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Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington's disease

Accumulating evidence suggests altered energy metabolism as a key feature in Huntington's disease (HD) pathology. Hyper-catabolism, including weight loss and muscle atrophy, is seen in HD patients and HD mouse models. Metabolic hormones are key players, not only in energy metabolism, but also in neurodegenerative processes. Ghrelin, a gut peptide-hormone, plays an important role in regulating ener

Formation of uranium-thorium-rich bitumen nodules in the Lockne impact structure, Sweden : A mechanism for carbon concentration at impact sites

The Ordovician Lockne impact structure is located in central Sweden. The target lithology consisted of limestone and black unconsolidated shale overlaying a Precambrian crystalline basement. The Precambrian basement is uranium-rich, and the black shale is both uranium- and organic-rich. This circumstance makes Lockne a good candidate for testing the occurrence of U-Th-rich bitumen nodules in an im

Neuroarchitecture of the dung beetle central complex

Despite their tiny brains, insects show impressive abilities when navigating over short distances during path integration or during migration over thousands of kilometers across entire continents. Celestial compass cues often play an important role as references during navigation. In contrast to many other insects, South African dung beetles rely exclusively on celestial cues for visual reference

The middle ear immune defense changes with age

Otitis media is a common disease in childhood. In adults, the disease is relatively rare, but more frequently associated with complications. Possible reasons for this discrepancy are age-related differences in pathogen exposure, anatomy of the Eustachian tube and immune system. The objective of this study was to analyze the relationship between age and the mucosal immune system in the middle ear.

Correcting for selective participation in cohort studies using auxiliary register data without identification of non-participants

Aims: Selective participation may hamper the validity of population-based cohort studies. The resulting bias can be alleviated by linking auxiliary register data to both the participants and the non-participants of the study, estimating propensity scores for participation and correcting for participation based on these. However, registry holders may not be allowed to disclose sensitive data on (in

Cultivating a sustainable society : attempts to change contemporary Sweden by urban gardening and theatre

In this presentation, we discuss how projects use theatre and urban gardening as tools to handle and promote cultural diversity in Sweden. Our presentation build on data collected during the last decade in Malmö, a city characterised by immigration, super-diversity and a post-industrial economy. The projects we have studied are often short term and dependent on uncertain, external funding. The tar