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Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs re
MP2RAGE has become popular for T1 mapping at 7T. Accuracy is yet improved by using a separately acquired flip angle map when creating the protocol-specific lookup table. Here, two additional volumes acquired at differing flip angles are added to an MP2RAGE sequence to obtain two separate states of driven equilibriums, effectively forming a dual flip angle protocol within the cycle. By estimating t
Shot over an eight-year period, Outcry and Whisper presents itself as a political manifesto for the resistance of women, be they workers, artists, intellectuals or militants, in Chinese and Hong Kong society. Their accounts shine a light on a ferocious battle for independence.
St. Bridget of Sweden was very much concerned about the decay and corruption of the Church. She had many revelations in which Christ and St. Mary appeared condemning abuses and bad practices. After St Bridget's death some of the revelations to and concerning popes were published by her Spanish confessor, Alfonso, former Bishop of Jaén. The present book gives an edition of the original Alfonsine co
Background: Actinomycetes of the genus Streptomyces are renowned for their highly developed and diverse specialized metaboliс pathways, and there is an extensive body of data on their specific and pleiotropic levels of regulation. Much less is known about routes leading to essential metabolites in this genus. In this work, we focused on elucidating the function of the highly conserved across Strep
Mandatory human rights and environmental due diligence (HREDD) policies seem to represent a pathbreaking shift from voluntary measures to binding rules for global supply chains. Yet these policies endorse a “smart-mix” of voluntary and mandatory measures, and risk over-reliance on questionable private-sector assurances. In this paper, we ask how businesses framed these private/voluntary efforts in
Violaxanthin deepoxidase (VDE) has been purified from spinach (Spinacia oleracea) leaves. The purification included differential sonication of thylakoid membranes, differential (NH4)2SO4 fractionation, gel filtration chromatography and finally either hydrophobic interaction chromatography or anion exchange chromatography. A total purification of more than 5000-fold compared to the original thylako
Abstract is not available
