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Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM

In the current work, we present a topology optimization framework for designing periodic microstructures with viscoplastic constitutive behavior under finite deformation. Materials with tailored macroscopic mechanical properties, i.e. maximum viscoplastic energy absorp- tion and prescribed Poisson's ratio, are designed by performing numerical tests of a single unit cell subjected to periodic bound

A hierarchical multiscale model that couples a region of material described by discrete dislocation plasticity1 to a surrounding region described by conventional crystal plasticity is presented. The coupled model captures size-dependent plasticity phenomena, such as dislocation structuring and formation of geometrically necessary dislocations, that can occur at the micron scale while also capturin

Introduction: A large body of research has established a consensus that racial discrimination in CV screening occurs and persists. Nevertheless, we still know very little about how recruiters look at the CV and how this is connected to the discriminatory patterns. This article examines the way recruiters view and select CVs and how they reason about their CV selection choices, as a first step in u

Although direct migration flows from Sweden to Portugal have been marginal, the actual number of citizens from Sweden living in Portugal continues to increase every year. Many Swedes appear to move to Portugal via a third country. By far the largest number of Swedish citizens permanently residing in Portugal settles on the Algarve or in the Lisbon area, generally close to their compatriots. Those

This paper re-introduces the view on migration causes by the Austrian School of Economics. Austrian economics has not earned its fame in the field of migration, but rather on advocating libertarian economics. Nonetheless Mises outlined a migration model, which can be understood by adding some clarifications by Hayek. Given that the institutional barriers to migration raised by the state are remove

To what extent territorial cohesion is achieved or not, due to the EU Cohesion Policy, national regional policies, or globalization forces, is debated. This paper aims at discussing territorial cohesion at a NUTS 3 level in Denmark, Finland, Norway and Sweden for 2007 and 2017 by using the Territorial Cohesion Development Index. The findings indicate a) that bigger cities and highly urbanized regi

This article discusses the drivers behind why Swedes move to Portugal and who these migrants are. The conceptual framework is based on lifestyle migration and considers migration as a process. Using a semi-structured interview guide, designed according to a life-course approach, 36 in-depth interviews with Swedes permanently residing in Portugal were conducted. The findings display that only a sma

This article discusses the self-perceived integration of Swedes permanently residing in Portugal. The knowledge of how EU citizens, particularly Swedes, live and integrate into Portuguese society is limited. The conceptual framework on self-perceived integration takes its points of departure from the concepts of a sense of belonging to society and place, feelings of discomfort and coping tactics.

This paper aims to explicate and discuss the main methods of measuring the effects of place marketing. Rather than favouring one method over another a priori, we seek to understand each method on its own terms in order to illuminate key assumptions and hypotheses. Additionally, we compare and contrast the different methods to reveal areas of logical inconsistency.Generally, the impact of place mar

This article offers a theoretical discussion on the role of informal institutions in the integration process of immigrants to a new country. Previous research on how immigrants become integrated and assimilated into the host countries demonstrates that integration/assimilation takes long time, often occurring over several generations; formal institutions matter; such theories are good at explainin

This paper aims at identifying the current main economic thought influencing the EU Cohesion Policy. Postulates and assumptions on how economic growth spreads spatially in key EU policy framework documents are discussed and compared to different economic theories. Strategic EU documents increasingly foster the urban dimension, and focus resources on cities at the expense of cohesive regional devel

This paper discusses the role of medium towns as crucial anchors in achieving the policy goal of Territorial Cohesion. It highlights the need to counterbalance market trends to favour the continuous channelling of investment and people into larger metropolitan areas by way of proactive measures focused on attracting investment into medium towns, and as an alternative to dispersing public and priva

In the present article we explore when, where, and how Swedish sexual minority women experience minority stress and microaggression. Drawing on deductive thematic analysis of forty-eight interviews, we show that minority stress and microaggressions were experienced in a wide range of everyday life areas. Exposure was described in the forms of physical violence, threats and verbal abuse, ignorance

SARS-CoV-2 non-structural protein 10 (nsp10) is essential for the stimulation of enzymatic activities of nsp14 and nsp16, acting as both an activator and scaffolding protein. Nsp14 is a bifunctional enzyme with the N-terminus containing a 3'-5' exoribonuclease (ExoN) domain that allows the excision of nucleotide mismatches at the virus RNA 3'-end, and a C-terminal N7-methyltransferase (N7-MTase) d