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Requirements for the Induction of Adaptive Immune Responses to Rotavirus

Rotavirus (RV) infections remain the leading cause of world-wide diarrhea-associated morbidity and mortality among children <5 years of age. Despite the global introduction of RV vaccines over a decade ago, RV infections result in >200,000 deaths annually mostly in the low-income countries of Africa and Asia. Efficient clearance of the primary RV infection and protection from future re-infections

CRISPR Screens Identify Candidate Therapeutic Targets in Leukemia

Acute myeloid leukemia (AML) is a complex hematological malignancy marked by proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the persistence of leukemia stem cells (LSCs) after standard treatment, leading to relapse. This thesis employs in vivo CRISPR/Cas9 screening to investigate critical AML and LSC molecular mechanisms, interrogating the dependancies

Housing accessibility and participation among older adults with long-standing spinal cord injury

En stödjande miljö är centralt för att kunna upprätthålla ett självständigt liv och effektivt aktivitetsutförande, särskilt med ökande ålder. För personer med funktionella begränsningar, som konsekvenserna av en ryggmärgsskada, är balansen mellan personens funktionella kapacitet och miljöns krav av yttersta vikt för att kunna leva ett så välfungerande liv som möjligt. Livslängden efter en ryggmärg

Virus tropism and neutralization response in SIV infection

Popular Abstract in Swedish Sedan 1981, då de första fallen av AIDS beskrevs, har 25 miljoner människor dött på grund av att de har blivit smittade av immunbristviruset HIV . Det finns idag mer än 40 miljoner människor som lever med HIV eller AIDS. SIV är apsläktets variant på HIV och orsakar normalt ingen sjukdom hos sina värddjur som är olika afrikanska apor, men då asiatiska apor, t. ex. makakeSimian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. SIV use CCR5 and rarely CXCR4 but may use other coreceptors as alternatives. We have studied vi

Spending my time- Time use and meaningfulness in daily occupations as perceived by people with persistent mental illness

Engagement in daily occupations, especially those perceived as meaningful, is essential for health and well-being. According to evaluation reports, many individuals with persistent mental illness seem to lack meaningful everyday occupations. The aim of this thesis was to investigate possible relationships between occupation, operationalised as time use and daily rhythm in daily activities, among i

Let me be part of the plan - Experiences of information and information needs after colorectal cancer surgery

Popular Abstract in Swedish När patienten lämnar sjukhuset och återvänder hem efter en operation för kolorektal cancer (tjocktarm och ändtarm) innebär det en stor omställning. De är inte återställda efter den stora bukoperationen och upplever olika symtom som smärta, tarmbesvär och stor trötthet. Eftersom vårdtiderna blir allt kortare har deras återhämtning bara påbörjats på sjukhuset och de kommeThe overall aim of this thesis is to study the experiences of patients and next of kin with regard to information and information needs after being discharged after colorectal cancer surgery. The aim was also to study factors related to this. Different methods were combined in this explorative study in order to obtain diverse types of data. Patients who had undergone surgery for colorectal cancer

Housing Accessibility Methodology Targeting Older Poeple - Reliable Assessments and Valid Standards

Older people have more functional limitations than younger people and they form a segment of the population that is more dependent on mobility devices than other age groups. Since they spend most of their time at home, their dwelling is an important environmental arena for performing everyday activities. Barriers in the environment can limit or hinder activity performance. Therefore, older people

Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application

The introduction of L-DOPA pharmacotherapy revolutionized the treatment of Parkinson’s disease close to fifty years ago. Before the discovery of dopamine as a neurotransmitter and its involvement in the disease, these patients had very little aid from medication and were bound to a life without movement. The dopamine neurons in the midbrain are a key player in the circuitry that is responsible for

Distal Radius Fractures in the Elderly

This thesis combines quantitative, qualitative, and experimental approaches to address different aspects of distal radius fractures (DRFs) in the elderly.Study I was a registry-based cohort study of 5,536 DRF patients, of whom 259 (5%) sustained a concomitant distal metaphyseal ulna fracture. These patients, with a mean age of 73 years (SD 15), had nearly twice the odds of reporting severe symptom

Environmentally sustainable diets and human health - Nutritional adequacy, disease risk, and mortality

Introduction: Food systems strongly influence both human and planetary health. Unhealthy diets aremajor risk factors for chronic disease and mortality, while food production contributes substantially togreenhouse gas emissions (GHGE), and other negative environmental impacts. Adopting moresustainable dietary patterns, such as the EAT-Lancet diet, has been proposed as part of the solution, butuncer

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NYTT FRÅN SACO Vi har idag meddelat SLU att vi inte kan skriva på deras förslag till lokalt löneavtal och att vi därför, i enlighet med det centrala avtalet RALS-T, ge- mensamt ska begära stöd från de centrala parterna i syfte att nå en överenskommelse. Vi har i flera år krävt att arbetsgivare och fack gemensamt ska arbeta med de förberedande delar i det centrala löneavtalet RALS-T som ska klaras

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/slu/nyhetsbrev/nyhetsbrev_2020-12.pdf - 2026-05-10

A high-throughput pathology approach for further insight into the role of RBM3 as a biomarker of prognosis and chemotherapy response in human cancer

Popular Abstract in Swedish Allt fler människor drabbas av cancer, som idag är den ledande dödsorsaken globalt. De vanligaste cancerformerna i världen är lungcancer, bröstcancer och tjocktarmscancer och det är störst risk att dö i lungcancer, levercancer och magcancer. Även i Sverige ökar antalet cancerfall, till stor del på grund av att vi lever allt längre och cancer är idag en av våra stora folCancer incidence is increasing and it is the number one cause of death worldwide. Cancer is a highly heterogeneous disease and there is a great need for new early diagnostic, prognostic and treatment predictive biomarkers in order to improve patient outcomes. The RNA-binding motif protein 3, RBM3, is an emerging candidate biomarker of favourable prognosis and treatment response in several types of

LP3 Annual Report 2023

The “new” LP3 was created as a center in June 2016 by the Faculty of Science, the Faculty of Medicine and the Faculty of Engineering (LTH) by combining the “old” LP3, specialized in protein production, with LU’s protein crystallization facility. As part of the research infrastructure Protein Production Sweden (PPS), parts of LP3 are hosting and staffing the PPS Lund University node. LP3’s part in

https://www.lp3.lu.se/lp3-annual-report-2023 - 2026-05-09

Bacheng2016

Instructions for applicants to the Bachelor’s Programme in Fine Arts, 180 ECTS credits 2016/2017 Deadline for applications 23 February 2016 Deadlines and general information Applications to the Bachelor´s Programme in Fine Arts at Malmö Art Academy take place in two steps. First on Universityadmissions.se and then in the Malmö Art Academy application portal where work samples can be uploaded. You

https://www.khm.lu.se/en/sites/khm.lu.se.en/files/bacheng2016.pdf - 2026-05-10

Cps2017

Instructions for applicants to the Master of Fine Arts in Critical and Pedagogical Studies 120 ECTS credits 2017/2018 Deadline for applications 3 April 2017 Deadlines and general information v 1.0 Applications to the Master´s Programme in Fine Arts in Critical and Pedagogical Studies at Malmö Art Academy take place in two steps. First on Universityadmissions.se and then in the Malmö Art Academy ap

https://www.khm.lu.se/en/sites/khm.lu.se.en/files/cps2017.pdf - 2026-05-10

Bacheng2018

Instructions for applicants to the Bachelor’s Programme in Fine Arts, 180 ECTS credits 2018/2019 Deadline for applications 1 March 2018 v 1.0 Deadlines and general information Applications to the Bachelor´s Programme in Fine Arts at Malmö Art Academy take place in two steps. First on Universityadmissions.se and then in the Malmö Art Academy application portal where work samples can be uploaded. Yo

https://www.khm.lu.se/sites/khm.lu.se/files/bacheng2018.pdf - 2026-05-10

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Språk- och litteraturcentrum Franska Litteraturlista FRAM19, franska, Modern språkvetenskaplig teori med tillämpning på franska, 15 högskolepoäng Fastställd av Styrelsen för Sektion 3 2023-06-08 att gälla från HT2023 Obligatorisk litteratur Kleiber, Georges (1990). La sémantique du prototype. Paris: Presses universitaires de France. ISBN 9782130428374. Kapitel 1-4. (140 s.) Moeschler, Jacques & Re

https://www.sol.lu.se/media/utbildning/dokument/kurser/FRAM19/20242/FRAM19.pdf - 2026-05-09