative project between various levels of public administration in southern Sweden, designed to encourage companies to adopt sustainable transportation practices. Conducted with the participation of researchers from Lund University, the project supports companies in developing and annually revising action plans that include specific sustainability goals, assigned respon

To reverse biodiversity loss, creating resilient ecological networks has been promoted in policy and practice. However, we argue that emphasising networks within policy without clear conservation prioritisations may direct focus away from ecological processes important for population persistence. We studied the rationale for resilient ecological networks represented in a policy context, by reviewi

Aims: This study surveyed individuals and caregivers of children who received teplizumab at stage 2 type 1 diabetes (T1D) to garner real-world experiences and their health outlook for the future following treatment with the first approved disease-modifying immune therapy for delaying the onset of Stage 3 T1D. Materials and Methods: This was a cross-sectional, observational, online survey (conducte

Background: Survivors of stroke commonly report sleep disturbances. Studies of sleep disturbances after stroke are mostly performed in the acute phase. An increased knowledge of sleep disturbances and its determinants a longer time after stroke is needed to improve treatment and rehabilitation. Objective: To assess survivors of stroke more than 1 year after stroke onset and (1) investigate self-re

The quantum prepare-and-measure scenario has been studied under various physical assumptions on the emitted states. Here, we first discuss how different assumptions are conceptually and formally related. We then identify one that can serve as a relaxation of all others, corresponding to a limitation on the one-shot accessible information of the state ensemble. This motivates us to study the optima

Background: Single-photon emission computed tomography (SPECT) devices equipped with cadmium–zinc–telluride (CZT) detectors achieve high contrast resolution because of their enhanced energy resolution. Recently, thallium bromide (TlBr) has gained attention as a detector material because of its high atomic number and density. Purpose: This study evaluated the clinical applicability of a SPECT syste

Purpose: This paper aims to explore Swedish municipalities’ adoption of politically decided goals and targets, within the budget document, that are formulated for the accounting unit of the municipal group. Design/methodology/approach: A regression analysis of the adoption of financial and non-financial performance measurement by 289 Swedish municipalities was performed, including eight independen