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The adipose organ, including white and brown adipose tissues, is an important player in systemic energy homeostasis, storing excess energy in form of lipids while releasing energy upon various energy demands. Recent studies have demonstrated that white and brown adipocytes also function as endocrine cells and regulate systemic metabolism by secreting factors that act locally and systemically. Howe

Atrial natriuretic peptide (ANP) represents an attractive therapeutic target in hypertension and heart failure. The biologically active form of ANP is produced by the cardiac serine protease corin, and modulation of its activity might therefore represent a novel approach for ANP augmentation. MicroRNAs (miRNAs) are pervasive regulators of gene expression, but their potential role in regulating cor

In the latest World Tourism Barometer, UNWTO (2020) predicts that global tourism could decline by up to 80% this year. While many tourism-dependent economies in Europe are currently suffering from under-tourism, the heated debate between tourism developers and local stakeholders about adverse impacts of over-tourism is likely to reignite even stronger once the inrush of tourists returns. As a resu

In this study we describe combustion simulations of a single sector and a fully annular generic multi-burner aero-engine combustor. The objectives are to facilitate the understanding of the flow, mixing and combustion processes to help improve the combustor design and the design process, as well as to show that it is now feasible to perform high-fidelity reacting flow simulations of full annular g

Denna avhandling omfattar en komparativ studie av systemen för domstolsprövning av förvaltningsbeslut enligt svensk, dansk och österrikisk rätt. Framställningen omfattar en rättslig analys av de regler och principer som styr dels när en domstolsprövning av förvaltningsbeslut kan komma till stånd (vilka sakprövningsförutsättningar som gäller), dels vad en sådan prövning omfattar och kan leda till (This thesis contains a comparative study of the systems of judicial review of administrative decisions in Swedish, Danish, and Austrian law. The main aim of the study is to explore how the three legal systems balance certain interests and functions that are related to the phenomenon of judicial review of administrative acts: on the one hand, the principle of effective judicial protection as well a

The latitudinal diversity gradient (LDG) is one of Earth’s most iconic biodiversity patterns and still one of the most debated. Explanations for the LDG are often categorized into three broad pathways in which the diversity gradient is created by (1) differential diversification rates, (2) differential carrying capacities (ecological limits), or (3) differential time to accumulate species across l

The statistical resources at hand for segregation research are usually almost exclusively confined to annual or decennial records where the only available spatial information is the individual’s place of residence. This coarse temporal periodicity and spatial resolution provides a very limited account of people’s diurnal lives. Incorporating mobility and temporal dimensions in segregation analysis

Parvalbumin- (PV-) containing basket cells constitute perisomatic GABAergic inhibitory interneurons innervating principal cells at perisomatic area, a strategic location that allows them to efficiently control the output and synchronize oscillatory activity at gamma frequency (30–90 Hz) oscillations. This oscillatory activity can convert into higher frequency epileptiform activity, and therefore c