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Background: Circulating tumor cells (CTCs) carry independent prognostic information in patients with metastatic breast cancer (MBC) on different lines of therapy. Moreover, CTC clusters are suggested to add prognostic information to CTC enumeration alone but their significance is unknown in patients with newly diagnosed MBC. We aimed to evaluate whether longitudinal enumeration of circulating tumo

Objective: To analyze the outcomes of urgent/emergent endovascular aortic repair of patients with free/contained ruptured thoracoabdominal aortic aneurysms (rTAAA). Background: Endovascular repair of rTAAA has been scarcely described in emergent setting. Methods: An international multicenter retrospective observational study (ClinicalTrials.govID:NCT05956873) from January 2015 to January 2023 in 6

Background:The optimal treatment of displaced femoral neck fractures in patients 55 to 70 years old remains controversial. The aim of the present study was to assess the effect of closed reduction and internal fixation with cannulated screws (IF) compared with total hip arthroplasty (THA) on hip pain and function, with use of data for outcome measures, complications, and reoperations.Methods:This

Background: To identify subjects with rupture-prone atherosclerotic plaques before thrombotic events occur is an unmet clinical need. Thus, this proof-of-concept study aims to determine which rupture-prone plaque features can be detected using clinically available photon-counting computed tomography (PCCT). Methods: In this retrospective study, advanced atherosclerotic plaques (ex vivo, paraffin-e

Background: Substance use among older persons occurs with medical and psychiatric comorbidities. This study examined the associations of substance use disorder (SUD), psychiatric, and dual diagnoses with 12-month cumulative hospitalized days, hospital admission rate and number of days to first hospitalization.Methods: The cohort of 3,624 individuals (28.2% women) aged 50 years or older was assesse

Kyrkspirorna och tornen på Stockholms horisont blandar sig med radiosändningar som flyger ut över staden bredvid privatiserade våglängder, driver ner genom atmosfären och sjunker ner i det övergivna underjordiska telefonsystemet. Stockholm har byggnader som funnits där i århundraden, men är också full av den mest moderna och samtida arkitektur. Allt konkurrerar om sin plats i det kollektiva minnetThe towers of the Stockholm skyline twine with radio transmissions, flying out over the city, drifting down through the streets and sinking into the underground telephone system below. Stockholm has buildings that have been there for centuries, but is also full of modern and contemporary architectures, all jostling for their place in parallel collective memory. In taking the city up as a subject,

BACKGROUND: Participants' study satisfaction is important for both compliance with study protocols and retention, but research on parent study satisfaction is rare. This study sought to identify factors associated with parent study satisfaction in The Environmental Determinants of Diabetes in the Young (TEDDY) study, a longitudinal, multinational (US, Finland, Germany, Sweden) study of children at

The thesis presented here delves into why dwell time delays for commuter trains occur, with a specific focus on the impact of boarding and alighting passengers. The overarching aim is to develop knowledge of how time delays arise to identify and describe potential ways in which dwell time delays can be reduced. In addition to this, a secondary aim is to identify how dwell times can be studied on a

Popular Abstract in Swedish Studien behandlar den sydsvenske bonadsmålaren Johannes Nilssons måleri. Denne produktive målare levde och verkade i Breareds socken i södra Halland 1757­1827. En analys av hans bonader visar att han i många stycken frångick sina föregångares traditionella, imiterande framställning och begränsade motivkrets. Den övergripande frågan i avhandlingen är: varför målade JohanThe aim of this dissertation is to find relationships between folk art, an artist's personal life and influential factors originating in the context. Christmas wall hangings by the peasant painter Johannes Nilsson (1757­1827) are the focus of the study. The fact that he had a special approach to the painting tradition raises two questions: Why did he paint the way he did? How can his hangings be i

Background: Rat models of peritoneal dialysis (PD) are useful for studying the physiology of peritoneal transport and evaluating new osmotic agents. Intraperitoneal (IP) solute concentrations and their evolution over time are easy to measure, but IP volume (IPV) is not. Direct volumetric measurements are the "gold standard;' but they are expensive and do not allow for repetitive measurements in th

Popular Abstract in Swedish Avhandlingen består av tre uppsatser som behandlar empiriska tillämpningar av makroekonomiska teorier. Uppsatserna är fristående från varandra, men knyts samman genom att kointegrationsanalys används i de empiriska analyserna. Kointegrationsanalys är en statistisk metod som syftar till att hitta långsiktiga samband mellan olika variabler i ett empiriskt datamaterial. EfThis thesis focuses on empirical applications and tests of macroeconomic theories. It consists of three fairly distinct essays, bound together by the common theme of the use of cointegration analysis in the empirical macroeconomic analysis. The first chapter is an introductory chapter, while chapter two, three and four contain the three essays. The first essay, Wage Formation and the Relation bet

Background: Perinatal asphyxia is a major cause of mortality and morbidity. To date there are no reliable methods to detect which infants will develop brain damage after asphyxia insult. We investigated whether measurements of urine levels of S100B in asphyxiated full-term newborns maybe a useful tool for early detection of post-asphyxia brain damage. Methods: A prospective study of 38 infants wit

Popular Abstract in Swedish Detta är en avhandling om hur en del av vårt meningsskapande går till, sedd genom åtta studenters användning av sina kontextuella resurser. Den handlar om hur vi lyssnar till auditiva, visuella och upplevda röster, och hur vi talar med stöd av dessa röster när vi skapar och utvecklar vår egen röst. Detta kallar jag för rapporterat lyssnande, d.v.s. dessa yttranden visarThis thesis has two points of departure and four main purposes. The first point of departure concerns the narrow perspective of the listening skill in Swedish. The first purpose is to show the lack of attention to the listening skill in research and mother tongue education in the Swedish compulsory school. Educational documents from 1842 to 2000 about Swedish as a school subject are examined from

The levels of heavy metals in surface water and their potential origin (natural and anthropogenic) were respectively determined and analysed for the Obuasi mining area in Ghana. Using Hawth's tool an extension in ArcGIS 9.2 software, a total of 48 water sample points in Obuasi and its environs were randomly selected for study. The magnitude of As, Cu, Mn, Fe, Pb, Hg, Zn and Cd in surface water fro

Popular Abstract in Swedish Livet uppe på en pelare År 423 e.Kr. klättrade en man som närmade sig fyrtioårsåldern upp på en pelare, för att leva resten av sitt liv på dess topp; det skulle bli nästan fyrtio år till på knappt tjugo meters höjd. Han hette Symeon och skulle redan i sin samtid bli världsberömd för sin märkliga livsstil, som den första styliten, eller pelarhelgonet. I dagens krigsdrabThe fundamental question in this work concerns the ideal relation between asceticism and society in a 5th c. writing (C.E.), the Philotheos Historia (PH), written in elaborate Greek by the learned bishop of Cyrrhus, Theodoret. This collection of saints’ stories tells about the lives of a number of ascetics who lived in the Eastern part of the Roman Empire, many of them close to Antioch. As these n

Popular Abstract in Swedish Allt eftersom fler och fler organismers totala uppsättning gener, genomet, sekvenseras ökar fokus på att kartlägga de genprodukter, proteiner, som uttrycks. Att kunna studera de proteiner som uttrycks mer eller mindre vid olika tidpunkter eller cellulära tillstånd utgör en viktig del i sökandet efter kunskap om biologiska och medicinska processer. Studier av den totala The study of the protein complement of a genome is called proteomics. Proteomics can be defined as identification, quantification and characterization of a total set of proteins expressed at different time-points or under different cellular states to provide global information about biological processes. The study of membrane proteins is a challenging area in the development of proteomic research.

Objective: To explore whether magnetic resonance imaging (MRI) features suggestive of knee osteoarthritis (OA) are associated with presence of knee pain in possible early-stage OA development. Methods: We included 294 participants from the Osteoarthritis Initiative (mean ± SD age 50 ± 3 years; 50% women) with baseline Kellgren/Lawrence grade of 0 in both knees, all of whom had received knee MRIs a

In 2009, the Swedish government launched a nationwide dissemination and implementation project regarding substance abuse treatment, Knowledge to Practice (KTP), which was commissioned by the Swedish National Board of Health and Welfare (SoS). Aim: The study aimed to evaluate the effectiveness of a national project to disseminate and implement evidence-based assessment instruments and treatment met

Traditionally, automatic control techniques arose due to need for automation in mechanical systems. These techniques rely on robust mathematical modelling of physical systems with the goal to drive their behaviour to desired set-points. Decades of research have successfully automated, optimized, and ensured safety of a wide variety of mechanical systems. Recent advancement in digital technology ha

BACKGROUND AND OBJECTIVES: Human genetic studies support a key role of interleukin-6 (IL-6) in the pathogenesis of ischemic stroke. Still, there are only limited data from observational studies exploring circulating IL-6 levels as a risk factor for ischemic stroke. Here, we set out to perform a systematic review and meta-analysis of aggregate data on cohort studies to determine the magnitude and s