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Purpose: In one form of human autosomal recessive retinitis pigmentosa and in retinal degeneration (rd1) mouse, mutation occurs in the genes encoding ß subunit of rod photoreceptor cGMP phosphodiesterase. Therefore, rd1 mutant mouse is an appropriate model for human inherited retinal degeneration studies. Retinal explants are successfully cultured in serum free chemically defined R16 medium to eva

Investor-State Dispute Settlement (ISDS) is a mechanism that allows foreign investors to sue host States in private international tribunals for alleged breaches of investment protection standards. This mechanism, and international investment law in general, frequently excludes Indigenous Peoples, even when foreign investment projects directly impact them and violate their rights to land and self-d

Due to higher demands on the electrical systems in the aviation industry, the generation and distribution of electrical power, in aircrafts, needs to be researched and developed further. Key requirements include increased power capacity to meet future demands, a transition from AC to DC supply and an increased voltage level. For power generation, a generator is coupled to the jet turbine which mus

Relating to the ongoing discussion surrounding criticism and support for ESG scores, the purpose of this paper anchors itself in providing comprehensive, empirical evidence regarding the responsiveness of ESG scores to firm actions. The different strategic choices of multinational firms, resulting from political and stakeholder pressure, were to either fully withdraw, suspend or continue operation

This dissertation deals with the conflict between the World Alliance of Reformed Churches (WARC) - the worldwide Reformed movement - and the Dutch Reformed Church in South Africa (DRC) regarding the latter's support for and theological legitimizing of apartheid. One of the strongest measures possible was taken when the issue in 1982 was declared a Status Confessionis and the Dutch Reformed Church

Open Source projects are collaborative processes that generate value for users but generally disallow actors to generate revenue directly from the product that is developed. Nonetheless, many companies are involved in Open Source projects. Therefore it is of interest to study what kind of mechanisms are involved in how companies capture value from Open Source project involvement, and also what kin

Cognitively-normal people with evidence of β-amyloid (Aβ) pathology and subtle cognitive dysfunction are believed to be at high risk for progression to mild cognitive impairment due to Alzheimer's disease (AD). Clinical trials in later stages of AD typically include a coprimary endpoint to demonstrate efficacy on both cognitive and functional assessments. Recent trials focus on cognitively-normal

Optical DNA mapping (ODM) is based on fluorescent labeling, stretching and imaging of single DNA molecules to obtain sequence-specific fluorescence profiles, DNA barcodes. These barcodes can be mapped to theoretical counterparts obtained from DNA reference sequences, which in turn allow for DNA identification in complex samples and for detecting structural changes in individual DNA molecules. Ther