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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

The cellular hallmarks of Parkinson's disease (PD) are the loss of nigral dopaminergic neurons and the formation of α-synuclein-enriched Lewy bodies and Lewy neurites in the remaining neurons. Based on the topographic distribution of Lewy bodies established after autopsy of brains from PD patients, Braak and coworkers hypothesized that Lewy pathology primes in the enteric nervous system and spread

Nurses’ experiences of encountering undocumented migrants in Swedish emergency healthcare

Purpose – The purpose of this paper is to investigate how nurses’ working in emergency health care in Sweden experience their encounter with undocumented migrants. Design/methodology/approach – A total of 16 qualitative interviews were conducted and analyzed using a phenomenographic approach, aiming at describing various ways in which nurses experienced undocumentedness. Findings – The process of

The Refined Structure of dUTPase from Escherichia coli

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase, E.C. 3.6.1.23) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate and is involved in nucleotide metabolism and DNA synthesis. A crystal of the recombinant E. coli enzyme, precipitated from polyethylene glycol mixtures in the presence of succinate at pH 4.2, was used to collect synchrotron diffraction data to 1.9 Å resolution, in sp

Influence of the characteristic curve on the clinical image quality of lumbar spine and chest radiographs.

The "European Guidelines on Quality Criteria for Diagnostic Radiographic Images" do not address the choice of the film characteristic (H&D) curve, which is an important parameter for the description of a radiographic screen–film system. The image contrast of clinical lumbar spine and chest radiographs was altered by digital image processing techniques, simulating images with different H&D

A generic model for C-11 labelled radiopharmaceuticals for imaging receptors in the human brain

A large number of rachopharmaceuticals labelled with C-11 (half-time 0.340 h) are being developed for positron emission tomographic studies of different types of receptor in the human brain. For most of these agents, the available biokinetic data are insufficient to construct realistic compound-specific biokinetic models for calculating the internal radiation dose delivered to persons undergoing i

Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors

Studies from our and other laboratories have over the last 2 years implicated the existence of multipotent progenitors (MPPs) with combined granulocyte-macrophage, B cell, and T cell potential, but little or no megakaryocyte-erythroid (MkE) potential in the adult bone marrow Lineage (-)SCA-1 +KIT+ (LSK) compartment of multipotent stem and progenitor cells. The evidence for the existence of LSKCD34

Meta-managing: A Study on How Superiors and Subordinates Manage Their Relationship in Everyday Work

In virtually every organization we find formally appointed managers, but nevertheless we tend to condemn the idea of formal hierarchy and celebrate alternative modes of governance that better respect the discretion of employees. This tension, that seemingly surrounds the vertical dimension of contemporary organizations, forms the backdrop of this study which examines how superiors and subordinates

Rebecca West’s Harriet Hume: Psychoanalysis and the Discourse of Sovereignty

Building on Michel Foucault’s (1976) argument that a grand narrative of sovereignty characterised the idea of government and permeated entire systems of thought in the twentieth century, this paper asks whether Freudian psychoanalysis is also embedded within the same meta-discourse. Drawing on psychoanalytic accounts of Rebecca West’s work (Varney, 2000; Bonikowski, 2005) which tend to focus on We

Hand Veins Feature Extraction using DT-CNNs

As the identification process is based on the unique patterns of the users, biometrics technologies are expected to provide highly secure authentication systems. The existing systems using fingerprints or retina patterns are, however, very vulnerable. One’s fingerprints are accessible as soon as the person touches a surface, while a high resolution camera easily captures the retina pattern. Thus,

Studies on chondroadherin-an extracellular matrix leucine-rich repeat protein

Popular Abstract in Swedish Populärvetenskaplig sammanfattning: (Popularized summary in swedish) I den här avhandlingen har vi studerat bindväven i brosk. Bindväv är ett samlingsnamn för de stödjevävnader som ger form och struktur åt brosk, ben, senor, hud etc. Bindväven skyddar även inre organ från yttre påverkan. Det är bindväven som ger brosket dess speciella egenskaper och som gör att brosketThis thesis describes chondroadherin, one of the leucine-rich repeat proteins in the extracellular matrix (ECM) of cartilage. Chondroadherin defines a subgroup of its own by not having an N-terminal extension, having a different cysteine pattern and by being devoid of carbohydrate substitutions. Here we show that chondroadherin also have a different exon-intron organization and chromosomal localiz

Interdisciplinarity, group responsibility and conflict as resources for learning

In the autumn of 2011, the course “The City: Boundary Transgressions and Visual Expressions” was given for the first time. Formally placed at the Division of Art History and Visual Studies, the course is a collaboration with the Division of Social Anthropology and is directed towards students from a range of disciplines within the fields of the humanities and social sciences. The course includes