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Calcitonin gene-related peptide (CGRP) research was initiated by Poyner et al.,(1) who found that the calcitonin gene encodes the 37-amino acid neuropeptide CGRP in neuronal tissue. Within months, the Lund group produced antibodies toward α-CGRP and developed sensitive methods to study the role of this peptide in the cranial circulation. Intracranial vessels and the trigeminal ganglion harbor this
Dinoflagellates are haploid eukaryotic microalgae in which rapid proliferation causes dense blooms, with harmful health and economic effects to humans. The proliferation mode is mainly asexual, as the sexual cycle is believed to be rare and restricted to stressful environmental conditions. However, sexuality is key to explaining the recurrence of many dinoflagellate blooms because in many species
BackgroundFertility is impaired in many survivors of childhood cancer following treatment. Preservation of fertility after cancer has become a central survivorship concern. Nevertheless, several doctors, patients, and families do not discuss fertility and recommendations for fertility preservation in pediatrics are still lacking. Recommendations based on scientific evidence are needed and before t
Various factors influencing affinity partitioning in aqueous polymer two-phase systems are studied by model calculations using a self-consistent mean-field lattice theory. The latter is an extension of the theory of Scheutjens and Fleer, adapted to take affinity ligand binding into account. The dependence of partition coefficients on ligand concentration is studied for different binding strengths,
Extremely thinned layers and possible folding make the dating of the deepest sections of ice cores especially challenging. Cosmogenic radionuclides have the potential to provide independent age estimates. The 36Cl/10Be ratio is largely independent of production rate changes that affect individual radionuclides and has an effective half-life of 384 kyr, making it an ideal tool for dating the new 1.
Travel guidebooks are both travel information channels and objects of consumption. In contemporary tourism, Information and Communication Technologies (ICT) make information abundant and mostly free of charge. Therefore, as tourists still buy them, there must be something that makes guidebooks a valuable object. This research aims at understanding the value of travel guidebooks in the digital age.
Virusinfektioner har utan tvekan blivit det största hälsoproblemet i världen. I skrivande stund når antalet COVID-19 infektioner i världen upp emot 151 800 000 vilket gör att behovet av vacciner och antivirala läkemedel är viktigare nu än någonsin tidigare. Influensa A är ytligare ett virus som orsakar överdödlighet, trotts att många klarar sig lindrigt vid infektion. För att kunna förhindra ellerWith viral infections becoming an ever-increasing health problem in the world, the study of viral proteins is a cornerstone for understanding and preventing future pandemics. The following work shows the purification and structural characterization of the Influenza A M2 proton channel through solid-state NMR (ssNMR). Despite previously published structures of the M2 proton channel, the method of p
Creativity is a principal force of cognitive and communicational genesis that causes alteration of established rules and concepts (Heine/Kuteva 2007) and transgression of cultural borders (Lotman 1990). Artistic activity is normally taken for granted as creative, despite the fact that much artistic intention, is not necessarily aspiring to make any radical change of the circumstances in which it i
Background: Patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HCT) often face complex and evolving needs throughout recovery. Person-centred nursing (PCN) is essential in this context yet remains underexplored in specialised care settings. In Sweden, the Assessment of Rehabilitation Needs Checklist (ARNC) is commonly used in cancer care, but its role in supporting perso
The removal and degradation of refractory antibiotics in saline water by electrochemical and photo-electrochemical catalysis has emerged as a worldwide research hotspot. Aiming to improve degradation performance, most of the concerned studies focus on new sophisticated materials and modification methods on the single working electrode (anode or cathode). But the synergistic effects between anode a
We present a multidisciplinary description of the Upper Ordovician carbonate mounds which are found throughout the central Baltic Sea and which were studied in detail on the island of Gotland. These mounds were the subject of intense exploration between 1974 and 1992 and a total of 323 shallow wells were completed in more than 100 mounds on Gotland. Many of these were put into production and a tot
