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Familial aggregation and heterogeneity of non-Hodgkin lymphoma in population-based samples

The importance of genetic factors in the etiology of non-Hodgkin lymphoma (NHL) is suggested by case-control and cohort studies. Most previous studies have been too small to estimate accurately risks of specific categories of lymphoproliferative malignancies in relatives of NHL cases or to quantify the contribution of NHL case characteristics to familial risk. We have overcome sample size limitati

Spatiotemporal pattern of Wnt-canonical pathway in dorsal telencephalic organoids.

In the last decade, organoid technology has filled the gap generated by the poor accessibility and unique features of the human brain. Organoids present several advantages in comparison with two-dimensional culturing, since they recapitulate cytoarchitecture in space and functionality of the tissue. Therefore, they mimic the unique features of human brain better than animal models. Although signif

A Joint Desalination and Power Plants for Water and Development: A Case study of the Sinai-Gaza

Desalination can be a cost-effective way to produce fresh water and possibly electricity. The Gaza Strip has had a complex hydro-political situation for many years. Gaza (enclosed area) is bordered by the Mediterranean in the west, by Israel in the north and east and by Egypt in the south. Water and electricity consumption in the Gaza Strip is expected to increase in the future due to the increasi

Towards a Gender-Aware understanding of innovation : A three-dimensional route

Purpose – The purpose of this study is to discuss the theory of gender bias in innovation studies, to illustrate the gender bias of innovation studies by using empirical means and to suggest what is needed to reduce such bias. Previous studies on innovation have primarily focussed on male-dominated industries. These studies have been biased and hence unable to capture the range of innovations cove

Interfacial Structures of Trihexyltetradecylphosphonium-bis(mandelato)borate Ionic Liquid Confined between Gold Electrodes

Atomistic molecular dynamics simulations have been performed to study microscopic the interfacial ionic structures, molecular arrangements, and orientational preferences of trihexyltetradecylphosphonium-bis(mandelato)borate ([P6,6,6,14][BMB]) ionic liquid confined between neutral and charged gold electrodes. It was found that both [P6,6,6,14] cations and [BMB] anions are coabsorbed onto neutral el

Extended Producer Responsibility for Closing Material Loops: Lessons from energy-efficient lighting products

The transition to a low-carbon economy requires enabling technologies including energy-efficient lighting products. It is increasingly recognized that a sustainable economy is not only low-carbon and energy efficient, but also resource efficient. Previous research has highlighted the importance and need for increased collection and recycling of lamps, to reduce mercury emissions, to avoid unnecess

Validity and reliability of the Patient Health Questionnaire-8 in Swedish for individuals with systemic sclerosis

Background: Depressive symptoms are common in rheumatic diseases and influence patients’ quality of life. The Patient Health Questionnaire-9 (PHQ-9), which assesses symptoms of depression, is valid in English in patients with systemic sclerosis (SSc). However, the measurement properties of the PHQ-8 (short version of the PHQ-9) have not been evaluated in Swedish patients with SSc. Objective: To in

Quantitative study of coherent pairing modes with two-neutron transfer : Sn isotopes

Pairing rotations and pairing vibrations are collective modes associated with a field, the pair field, which changes the number of particles by two. Consequently, they can be studied at profit with the help of two-particle transfer reactions in superfluid and in normal nuclei, respectively. The advent of exotic beams has opened, for the first time, the possibility to carry out such studies in medi

The gut bacterial community affects immunity but not metabolism in a specialist herbivorous butterfly

Plant tissues often lack essential nutritive elements and may contain a range of secondary toxic compounds. As nutritional imbalance in food intake may affect the performances of herbivores, the latter have evolved a variety of physiological mechanisms to cope with the challenges of digesting their plant-based diet. Some of these strategies involve living in association with symbiotic microbes tha

The Malmö Offspring Study (MOS) : design, methods and first results

As cardio metabolic disease manifestations tend to cluster in families there is a need to better understand the underlying mechanisms in order to further develop preventive strategies. In fact, genetic markers used in genetic risk scores, important as they are, will not be able alone to explain these family clusters. Therefore, the search goes on for the so called missing heritability to better ex

Genetic and environmental determinants of peak bone mass in young men and women

Peak bone mass is an important risk factor for the development of osteoporosis in later life. Previous work has suggested that genetic, intrauterine, and environmental factors all contribute to the regulation of bone mass, but the ways in which they interact with each other to do so remain poorly understood. In this study, we investigated the relationship between peak bone mass and polymorphisms o

Efficient crystal plasticity simulations of microstructure evolution

One of the common tools for studying the deformation behavior of the microstructure in polycrystalline materials is crystal plasticity models. These are used to describe texture evolution and hardening due to crystallographic slip. A drawback when using crystal plasticity models is that the calculation of the slip requires solving a set of stiff differential equations for each grain in the microst

Plant Major Intrinsic Proteins - natural variation and evolution

Popular Abstract in Swedish Livets minsta beståndsdel, cellen, omges av ett membran som avgränsar den från omvärlden. För att hålla den inre miljön kontrollerad måste cellen kunna styra transporten av olika ämnen över membranet, vilket görs med hjälp av olika proteiner. Dessa proteiner kan antingen vara energikrävande pumpar och transportörer som aktivt förflyttar substanser över membranet, eller Major Intrinsic Proteins (MIPs, also called Aquaporins, AQPs) are channel forming membrane proteins. Although initially functionally characterized and named after their water channeling property in human red blood cells, it has become increasingly evident that MIPs are present in all types of organisms and transport a variety of small, uncharged molecules besides water. MIPs have a highly conserve

On the use of non-linear transformations for the evaluation of anisotropic rotationally symmetric directional integrals. Application to the stress analysis in fibred soft tissues

Microsphere-based constitutive models are a helpful tool in the modelling of materials with a microstructure composed of contributing elements directionally arranged. This is the case, for instance, for fibred soft tissues. In these models, the macroscopic mechanical behaviour is obtained from the integration of the micro-structural contribution of each component (e.g. each fibre) over the surface

Gender differences and determinants of aerobic fitness in children aged 8-11 years.

Previous studies of gender differences in maximum oxygen uptake have come to different conclusions. Limited data exists where the determinants of maximum oxygen uptake have been evaluated in a comprehensive manner. Thus, we examined 248 children (140 boys and 108 girls), aged 7.9-11.1 years. Body composition was determined by dual-energy X-ray absorptiometry, measured variables were total body fat

Cancer incidence among Swedish pulp and paper mill workers: a cohort study of sulphate and sulphite mills

Associations between various malignancies and work in the pulp and paper industry have been reported but mostly in analyses of mortality rather than incidence. We aimed to study cancer incidence by main mill pulping process, department and gender in a Swedish cohort of pulp and paper mill workers. The cohort (18,113 males and 2,292 females, enrolled from 1939 to 1999 with > 1 year of employment) w