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Background: Cerebrospinal fluid (CSF) biomarkers have gained increasing importance in the diagnostic work-up of Alzheimer's disease (AD). The core CSF biomarkers related to AD pathology (Aβ42, t-tau and p-tau) are currently used in CSF diagnostics, while candidate markers of amyloid metabolism (Aβ38, Aβ40, sAPPα, sAPPβ), synaptic loss (neurogranin), neuroinflammation (YKL-40), neuronal damage (VIL
Migratory songbirds are guided by an endogenous programme during their first migration, encoding timing of migration, distance and direction. To successfully perform migration, birds have evolved phenotypic adaptations for flight, fuelling and navigation. Migratory distance in different species of birds is encoded as a period of expressed migratory restlessness, for which the length is correlated
During protein crystallization and purification, proteins are commonly found in concentrated salt solutions. The exact interplay of the hydration shell, the salt ions, and protein-protein interactions under these conditions is far from being understood on a fundamental level, despite the obvious practical relevance. We have studied a model globular protein (bovine serum albumin, BSA) in concentrat
The novel wrought nickel-based superalloy, AD 730™, is a good candidate material for turbine disc applications at high temperatures beyond 650 °C. The present study focuses on the machining performance of this newly developed alloy under high-speed turning conditions with advanced PCBN tools. Meanwhile, the machined surface integrity as influenced by cutting speed and feed rate was also investigat
Exploring the patterns of genetic structure in the context of geographical andphenotypic variation is important to understand the evolutionary processesinvolved in speciation. We investigated population and subspecies differentiationin the Common Ringed Plover Charadrius hiaticula, a high latitude wader thatbreeds in arctic and temperate zones from northeast Canada across Eurasia tothe Russian Far
Purpose – The purpose of this paper is to investigate whether and how knowledge hoarding, functions as antecedent and consequent of work related negative acts, as a measure of bullying. The authors investigate the relation as mediated by trust and justice. Design/methodology/approach – Data stem from a longitudinal study in which questionnaire responses were collected twice from 1,650 employees in
