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Identification of COL1A1/2 Mutations and Fusions With Noncoding RNA Genes in Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion)

Bizarre parosteal osteochondromatous proliferation (BPOP) (Nora lesion) is a benign bone surface lesion, which most commonly occurs in the digits of young patients and has a high rate of recurrence. Histologically, it is composed of a mixture of disorganized bone, cartilage, and spindle cells in variable proportions and characterized by amorphous "blue bone" mineralization. Recurrent chromosomal a

Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia

The aim of this study was to investigate whether consumption of a newly developed oat milk deprived of insoluble fiber would result in lower serum cholesterol and low-density lipoprotein (LDL) cholesterol levels in men with moderate hypercholesterolemia. The study had a randomized, controlled double-blind design, and oat milk was compared with an identically flavored control drink. Sixty-six men w

Fast and sensitive validation of fusion transcripts in whole-genome sequencing data

BACKGROUND: In cancer, genomic rearrangements can create fusion genes that either combine protein-coding sequences from two different partner genes or place one gene under the control of the promoter of another gene. These fusion genes can act as oncogenic drivers in tumor development and several fusions involving kinases have been successfully exploited as drug targets. Expressed fusions can be i

Long-term life-history responses to climate change in the willow warbler (Phylloscopus trochilus)

Birds, and especially long-distance migrants, are excellent indicators of climate-induced phenological change. Advanced spring arrival is a typical response reported in a great number of species. Earlier arrival can lead to e.g. earlier egg-laying and thus have potentially great fitness consequences. Studies have suggested that certain aspects of avian life-history can predict a likely response to

Reproducibility of measurements with a semi-automatic software package for the evaluation of rectal cancer

Background: Staging of rectal cancer with MRI has major impact on treatment choice and may be of importance in new cancer management strategies such as “wait-and-see” policy. Purpose: To assess the reproducibility of a software package recently developed at our department to measure volumes, apparent diffusion coefficient, and the skewness of apparent diffusion coefficient in lymph nodes and tumor

Professional judgements in collaboration

Although intimate partner violence is far from a new problem in society, it has lately gained increased attention both by governments and by the research community. In 2007, the Swedish government issued an action plan for “combating men’s violence against women, violence and oppression in the name of honour and violence in same-sex relationships” (2007/08:39), which included a call for increased

Botanizing the Asphalt : Politics of Urban Drainage

Modern cities are often perceived as the antithesis of nature; the built environment is understood as the transformation of raw and untamed nature into a rationalized human landscape. However, a variety of scholars since the nineteenth century have noted the persistence of nature in cities, not only in providing essential services but also resisting human control. Most recently, urban geographers

Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa

Background: Phylogeny construction can help to reveal evolutionary relatedness among molecular sequences. The spike (S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region. This study aimed to identify mutations in the S gene among SARS-CoV-2 sequences collected in the Middle East and North Africa (MENA), focusing on the D614G mutation,

Identifying and modelling clinical subpopulations from the Malmö breast tomosynthesis screening trial

Virtual Clinical Trials (VCT) are an effective tool to evaluate the performance of novel imaging systems using computer simulations. VCT results depend on the selection of virtual patient populations. In the case of breast imaging, virtual patients should be matched to a desired clinical population in terms of selected anatomical or demographic descriptors. We are developing a virtual population o

Genetic Variant Score and Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Plakophilin-2 Mutation Carriers

Introduction: Whether detailed genetic information contributes to risk stratification of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) remains uncertain. Pathogenic genetic variants in some genes seem to carry a higher risk for arrhythmia and earlier disease onset than others, but comparisons between variants in the same gene have not been done. Combined Annotation Dependent

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As the lightest commercial metal structure material, magnesium alloy shows a wide application prospect in aerospace, automobile, 3C pro-ducts and other fields. At the same time, it is of great strategic significance to promote the application of magnesium alloy materials, in the face of the increasing shortage of iron and aluminum resources in the world and the dilemma of a large number of importe

Remembering, forgetting and memorialising : 1947, 1971 and the state of memory studies in South Asia

The “cultural turn” in memory studies acknowledges that collective memory has a distinctive social aspect reflected in the manner in which it is communicated orally from one individual or generation to another. However, the point of departure is the emphasis on the need to account for the fact that memory is, in equal measure, shaped and mediated by tangible channels such as texts, images, objects

Functional evolution of a bark beetle odorant receptor clade detecting monoterpenoids of different ecological origins

Insects detect odors using an array of odorant receptors (ORs), which may expand through gene duplication. How and which new functions may evolve among related ORs within a species remain poorly investigated. We addressed this question by functionally characterizing ORs from the Eurasian spruce bark beetle Ips typographus, in which physiological and behavioral responses to pheromones, volatiles fr

Tubas, Tubists, and Composers : A mixed-methodological approach to performer- and composer-instrument relationships

This thesis assesses, through self-reflective practice, how the instruments of the tuba family have functioned as interfaces between composers and performers from the earliest records to the present day. A lack of knowledge surrounding the instruments and their capabilities and limitations has persisted since they were first employed by composers in the late seventeenth century, which suggests tha