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Papillary renal cell carcinoma-derived chemerin, IL-8, and CXCL16 promote monocyte recruitment and differentiation into foam-cell macrophages

Papillary renal cell carcinoma (pRCC) is the second most common type of renal cell carcinoma. The only curative treatment available for pRCC is radical surgery. If the disease becomes widespread, neither chemo- nor radiotherapy will have therapeutic effect, hence further research on pRCC is of utmost importance. Histologically, pRCC is characterized by a papillary growth pattern with focal aggrega

The transcription factor ABI4 is a regulator of mitochondrial retrograde expression of ALTERNATIVE OXIDASE1a

Plant cells integrate signals from external sources and from organelles to regulate gene expression, referred to as anterograde and retrograde signaling, respectively. Functional characterization of the promoter of ALTERNATIVE OXIDASE1a (AOX1a) from Arabidopsis (Arabidopsis thaliana), a marker for mitochondrial retrograde response, was carried out by testing the ability of the AOX1a promoter to dr

Estimating glomerular filtration rate (GFR) in children. The average between a cystatin C- and a creatinine-based equation improves estimation of GFR in both children and adults and enables diagnosing Shrunken Pore Syndrome

Estimating glomerular filtration rate (GFR) in adults by using the average of values obtained by a cystatin C- (eGFRcystatin C) and a creatinine-based (eGFRcreatinine) equation shows at least the same diagnostic performance as GFR estimates obtained by equations using only one of these analytes or by complex equations using both analytes. Comparison of eGFRcystatin C and eGFRcreatinine plays a piv

Panel 4 : Report of the Microbiology Panel

Objective: To perform a comprehensive review of the literature from July 2011 until June 2015 on the virology and bacteriology of otitis media in children. Data Sources: PubMed database of the National Library of Medicine. Review Methods: Two subpanels comprising experts in the virology and bacteriology of otitis media were created. Each panel reviewed the relevant literature in the fields of viro

A method for assessment of exposure to rubber glove allergens

Background: Use of disposable protective gloves in health care is necessary both to protect patients and personnel. However, the use might also be responsible for skin disease among persons wearing the gloves. Dermatitis may be caused by additives in the gloves, either from manufacturing of the glove material or components in coatings applied after vulcanization. Objectives: We wanted to analyse t

The pedagogical dimension of internationalisation? : A challenging quality issue in higher education for the twenty-first century

What are the pedagogical impacts of internationalisation on the development of higher education in Europe? How can we proceed in this process and take a pedagogical stance on the issue? This theoretical article is partly based on a series of empirical studies, conducted by the author, investigating students' and teachers' experiences and understanding of an internationalised educational context in

Quality enhancement through the introduction of SoTL : From tips and tricks to a scholarly approach

The aim of courses conducted by centers for educational development is to enhance and sustain quality in teaching and learning in higher education. Research suggests that taking a scholarly approach to teaching and learning results in higher quality teaching, which, in turn, promotes student learning (Trigwell & Shale, 2004). Moreover, a scholarly approach to teaching and learning helps sustai

The World Health Organization international collaborative study for islet cell antibodies

Aims/hypothesis. Islet cell autoantibodies are a specific marker for Type 1 (insulin-dependent) diabetes mellitus. Standardisation of islet cell antibodies and the uniform reporting in International units is critical to research and the development of assays for islet cell autoantibodies as diagnostics. Methods. The suitability of a candidate serum to serve as the international standard for islet

Knowledge hoarding : antecedent or consequent of negative acts? The mediating role of trust and justice

Purpose – The purpose of this paper is to investigate whether and how knowledge hoarding, functions as antecedent and consequent of work related negative acts, as a measure of bullying. The authors investigate the relation as mediated by trust and justice. Design/methodology/approach – Data stem from a longitudinal study in which questionnaire responses were collected twice from 1,650 employees in

Improving Touschek lifetime in ultralow-emittance lattices through systematic application of successive closed vertical dispersion bumps

In present ultralow-emittance storage ring designs the emittance coupling required for the production of vertically diffraction-limited synchrotron radiation in the hard x-ray regime is achieved and in many cases surpassed by a correction of the orbit and the linear optics alone. However, operating with a vertical emittance lower than required is disadvantageous, since it decreases Touschek lifeti

Is salivary gland ultrasonography a useful tool in Sjögren's syndrome? A systematic review

Objective. Ultrasonography (US) is a sensitive tool in the diagnosis of major salivary gland abnormalities in primary Sjögren's syndrome (pSS). The aim of this systematic review was to assess the metric properties of this technique. Methods. PUBMED and EMBASE databases were searched. All publications between January 1988 and January 2013 were considered. Data were extracted from the articles meeti