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Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease

Ever since its introduction 40 years ago l-3,4-dihydroxyphenylalanine (l-DOPA) therapy has retained its role as the leading standard medication for patients with Parkinson's disease. With time, however, the shortcomings of oral l-DOPA treatment have become apparent, particularly the motor fluctuations and troublesome dyskinetic side effects. These side effects, which are caused by the excessive sw

Svenska, språklig inriktning 1–40 poäng

Svenska, språklig inriktning 1–40 poäng Vårterminen 2026 Litteraturlista för SVEA42, Svenska med språkvetenskaplig inriktning – fortsättningskurs, 30 hp Fastställd av styrelsen för sektion 1 vid Språk- och litteraturcentrum den 13 november 2024. Delkurs 1: Texter, genrer och diskurser (5 hp) Obligatorisk litteratur Björkvall, Anders (2019). Den visuella texten: multimodal analys i praktiken. 2:a u

https://www.sol.lu.se/media/utbildning/dokument/kurser/SVEA42/20261/LITT_SVEA42_KLAR.pdf - 2026-05-07

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LUNDS UNIVERSITET Språk- och litteraturcentrum ÖVNINGSEXEMPLAR: INTRÄDESPROV/NIVÅTEST i Svenska som främmande språk, nivå 5, 6, 7, 8 Ifylles av student (med kulspetspenna) Namn Personnummer Ifylles av skrivvakt: 0 0 Skrivningen inlämnad: _ ______ _ Legitimation uppvisad: ja nej Skrivvaktens signatur: _______ _ Ifylles av läraren: Inga hjälpmedel! Resultat: __ /200 p. = ___ % Gram: Uppsats: __ _ Mo

https://www.sol.lu.se/fileadmin/user_upload/sol/aemnen/sektion1/OEvningstenta_intraedesprov_nivaatest_5_6_7_8.pdf - 2026-05-07

Teaching and learning regimes as an educational challenge and opportunity

Implicit assumptions, approaches, rules and practices in teaching i.e. teaching and learning regimes (TLRs) are produced and reproduced (cf. Trowler & Cooper 2002) in the closest teaching environment, traditionally within a discipline. However, multidisciplinary programs implies that teachers from different disciplines and with different taken for granted assumptions, approaches and rules are Implicit assumptions, approaches, rules and practices in teaching i.e. teaching and learning regimes (TLRs) are produced and reproduced (cf. Trowler & Cooper 2002) in the closest teaching environment, traditionally within a discipline. However, multidisciplinary programs implies that teachers from different disciplines and with different taken for granted assumptions, approaches and rules are

Energieffektivisering i småskaliga värmeanläggningar

On a commission of E.ON Värme Sverige AB an assistance tool has been developed to guide and systemize the energy survey process at the company's small scale heating plants. This has led to the development of Energistegen which with its information manual, "Manual how to perform an Energy Survey at Small Scale Plants", and its calculation tool, "Form for Energy Survey". This

Function of Innate Immune Cells in Breast Cancer

Tumor associated macrophages (TAMs) are key cells in creating an immunosuppressive tumor microenvironment (TME). In general, presence of TAMs is associated with worse outcome in cancer patients. Macrophages with anti-tumor effect can be found in the TME but are usually in minority. This thesis focuses on the role of innate immune cells, and especially macrophages, in breast cancer. In the first pr

Sugar consumption and cardiometabolic risk. With a focus on the urinary sucrose and fructose biomarkers.

Introduction: In contrast to the intake of sugar-sweetened beverages (SSBs), the evidence linking added sugar intake to the risk of cardiometabolic disease (primarily referring to cardiovascular disease and type 2 diabetes (T2D)) is contradictory. Aim: The aim of this thesis is to elucidate the role of added sugar intake in the risk for cardiometabolic diseases. To obtain further understanding of

Mechanistic and therapeutic studies in cardiac inflammation

Cardiovascular disease (CVD) is the leading cause of death globally. Inflammatory cardiomyopathies can be life-threatening, and the underlying mechanisms are not fully understood. This thesis aimed to investigate the underlying mechanisms driving the pathogenesis of myocarditis and septic cardiomyopathy, and to explore potential treatment strategies. In particular, we focused on the pro-inflammato

Quantifying the impact of Covid-19 on the energy consumption in the low-income housing in Greater London

Covid-19 has caused great challenges to the energy sector, particularly in residential buildings with low-income households. This study investigates the impact of the confinement measures due to the Covid-19 outbreak on the energy demand of seven residential archetype buildings in Greater London. Three levels of confinement for occupant schedules are proposed and compared with the base case before

Occupational Perspectives on Health in People with Schizophrenia

Popular Abstract in Swedish Denna avhandling har bidragit med systematisk information om hur personer med schizofreni lever sitt vardagsliv, och resultaten har visat på signifikanta relationer mellan ett aktivitetsperspektiv och hälsa. Avhandlingen består av fem studier. De första två är kvalitativa studier som handlar om tidsanvänding i förhållande till aktivitetsutförandet och aktivitetsengagemaThe thesis has provided with systematic information about how people with schizophrenia live their everyday life, and the results have shown significant relationships between occupational perspectives and health. The thesis departed in two in-depth studies that concerned time use and occupational engagement in relation to what people with schizophrenia do in their everyday life, with whom they are

Ritualization - Hybridization - Fragmentation : The Mutability of Roman Vessels in Germania Magna AD 1–400

This PhD thesis deals with the transformation of imported vessels of Roman origin in Germania Magna during the Roman Iron Age, 1-400 AD. The concept of transformation in this context refers to the various ways these objects were interpreted, physically altered and consequently changed with regard to their function and meaning. Roman vessels in Germanic contexts are often regarded as evidence for R

Hypertension, blood pressure, cognition and cerebral blood flow in the cohort of "Men born 1914"

Popular Abstract in Swedish Flertal studier talar för att såväl vaskulär demens som demens av Alzheimers typ är relaterade till blodtrycksnivå tidigare under livet. En studie har visat att redan blodtrycket vid 50- årsåldern är relaterat till kognitiva (intellektuella) funktioner vid 70-års ålder. En annan studie har visat att hypertoni i 70-årsåldern föregår utveckling av demens i ålder 80-85 år."Men born 1914" is a population based cohort study of the epidemiology of cardiovascular disease. Five hundred men, born 1914, were examined at the age of 68 and 185 of them were re-examined at 81 years of age. Examination included a medical and a psychological investigation, ultrasonographic measurement of carotid arteries, 24-hour ambulatory blood pressure monitoring, regional cerebral blood flo

Mesenchymal stromal cells in malignant glioma - Functions and therapeutic potential

The most common malignant brain tumor in adults is a glioma called glioblastoma multiforme (GBM). About 300 persons are diagnosed with GBM every year in Sweden. Unfortunately, it is also the most aggressive brain tumor and as of today, it is not possible to cure it. Despite treating the patients with surgery, radiation and chemotherapy, the median survival is only 15 months. The main problem with

Assistive Devices in Everyday Life for Very Old People - Use, Non-use and Opportunities for Use

The overarching aim of this thesis was to contribute to the existing knowledge on the use of assistive devices in everyday life, by adding the perspective of very old single living people in a European context, namely Latvia and Sweden. The aim was to investigate the socio-demographics and environmental and health aspects that impact on device use in the two national contexts. A further aim was to

Primary immunodeficiency in southern Sweden. Strategies for diagnosis and clinical management

Popular Abstract in Swedish Immunsystemet är ett invecklat och komplext system som finns överallt i kroppen och som inte är begränsat till ett enda organ. Vi utsätts hela tiden för ”angrepp” från mikro-organismer (t.ex. bakterier eller virus) men också för främmande ämnen som kan vara skadliga eller giftiga. Immunsystemets huvudfunktion är att hjälpa kroppen att känna igen dessa ”angripare” och atThe overall aim of this PhD project was to gain insight into the incidence of primary immunodeficiency (PID) in southern Sweden and to optimize diagnostic and treatment measures for these patients. We estimated the occurrence rate of PID in the pediatric population of southern Sweden during a period of 4 years and described the demographic, clinical and immunological characteristics of the identif

Skapa plats i landskapet : tidig- och mellanneolitiska samhällen utmed två västskånska dalgångar

Popular Abstract in SwedishDenna arkeologiska studie syftar till att förstå de neolitiska samhällenas framväxt, organisation och förändring kring de västskånska ådalgångarna vid Saxån-Välabäcken och Lödde å-Kävlingeån. Arkeologiska undersökningar och fornminnesinventeringen har visat att området hyser omfattande lämningar av neolitiska bebyggelsekomplex — i form av bosättningar, gravfält, megalitgThis dissertation deals with Early and Middle Neolithic societies in a valley landscape in western Scania, in the southern part of Sweden. Several archaeological excavations conducted by the National Heritage Board have revealed a great number of Neolithic remains in this region. The sites constitute a substantial continuous sequence from the earliest to the latest phase of the Funnel Beaker Cultu

Mesenchymal Stem Cells in Tumor Growth Inhibition and Cartilage Differentiation

The work presented in this thesis has been focused on mesenchymal stem cells (MSCs). In the two first studies, the effects of MSCs on tumor growth and development in vitro and in vivo was investigated. In the third study the expression of the integrins alpha10beta1 and alpha11beta1 on MSCs was characterized and the involvement of these two integrins in cartilage development was investigated in vit

Daily occupations among asylum seekers- Experience, performance and perception

Asylum seekers often find themselves in a situation where the structure and content of daily occupations have been disrupted and they might have limited access to paid work and education. Studies have shown that asylum seekers experience occupational depri- vation and a change in daily occupations which might even influence their identity. Such deprivation can eventually lead to dissatisfaction wi