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On the antiporter-like subunits of respiratory chain Complex I - implications for the evolution and coupling mechanism of the NADH:quinone oxidoreductase enzyme complex

Popular Abstract in Swedish Evolusjon og energikonservering i en katalysator i cellens kraftverk Alle levende organismer må omforme energien i mat eller sollys til en form som cellen kan bruke som energi. Energien brukes både til prosesser som bryter ned og bygger opp komponenter i cellen. Den brukes også til prosesser som muskelsammentrekninger, celledelinger og bevegelser. Uansett hva slags cel

Fluvial transport and risk of mercury in a gold mining area

My thesis is part of an overall environmental program evaluating the environmental and human health stress in areas of Nicaragua affected by anthropogenic emission of metals and man-made organic substances. I examine the fluvial transport of mercury contextually associated with the extent of the contamination and the observed human and environmental stress in a gold mining area. Field measurements

Magnesium Chelatase: Insights into the first Step of Chlorophyll Biosynthesis

Popular Abstract in Swedish Enzymet magnesium-kelatas katalyserar bildandet av magnesium-protoporfyrin genom insättning av en magnesiumjon i protoporfyrin. Detta är det första unika steget i tillverkningen av klorofyll hos växter, alger och fotosyntetiska bakterier. Magnesium-kelatas består av tre proteiner som kallas I (vikt 40 kDa), D (70 kDa) och H (140 kDa). Det är viktigt att bestämma dessa pThe enzyme magnesium chelatase inserts magnesium into protoporphyrin IX (Proto) to produce to magnesium protoporphyrin IX, the first unique intermediate of the chlorophyll biosynthetic pathway. Magnesium chelatase is composed of three distinct proteins termed I (molecular weight ~40 kDa), D (~70 kDa) and H (~140 kDa). Defining the individual properties and structure of the magnesium chelatase comp

Holocene environmental change in Kamchatka: A synopsis

We present a synthesis of the results of a multiproxy, multisite, palaeoecological study of Holocene environmental change in Kamchatka, Far East Russia, details of which are presented elsewhere in the volume. We summarise the results of the analyses of pollen, diatom, chironomid, and testate amoebae assemblages, together with stable isotopes of oxygen and carbon, and sediment characteristics from

A deglacial palaeomagnetic master curve for Fennoscandia Providing a dating template and supporting millennial-scale geomagnetic field patterns for the past 14 ka

Reconstructions of palaeomagnetic secular variation (PSV) in sediment cores can be compared to well-dated regional PSV master curves to infer deposition age. The existing PSV master curve for Fennoscandia, "Fennostack" (Snowball et al., 2007), is limited to the past 10 ka. In this study, we construct a deglacial (for the interval 14-11 ka) PSV master curve for Fennoscandia by including data from a

Coupling carbon allocation with leaf and root phenology predicts tree–grass partitioning along a savanna rainfall gradient

The relative complexity of the mechanisms underlying savanna ecosystem dynamics, in comparison to other biomes such as temperate and tropical forests, challenges the representation of such dynamics in ecosystem and Earth system models. A realistic representation of processes governing carbon allocation and phenology for the two defining elements of savanna vegetation (namely trees and grasses) may

The Phylogenetic Distribution and Evolution of Enzymes Within the Thymidine Kinase 2-like Gene Family in Metazoa

Deoxyribonucleoside kinases (dNKs) carry out the rate-determining step in the nucleoside salvage pathway within all domains of life where the pathway is present, and, hence, are an indication on whether or not a species/genus retains the ability to salvage deoxyribonucleosides. Here, a phylogenetic tree is constructed for the thymidine kinase 2-like dNK gene family in metazoa. Each enzyme class (d

Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families

Introduction: A significant proportion of high-risk breast cancer families are not explained by mutations in known genes. Recent genome-wide searches (GWS) have not revealed any single major locus reminiscent of BRCA1 and BRCA2, indicating that still unidentified genes may explain relatively few families each or interact in a way obscure to linkage analyses. This has drawn attention to possible be

Analysis of the highly diverse gene borders in Ebola virus reveals a distinct mechanism of transcriptional regulation.

Ebola virus (EBOV) belongs to the group of nonsegmented negative-sense RNA viruses. The seven EBOV genes are separated by variable gene borders, including short (4- or 5-nucleotide) intergenic regions (IRs), a single long (144-nucleotide) IR, and gene overlaps, where the neighboring gene end and start signals share five conserved nucleotides. The unique structure of the gene overlaps and the prese

Structural characterization of human galectin-4 C-terminal domain : Elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

Human galectin-4 is a lectin that is expressed mainly in the gastrointestinal tract and exhibits metastasis-promoting roles in some cancers. Its tandem-repeat nature exhibits two distinct carbohydrate recognition domains allowing crosslinking by simultaneous binding to sulfated and non-sulfated (but not sialylated) glycosphingolipids and glycoproteins, facilitating stabilization of lipid rafts. Cr

TransCom N2O model inter-comparison : part 1 : assessing the influence of transport and surface fluxes on tropospheric N2O variability

We present a comparison of chemistry-transport models (TransCom-N2O) to examine the importance of atmospheric transport and surface fluxes on the variability of N2O mixing ratios in the troposphere. Six different models and two model variants participated in the inter-comparison and simulations were made for the period 2006 to 2009. In addition to N2O, simulations of CFC-12 and SF6 were made by a

Contrasting changes in taxonomic, phylogenetic and functional diversity during a long-term succession: insights into assembly processes

1. Theory predicts that the processes generating biodiversity after disturbance will change during succession. Comparisons of phylogenetic and functional (alpha and beta) diversity with taxonomic diversity can provide insights into the extent to which community assembly is driven by deterministic or stochastic processes, but comparative approaches have yet to be applied to successional systems. 2.

The ecological impact of oceanic island colonization - a palaeoecological perspective from the Azores

Aim In many cases, human colonization drastically modified the ecosystems of remote oceanic islands before scientists arrived to document the changes. Palaeoecological records before and after human colonization provide insights into the original ecosystems and an assessment of subsequent human impact. We used pollen analysis to compare the impact of 15th century colonization of the Azores with th

Effects of surface characteristics on infiltration patterns in an arid shrub desert

Precipitation is often the sole source of water replenishment in arid and semi-arid areas and, thus, plays a pertinent role in sustaining desert ecosystems. Revegetation over 40 years using mainly Artemisia ordosica and Caragana korshinskii at Shapotou Desert Experimental Research Station near Lanzhou, China, has established a dwarf-shrub and microbiotic soil crust cover on the stabilized sand dun

Primary production of Inner Mongolia, China, between 1982 and 1999 estimated by a satellite data-driven light use efficiency model

Declining biological production as a part of an ongoing land degradation process is considered a severe environmental problem in the dry northern and northwestern regions of China. The aim of this study is to develop and adapt a satellite data-driven gross primary production model called Lund University light use efficiency model (LULUE) to temperate conditions in order to map gross primary produc

EGF-stimulated migration in ovarian cancer cells is associated with decreased internalization, increased surface expression, and increased shedding of the urokinase plasminogen activator receptor.

Objectives. The EGFR is expressed in malignant ovarian tumor tissue, and tissue content of EGFR has been directly associated with poor prognosis in patients with ovarian cancer. The uPA system plays a role in pericellular proteolysis, cell migration, invasion, and is over-expressed in ovarian cancer. This study explored the effects of EGF on uPAR expression in the ovarian cancer cell line OVCAR-3.

Calcium deposition and expression of bone modelling markers in the tympanic membrane following acute otitis media

Background and objectives In accordance with clinical findings, myringoscterosis develops after otitis media (OM) and paracentesis in an experimental setting. The pathogenesis of this phenomenon of calcification is poorly understood. As the calcification process and the sclerotic plaques of the drum mimics features of bone tissue, this study explores tympanic membrane calcium deposition in associa

Arsenic mobilisation in a new well field for drinking water production along the Red River, Nam Du, Hanoi

Arsenic enrichment of groundwater in the Red River (Song Hong) delta in Vietnam was discovered in 1998. Several studies performed in this area found concentrations of As exceeding the WHO-guideline of 10 lg/L. This study focuses on an area south of Hanoi city, Nam Du, where a new well field came into operation in 2004. The new well field is situated on the bank along the Red River in order to faci

Selected research studies from Scandinavia : dedicated to professor Göran Fagerlund on his 60th anniversary November 11, 1997

The book contains selected articles from research in different areas produced by scientists in Scandinavia. However, many of the articles are based upon professor Göran Fagerlund's original ideas. Titles:

1.Cementitious injection grouts - penetration ability (Alemo, J. & Hansson, P.).
2.A disadvantage of high performance concrete and a simple way to avoid it (Alexanderson, J).

Automatic segmentation in CMR - Development and validation of algorithms for left ventricular function, myocardium at risk and myocardial infarction

Popular Abstract in Swedish I denna avhandling presenteras fyra nya metoder för att automatiskt mäta hjärtats förmåga att pumpa ut blod i kroppen, mäta storleken på en hjärtinfarkt samt mäta hur stor del av hjärtmuskeln som riskerade att dö vid hjärtinfarkten. Dessa nya metoder kan användas för att minska skillnader mellan mätningar gjorda av olika läkare, på olika sjukhus och i olika forskargruppIn this thesis four new algorithms are presented for automatic segmentation in cardiovascular magnetic resonance (CMR); automatic segmentation of the left ventricle, myocardial infarction, and myocardium at risk in two different image types. All four algorithms were implemented in freely available software for image analysis and were validated against reference delineations with a low bias and hig