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Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (6
Aim: Extremes in sleep duration play an important role in the development of type 2 diabetes. We examined the associations between sleep duration and sleep debt with estimates of insulin sensitivity and insulin secretion. Methods: Data were derived from the European multi-centre EGIR-RISC study. Sleep duration and sleep debt were derived from a sleep questionnaire asking about sleeping time during
An approach to reduce CO2 emissions while simultaneously keeping the soot emissions down from compression ignition (CI) engines is to blend in short chained oxygenates into the fuel. In this work, two oxygenated fuel blends consisting of diesel, gasoline and ethanol (EtOH) in the ratio of 68:17:15 and 58:14:30 have been utilized and studied in a single cylinder light duty (LD) CI engine in terms o
Background-Diabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown. Methods and Results-We used shotgun mass spectrometry to determine serum levels of 255 molecular lipids in 316 controls, 171 DM, and 99 myocardial infarction (MI) events from a cohort derived from the Malmö Diet and Cancer study.
A new method to determine the concentration of the free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assay is possible due to the high affinity (Kd = 0.1 nM) of the interaction betwe
OBJECTIVES: To examine costs and effects of care based on comprehensive geriatric assessment (CGA) provided by an ambulatory geriatric care unit (AGU) in addition to usual care.DESIGN: Assessor-blinded, single-center randomized controlled trial.SETTING: AGU in an acute hospital in southeastern Sweden.PARTICIPANTS: Community-dwelling individuals aged 75 years or older who had received inpatient hos
Summary. This review describes the background for the development of recombinant FVIIa (rFVIIa; NovoSeven) for use in haemophilic patients with inhibitors. The first proof of principle for using pharmacological doses of FVIIa as a haemostatic agent was obtained by producing small amounts of pure plasma-derived FVIIa, which showed encouraging effect in two patients with haemophilia A and inhibitors
For historical reasons, Swedish railways use 15 kV/16? Hz overhead contact lines for train traction, while the most common standard worldwide is 25 kV/50-60 Hz. This leads to higher investment costs for railway conversions and expansions, and to greater energy losses in the distribution of electricity to the trains. Yet to get away from these drawbacks by investing in a 25 kV/50 Hz overhead contac
Det ökade användandet av träbaserade volymelement i flerfamiljshus kräver effektiva och detaljerade beräkningsmetoder. Numeriska modeller av volymelementen ger stora fördelar med avseende på analys av stabilitet mot vindlaster genom möjligheten att beakta hela den tredimensionella konstruktionens styvhet.The use of timber volume elements (TVEs) in residential multi-storey buildings is increasing in popularity. Manufacturing methods and building processes have been streamlined to improve product quality. However, further streamlining still remains concerning the efficiency of current calculation methods, as many developers still use simple hand calculations. The objective with this dissertation was
A mysterious gene found in many bacteria Recently, a gene called ctaM was discovered in Staphylococcus aureus, a common cause of skin infections etc., required for the bacterium to respire efficiently. It was demonstrated that the protein encoded by this gene is essential for the function of cytochrome aa3, that catalyzes the reduction of O2 to form H2O in respiration. A gene encoding a similar p
Skattelagstiftning styrs av principer, som ibland kan säga emot varandra och då behöva vägas mot varandra. I förarbeten redogör lagstiftaren för hur denna bedömning ser ut, och det är möjligt att genom förarbeten analysera vilka principer lagstiftaren behandlar, hur de behandlas och hur de vägs mot varandra. Det finns olika sätt att dela in skatterättsliga principer; ett sätt är att dela in dem i Tax law is governed by principles, that sometimes may contradict each other and then need to be weighed against each other. In preparatory works the lawmaker gives their account for how the assessment of principles looks like, and it’s possible through preparatory works to analyse which principles the lawmaker considers, how they’re considered, and how they’re weighed against each other. There are
Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects. Methods We performed a two-stage meta-analysis on more than 78 000 participants. In stage 1, we synthesised data from eight GWAS whereas data from 10 centres wer
Sandvik Rock Processing in Svedala is a business area within the Sandvik Group who manufactures crushers and spare parts. A new production plant, Greenfield, will be completed in 2013 and as part of the change the company makes in connection with the new plant, there is a desire to revise and optimize the order quantities in the production. There are several models for lot sizing. Economic Order Q
Reppe, a starch factory within the concern of Lantmännen is mainly producing starch from wheat but also gets gluten as a product in the process. Currently, the wheat gluten is primarily used to improve the properties of flour for bread-making and as an additive in the baking industry. But there is an interest to explore new uses of the product. To make this possible, the solubility of gluten has t
This master thesis work comprises 20 academic credits (20 weeks) and was carried out in a time period beginning autumn 2004 ending early 2005 at the department of Industrial Management and Logistics under the division of Production Management at Lund Institute of Technology (LTH) in cooperation with IdeonCenter AB. The problem being investigated was how to measure the development of the new techno
Forskare tar helhetsgrepp om inomhusmiljön – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Forskare tar helhetsgrepp om inomhusmiljön 2014-09-02 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Foto: Colourbox – Vi tillbringar nittio procent av tiden inomhus
https://www.vetenskaphalsa.se/forskare-tar-helhetsgrepp-om-inomhusmiljon/ - 2026-05-29
Alkohol- och rökstopp minskar riskerna för komplikationer vid operation – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Alkohol- och rökstopp minskar riskerna för komplikationer vid operation 2018-01-17 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Det är
https://www.vetenskaphalsa.se/alkohol-och-rokstopp/ - 2026-05-28
The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update PATHOGENESIS OF TYPE 1 DIABETES (A PUGLIESE AND SJ RICHARDSON, SECTION EDITORS) The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update Marian Rewers1 & Heikki Hyöty2,3 & Åke Lernmark4 & William Hagopian5 & Jin-Xiong She6 & Desmond Schatz7 & Anette-G Ziegler8 & Jorma Toppari9 & Beena Akolk
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/97%2001252019_679_097_REVIEW_Rewers_CurrDiabRpts_2018.pdf - 2026-05-30
Topicalization: The IO/DO Asymmetry in Icelandic* Elena Callegari and Anton Karl Ingason University of Iceland Abstract In this paper, we investigate differences in the frequency of direct-object versus indirect-object topicalization (i.e. fronting with no accompanying pronom- inal resumption) in Icelandic using the Icelandic Parsed Historical Corpus. We find that the overall incidence of DO topic
