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The Role of Surgical Axillary Staging Prior to Immediate Breast Reconstruction in the Era of De-Escalation of Axillary Management in Early Breast Cancer

Postmastectomy radiotherapy (PMRT) following immediate breast reconstruction (IBR) is associated with postoperative complications. Although the incidence of node-positive breast cancer is declining, a separate sentinel lymph node biopsy (SLNB) is still performed before mastectomy when IBR is planned, in order to evaluate nodal status and the need for PMRT. This study assessed the impact of staged

A political ecology of aviation and development : an analysis of relations of power and justice in the (de)construction of Nepal's Second International Airport

In this article, we investigate socio-ecological conflicts surrounding the proposed Second International Airport project near Nijgadh, a town in the southern Terai region of Nepal. Praised by the Nepali government as a gamechanger for Nepal's economy, it has come under scrutiny by environmental activists after plans emerged for extensive clearing of the densely forested project site. While public

Moral Elites and the De-Paradoxification of Danish Social Policy Between Civil Society and State (1849–2022)

The article argues that in Denmark during the past 150 years, moral elites have been central in settling paradoxes within social policy by developing ‘classifications’ of citizens and sectors: who are deserving of help and what sector (public or third) should provide care. Contrary to widely held beliefs, historically, there is no logical or practical connection between ‘more deserving’ and ‘state

Simultaneous 3D T1 and B1+ mapping at 7T using MPRAGE with multiple volumes and driven equilibrium (DE)

MP2RAGE has become popular for T1 mapping at 7T. Accuracy is yet improved by using a separately acquired flip angle map when creating the protocol-specific lookup table. Here, two additional volumes acquired at differing flip angles are added to an MP2RAGE sequence to obtain two separate states of driven equilibriums, effectively forming a dual flip angle protocol within the cycle. By estimating t

De novo active sites for resurrected Precambrian enzymes

Protein engineering studies often suggest the emergence of completely new enzyme functionalities to be highly improbable. However, enzymes likely catalysed many different reactions already in the last universal common ancestor. Mechanisms for the emergence of completely new active sites must therefore either plausibly exist or at least have existed at the primordial protein stage. Here, we use res