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MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occ
Type 1 diabetes, formerly known as juvenile diabetes or insulin-dependent diabetes, results from the specific autoimmune destruction of the pancreatic islet beta cells. The subsequent loss of insulin leads to increased blood and urine glucose. The classical symptoms are polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger), and weight loss. The disease may be
Gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, liver, and colorectal malignancies, represent a major global health burden due to their high incidence, aggressive nature, and limited treatment outcomes. This review explores the therapeutic potential of carvacrol, a naturally occurring monoterpenoid phenol predominantly found in oregano and other aromatic plants. Carvacrol
Samhällsinformation är ett kärnuppdrag. Gränserna för vad det innebär beror på ett biblioteks omgivning. "Det innebär dock inte att bibliotek bör göra allt", skriver bibliotekschefer och forskare.
Background: Ageing-in-place policies have increasingly shifted elder care responsibilities onto family members. Among older cohabiting couples, one’s partner’s illness significantly impacts the other’s daily life and well-being.Aim: To explore the responsibilities and strategies of caregiving partners in older cohabiting couples from the perspectives of cohabiting caregivers.Methods: A qualitative
Introduction: Taxonomic instability within the dynamic gut microbiome of very preterm infants can be associated with various adverse outcomes. This longitudinal study was designed to follow the trajectory of microbiome composition and abundance in a cohort of probiotic supplemented very preterm infants with and without sepsis. Methods: Stool samples (n = 180) from probiotic-supplemented participan
The Value of Information from Bayesian decision theory can be used to drive decisions within the development of new technologies aiding research screening, technology characteristics, and employment optimization. The selection of a specific application of technology leads to the definition of the decision scenario within the Value of Information framework. Technological performance characteristics
Vacuum impregnation (Ⅵ) is a versatile processing technique that enhances the nutritional and functional properties of fruits and vegetables by infusing bioactive compounds into their porous structures. This study demonstrates the utility of Ⅵ for fortifying fresh mango with β-carotene, a critical nutrient for addressing vitamin A deficiency, and for mitigating nutrient loss during solar drying. F
Based on ethnographic observations, this article seeks to empirically illustrate how one of the main functions of the Smart City Expo in Barcelona in 2024 is to perform smartcity-as-ideology and its technological-solutionist stance that considerably narrows our understanding of urban problems and the solutions for it. The article introduces the Expo and describes our arrival and visit to the Expo.
Objective: To investigate the expression and clinical significance of DNA helicase RecQL1 in cervical carcinoma and cervical intraepithelial neoplasia(CIN). Methods: The expression of DNA helicase RecQL1 were determined with reference to clinicopathological features and patient survival. 75 cervical carcinoma, 60 CIN and 20 normal control cases were collected for immunohistochemical analysis. Resu
Objective: To investigate the expression of Pyruvate dehydrogenase kinase 1(PDK1), phosphorylated Pyruvate dehydrogenase (p-PDH) and Pyruvate kinase isozyme type M2 (PKM2) based on Warburg effect pathway in cervical cancer tissues, and explore the roles of these molecules on prognosis and recurrence after postoperative radiation. Methods: The expressions of PDK1, p-PDH and PKM2 in primary tissues
Precisely determining the oxidation states of metal cations within variable-valence transition metal oxides remains a significant challenge, yet it is crucial for understanding and predicting the properties of these technologically important materials. Iron oxides, in particular, exhibit a remarkable diversity of electronic structures due to the variable valence states of iron (Fe 2+ and Fe 3+). A
During the last decade the intersection between social welfare research and the ecological crisishas been gaining increasing interest through discussions about sustainable welfare and eco-social policies. Less attention has been paid, however, to eco-social risks and to how climatechange “will impact the nature and distribution of social risks across di!erent parts of thepopulation” (Hirvilammi et
Presentationen rör barn och ungas vardagliga geografier samt det sociala arbetets etablerade förhållningssätt till desamma. Särskilt fokus kommer riktas mot hur erfarenhetsnära tolkningar av barn och ungas egna berättelser om ”den vanliga vardagen” kan utvidga det sociala arbetets förståelse för barn och ungas geografier, och hur dessa tolkningar kan be
Om assassinerna.
Hjärtat består av fyra hålrum; två kammare och två förmak, som separeras av fyra hjärtklaffar. Dessa säkerställer att blodet enbart flödar åt ett håll och ger därmed hjärtat förutsättningarna för effektiv pumpning av blodet. Mitralisklaffen är en av dessa fyra hjärtklaffar och separerar vänster förmak från vänster kammare, vilket gör att den utsätts för det högsta trycket i hjärtat. För att mitralThe heart consists of four chambers, two atria and two ventricles, separated by four valves that ensure unidirectional blood flow and efficient cardiac function. Among these, the mitral valve regulates blood flow between the left atrium and left ventricle and is one of the most mechanically loaded structures in the heart, stabilized by the chordae tendineae, which are connective structures. Conseq
The eighteenth century marks a watershed in European intellectual history. It witnessed the development of many civil rights ideas that were prerequisites for the emergence of modern political systems. One principle that appears to be supported by numerous empirical examples is that evolving political pluralism fostered the right to express one’s views with a certain degree of freedom. This articl
From the perspective of the Swedish education system, rural knowledge does not seem to be particularly important. Many young people in rural areas have deep and important knowledge that is invisible in school and during school time, both to teachers and to the young people themselves. This paper examines knowledge used in agriculture and animal husbandry, a type of knowledge that is particularly uFrom the perspective of the Swedish education system, rural knowledge does not seem to be particularly important. Many young people in rural areas have deep and important knowledge that is invisible in school and during school time, both to teachers and to the young people themselves. This paper examines knowledge used in agriculture and animal husbandry, a type of knowledge that is particular
This forum discusses and celebrates the career and impact of Jens Bartelson in and on Nordic academic International Relations. Through engagement with his central works and concepts, the contributions highlight the intellectual impact and development of Bartelson’s work over three decades.
