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Preterm birth and psychiatric medication prescription in young adulthood: a Swedish national cohort study.

BACKGROUND: Recent studies suggest an increased risk of adverse mental health outcomes among young adults who were born preterm. These studies have been based mainly on hospital data, thus missing large numbers of mental health problems that do not require inpatient treatment. We used national outpatient and inpatient pharmacy data to evaluate whether individuals who were born preterm were more li

Voice Imitation : A Phonetic Study of Perceptual Illusions and Acoustic Success

Popular Abstract in Swedish I denna avhandling presenteras olika studier om röstimitation. Det unika i den individuella rösten och om det är möjligt att förändra sin röst så att man blir till förväxling lik någon annan vad gäller rösten och talet diskuteras. Syftet med studierna var i första hand att ta reda på hur och i vilken omfattning en imitatör förändrar sin egen röst och sitt tal för att blThis thesis is about voice imitations, more specifically impersonation. Questions are raised about the uniqueness of a person’s voice and speech behaviour and if it is possible to get close to another speaker’s voice and speech. Four main research questions are investigated in different studies. The studies focus mainly on how close the imitation is to the target speaker, and addresses to a lesser

Att förhandla litterärt värde – Sami Said och Väldigt sällan fin

This article aims to highlight how literary value is constructed today: how it is created and negotiated. It seeks to develop a perspective that considers the manifold and complex value­negotiation process. In accordance with Barbara Herrnstein Smith, the article argues that literary value is generated by a constant and continuous series of negotiations between production and sale: the institution

Concentration variability of potent allergens of p-tert-Butylphenol-formaldehyde resin (PTBP-FR) in patch test preparations and commercially available PTBP-FR.

Background: p-tert-Butylphenol-formaldehyde resin (PTBP-FR) is a common component of glues used in the manufacturing of many plastic, electronic, rubber, wood, and leather products. Two main allergens of PTBP-FR have been described. Objectives: The objective of this study is to determine the concentrations of the two main allergens of PTBP-FR in diagnostic patch testing preparations and PTBP-FR av

The foot in perspective.

The diabetic foot constitutes a tremendous challenge for patients, caregivers and the health care system. The International Consensus Document of 1999 was a milestone in the recognition of the importance and consequences of the diabetic foot. Since then, many original papers have been published in this area.Large cohort studies have given us a deeper understanding regarding factors related to the

Metabolic Engineering of Xylose-Utilising Saccharomyces cerevisiae Strains. A Closer Look at Recombinant Strains Based on the Xylose Reductase-Xylitol Dehydrogenase Pathway.

Saccharomyces cerevisiae produces ethanol efficiently from the hexose sugars in lignocellulose hydrolysates, but it can not utilise pentose sugars such as xylose and arabinose. Stable xylose-utilising S. cerevisiae strains obtained by integration of the Pichia stipitis genes encoding xylose reductase (XR), xylitol dehydrogenase (XDH) and xylulokinase, exhibit low ethanol yields when utilising xylo

Gene-Viral Cancer Therapy Using Dual-Regulated Oncolytic Adenovirus with Antiangiogenesis Gene for Increased Efficacy.

Conditionally replicative adenovirus (CRAD) represents a promising approach for cancer therapy. Several CRADs controlled by the human telomerase reverse transcriptase promoter have been developed. However, because of their replicative capacity, the importance of cancer specificity for CRADs needs to be further emphasized. In this study, we have developed a novel dual-regulated CRAD, CNHK500-mE, wh

Meeting Diversities in Maritime Education, a blend from World Maritime University

To address a diversified student complement in academic studies is becoming more and more frequent in maritime education and training. Diversity challenges are also the reality onboard ships that muster a multicultural crew complement. This thesis aims at creating awareness on dilemmas and challenges that students and faculty meet when working in a multicultural environment. In order not to have

IGF-1 protects against diabetic features in an in vivo model of Huntington's disease.

Huntington's disease (HD) is the most prevalent polyglutamine expansion disorder. HD is caused by an expansion of CAG triplet in the huntingtin (HTT) gene, associated with striatal and cortical neuronal loss. Central and peripheral metabolic abnormalities and altered insulin-like growth factor-1 (IGF-1) levels have been described in HD. Thus, we hypothesized that restoration of IGF-1-mediated sign

Making Swedish Environmental Geodata INSPIRE Conformant: : A Harmonization Case Study

The European project Nature-SDIplus has developed data and metadata specifications for three INSPIRE Annex III themes: Habitat and Biotopes, Bio-geographical regions and Species distributions. These serves as a foundation for the thematic groups developing the corresponding INSPIRE specifications. The aim of this study is to test a data harmonization approach to make Swedish environmental geodata

Which Entitlements and for Whom? The Convention on the Rights of Persons with Disabilities and its Ideological Antecedents

The Convention on the Rights of Persons with Disabilities (CRPD), adopted by the UN in 2006, represents the coming of age of a human rights approach to disability. In doing so, it provides answers to the questions what ‘disability’ is, who ‘persons with disabilities’ are and what entitlements are legitimate and relevant in relation to ‘disability’. Partly, these answers flow from the heritage of i

A History of the Future: Concepts for telling the story of online PR

The internet has had an impact on public relations that goes well beyond significant adjustments in practice made in response to technological change. Mirroring the emergence of ”Web 2.0” platforms, the discipline is increasingly articulating its purpose and culture through discourse associated with social media. Concepts such as transparency, authenticity, conversation and engagement can be inext

Molecular regulation of hematopoietic stem cells

Hematopoietic stem cells (HSCs) are ultimately responsible for the all mature blood cell production. They can primarily be found in the bone marrow (BM) at a low frequency (~0.02%). Unlike other blood cells, HSCs have a high degree of self-renewal capacity, the process where upon cell division, at least one daughter cell has the same properties as the stem cell it was generated from. In addition,

Selection and design in antibody phage display

The immune system is an important part of the physiology of higher organisms. In the immune system antibodies play a key role in neutralizing and clearing potentially lethal threats from the environment. The importance of antibodies in the immune system has made them come to the attention as a tool in chemistry and medicine. This thesis, which is based on four original papers, deal with antibody d

Change and Legitimation : Social Democratic Governments and Higher Education Policies in Sweden and Germany

Popular Abstract in Swedish Denna avhandling belyser reformer och åtgärder inom högskolesektorn (policies of higher education) som genomfördes av socialdemokratiska regeringar i Sverige och Tyskland, här speciellt i Nordrhein-Westfalen, från mitten av 1960-talet till och med år 2000. Utgångspunkten för avhandlingen var den omfattande litteraturen om förändringar inom europeiska högskolesystem. Det

Electronic structure of [100]-oriented free-standing InAs and InP nanowires with square and rectangular cross sections

We report on a theoretical study of the electronic structure of free-standing InAs and InP nanowires grown along the [100] crystallographic direction, based on an atomistic tight-binding approach. The band structure and wave functions for nanowires with both square (nanowires) and rectangular (nanobelts) cross sections are calculated. A comparison is made between the calculations for InAs, InP, an

Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice

It is not known whether GIP receptor and GLP-1 receptor knockout (KO) mice have perturbations in glucagon secretion or insulin clearance, and studies on impact on fasting glycemia have previously been inconsistent in these mice. We therefore studied glucagon secretion after oral whey protein (60 mg) and intravenous arginine (6.25 mg), insulin clearance after intravenous glucose (0.35 g/kg) and fas

Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute

Hemoglobin (Hb)-based oxygen carriers (HBOC) are modified extracellular proteins, designed to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results have generally been disappointing due to adverse side effects, in part linked to the intrinsic oxidative toxicity of Hb. Previously a redox-active tyrosine residue was engineered into the Hb β subunit (βF41Y) to fac

Familial aggregation and heterogeneity of non-Hodgkin lymphoma in population-based samples

The importance of genetic factors in the etiology of non-Hodgkin lymphoma (NHL) is suggested by case-control and cohort studies. Most previous studies have been too small to estimate accurately risks of specific categories of lymphoproliferative malignancies in relatives of NHL cases or to quantify the contribution of NHL case characteristics to familial risk. We have overcome sample size limitati