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Sensor degradation poses a significant challenge in autonomous driving. During heavy rainfall, interference from raindrops can adversely affect the quality of LiDAR point clouds, resulting in, for instance, inaccurate point measurements. This, in turn, can potentially lead to safety concerns if autonomous driving systems are not weather-aware, i.e., if they are unable to discern such changes. In t

Protein transport across the cytoplasmic membrane of bacterial cells is mediated by either the general secretion (Sec) system or the twin-arginine translocase (Tat). The Tat machinery exports folded and cofactor-containing proteins from the cytoplasm to the periplasm by using the transmembrane proton motive force as a source of energy. The Tat apparatus apparently senses the folded state of its pr

Directed evolution has revolutionized protein engineering. Still, enzyme optimization by random library screening remains sluggish, in large part due to futile probing of mutations that are catalytically neutral and/or impair stability and folding. FuncLib is a novel approach which uses phylogenetic analysis and Rosetta design to rank enzyme variants with multiple mutations, on the basis of predic

This investigation deals with the debate surrounding the controversial question of whether there exists a constitutive tradition at the Second Vatican Council (1962-1965). The investigation can broadly be divided into three sections. The first section provides both an analysis of the terminology relevant for understanding and a theological background. The background leads up the Council of Trent (

Emerging from the citizen movements of the early 2010s, New Municipalism merges the administrative capacity of municipal government with the organizational capacities of activists and social movements to build more equal, just and ecological local economies. In these contexts, Digital Municipal Currencies (DMCs) emerge as potent instruments of counter-hegemonic struggle, enabling cities to impleme

The rich Mayan weaving tradition in Guatemala has survived even though the indigenous population has been subject to centuries of hardship and oppression. After conducting a field study and scrutinising the commercialisation process of the traditional designs in five different producer cooperatives of which, for the purpose of this thesis, some are characterised as weaving cooperatives and others

Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate that FLT3 ITD, FLT3 N676K, and NRAS G12D accelerate KMT2A-MLLT3 leukemia onset. Further, also subclonal FLT3 N676K mutations accelerate

BACKGROUND: Bacterial surfaces are complex systems, constructed from membranes, peptidoglycan and, importantly, proteins. The proteins play crucial roles as critical regulators of how the bacterium interacts with and survive in its environment. A full catalog of the motifs in protein families and their relative conservation grade is a prerequisite to target the protein-protein interaction that bac