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In order to increase the understanding of suicidal behaviour, the general aim of the thesis is to gain a profound knowledge of the suicidal individual, and hence to find and ensure a preventive strategy. This will be accomplished by finding and trying new methods for evaluation of suicide risk. The Suicide Assessments Scale, SUAS, and a new self-rating version, SUAS-S were tested. These scales ar
Head and neck cancer is a heterogeneous group of tumours, although histopathologically, >95% are squamous cell carcinomas (SCC). Some tumours respond better to therapy than others. Not enough is known to predict the outcome and tailor individualised treatment. Although one of the main risk factors, smoking, has decreased over the last decades, some head and neck cancer groups show increasing incid
Popular Abstract in Swedish Denna sammanläggningsavhandling i fysisk planering visar hur viktig rättens och juridikens roll är för planeringen och styrning av landskap och miljö, och de fall som studerats och analyserats är den svenska utbyggnaden av 3G-infrastruktur och vindkraften. Utifrån ett rättssociologiskt planeringsperspektiv visar Stefan Larsson (som också disputerat i rättssociologi tidiThis PhD thesis in Spatial Planning argues for the importance of understanding the approaches to knowledge and rationalities embedded in spatially relevant decision-making. It emphasises the significance of seeing law as an empirical object of study for planning and environmental management. The Swedish development of wind power and 3G mobile infrastructures are used as cases to study these issues
The urinary bladder is responsible for storage and expulsion of urine. Proper urination depends on an ability of the bladder to adjust to increasing volume and to contract during micturition. A disturbance of bladder contractility may affect continence. In the present thesis I have used genetic, biochemical and physiological approaches to examine the role of caveolae and mircoRNAs in bladder funct
Photosynthesis is performed by a multitude of organisms, but in P nearly all cases, it is variations on a common theme: absorption of light followed by energy transfer to a reaction center where charge separation takes place, This initial form of chemical energy is stabilized by the biosynthesis of carbohydrates. To produce these energy-rich products, a substrate is needed that feeds in reductive
Popular Abstract in Swedish Framtida klimatförändringar påverkas till stor del på människans utsläpp av CO2, samt av klimat- och CO2-relaterade återkopplingar genom kolcykeln i både landbaserade ekosystem och hav. Landbaserade ekosystem tar för tillfället upp omkring 25% av de antropogena utsläppen av CO2 från förbränning av fossila bränslen och markanvändning, men att tillskriva vilka mekanismer The nature of future climate change will depend on anthropogenic emissions of CO2, as well as climate- and CO2-mediated feedbacks through carbon (C) cycling in both terrestrial ecosystems and oceans. Terrestrial ecosystems remove presently about 25% of the anthropogenic CO2 fossil-fuel and land-use change emissions, but to attribute which mechanisms cause this uptake, and the key regions where it
The Zeeman interaction in low-dimensional III-V semiconductor nanostructures is studied. The effective g-value of bulk InGaAs is measured by two different spin resonance techniques. Experimental conditions were found to control the Overhauser effect, thus enabling a highly accurate determination of the g-value, g* = -4.070 ± 0.005, being a prerequisite for theoretical modeling of low-dimensional
Popular Abstract in Swedish Därför får man sockersjuka (Felix Mulder, 6 år): ”Det är inte bra att äta för mycket socker. Socker är vasst och skär sönder blodkropparna. Då kan man inte göra insulin och man blir sjuk.” Islet amyloid polypeptide (förkortat: IAPP) är ett medelstort äggviteämne - peptid - som upptäcktes 1986 av Per Westermark i Uppsala. Denna upptäckt har en intressant bakgrund. Det hIslet amyloid polypeptide (IAPP; also named ”amylin”) is a member of the calcitonin superfamily of peptides, displaying the closest structural relationship to the neuropeptide calcitonin gene-related peptide (CGRP). It is expressed in islet beta-cells and forms islet amyloid in type 2 diabetic patients. IAPP may restrain release and peripheral actions of insulin. Thus, IAPP has been implicated in
Popular Abstract in Swedish När vi ser oss omkring i naturen är det lätt att överväldigas av den otroliga variationen i olika former, färger och mönster som förekommer. Var kommer all denna variation ifrån? Samma fråga ställde sig Charles Darwin för mer än 150 år sedan – svaret publicerade han 1859 i sin bok ”Om arternas uppkomst”. Evolution är den process som genom selektion gynnar vissa egenskapOur knowledge of the evolutionary potential of traits involved in different selective episodes, especially in natural populations, is still limited. This is true for questions such as the genetic basis and inheritance of traits, how natural and sexual selection acts on them, and how selective conflicts influence the evolutionary response to selection. In my thesis, I investigate these questions, u
The red admiral (Vanessa atalanta) is a migratory butterfly that can be found in North America, North Africa, Europe and some parts of Asia. In Europe the main part of the population spend winter in the Mediterranean region and the following spring leave this area to breed further to the north. At least one new generation is then produced in the summer region before they return to the south again
The gene fusion technique is widely used in protein engineering and in this thesis it constitutes the basis of both the construction of artificial bifunctional enzymes and the display of two novel peptides. Artificial bifunctional enzymes have been used as model systems in the studies of native multifunctional enzymes and proximity effects within these complexes. Two various constructs are descri
Purpose: Contribution to the understanding of defensive routines within the context of Landora Färgindustri. Research question: What are the explanatory factors behind defensive routines facing an individual within the context of their situational environment at Landora. Methodology: Mixed methods with triangulation, deduction, qualitative and quantitative methods are used. Conceptual Framework: T
This thesis deals with the carbon balance in a subarctic landscape at different temporal and spatial scales. Its focus is mainly on the peatland and mountain birch forest (Betula pubescens ssp. czerepanovii) ecosystems within the Abisko area in northernmost Sweden. This is an area with a temperature close to the 0 OC mean annual isotherm. The area has during the last 30 years experienced a limited
Background: The Southern Swedish Malignant Melanoma (SSMM) research team is a truly cross functional group with members from oncology, clinical, surgery, bioinformatics, proteomics, and genomics initiatives. The SSMM’s objectives and goals are to develop, build and utilize cutting edge biobanks and OMICS platforms to better understand disease pathology and drug mechanisms. Within the research team
Amorphous Silica (ASi) is present in considerable amounts in most soils and serves as a (micro-)nutrient for many plants. However, our understanding of the response of this important nutrient pool to human or natural disturbances is still very limited. One of the reasons for this is the long time scales involved. This explorative study focuses on the effect of a historical agricultural system, cal
Thermal-optical analysis is a conventional method for determining the carbonaceous aerosol fraction and for classifying it into organic carbon, OC, and elemental carbon, EC. Unfortunately, the different thermal evolution protocols in use can result in a wide elemental carbon-to-total carbon variation by up to a factor of five. In Europe, there is currently no standard procedure for determining the
