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Objective: Fatigue is one of the most prevalent and distressing symptoms reported by survivors of childhood cancer. There is currently a lack of longitudinal studies on cancer-related fatigue, and especially on the relationship between the course of fatigue during treatment and fatigue at follow-up. The purpose of the current study was therefore to investigate if the course of fatigue during treat

Background: An understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), a

Background: Menière’s disease is an idiopathic disorder characterized by recurrent episodes of vertigo lasting more than 20 min, unilateral sensorineural hearing loss, and tinnitus. If vertigo attacks occur frequently, the patient is usually severely incapacitated. Currently, there is no consensus on the treatment of Menière’s disease. The evidence regarding most treatment options is sparse due to

The ongoing pursuit of advanced multicomponent magnetic nanomaterials with tailored functionalities for applications in data storage, spintronics, and biomedicine necessitates novel synthesis approaches beyond conventional template-based methods. In response, this thesis investigates the generation, self-assembly, and characterisation of largely little-known Fe0.10Ni0.40Co0.25Pt0.25 medium-entropy

Background.In some regions, including the Baltic Sea, fatty fish such as salmon and herring contain high levels of polychlorinated dibenzodioxins and dibenzofurans. We investigated human exposure to these potentially toxic substances in relation to the consumption of fish from the Baltic Sea.Methods.Plasma levels of 10 different dibenzofurans and 7 dioxins were analyzed in three groups of Swedish

In order to elucidate the multidimensional response mechanism for migration of antibiotics and spread of resistome in riverbed driven by river water level fluctuations, dynamic reactors were set up to simulate the variation of sulfamethazine vertical migration, biotransformation and resistance genes expression according to fluctuation direction and magnitude. The upward fluctuation of water level

Black carbon (BC) is produced by incomplete combustion of biomass and fossil fuels and is released as aerosols to the atmosphere with effects on the climate, environment, and human health. Current BC emissions are well monitored in many parts of the world. However, the geographical coverage is limited, and historical records of BC accumulation are still scarce. Here we present a quantification of

This work presents an alternative cetane rating method using a production compression ignition (CI) engine, offering an accessible approach for preliminary fuel evaluation without the need for specialized equipment. As part of this work, an empirical correlation was developed linking ignition delay (ID) to both the cetane number (CN) and intake oxygen concentration. The test method follows the pri

BackgroundThe captive bolt gun is a tool for stunning animals in the meat industry and is not considered a firearm under the Swedish firearm legislation. This study aimed to explore the involvement of such devices in human fatalities, with an emphasis on suicides. Epidemiological characteristics from a longitudinal perspective, as well as risk factors and injury patterns were analyzed.MethodSuicid

Background: Prolonged time to surgery (TTS) after neoadjuvant chemoradiotherapy (nCRT) may enable malnourished oesophageal cancer patients' nutritional status to recover better, possibly improving outcomes with fewer complications and better overall survival (OS) after oesophagectomy. Methods: This is a substudy within a multicentre randomised controlled trial comparing outcomes in patients with o

BackgroundBreathlessness is a common and distressing symptom across a wide range of medical conditions. Different aspects (dimensions) of breathlessness can be assessed using the Multidimensional Dyspnoea Profile (MDP) and Dyspnoea-12 (D12) questionnaires. We aimed to examine whether the order of completing MDP and D12 affects the breathlessness responses in people with cardiorespiratory disease.M

The efficiency and stability of wide bandgap (WBG) perovskite solar cells (PSCs) are constrained by photo-induced halide segregation and severe non-radiative recombination, which significantly impedes the advancement of high-efficiency and stable perovskite/silicon tandem solar cells (PSTSCs). In this work, a potassium 4-sulfonic-1,8-naphthalic anhydride salt (4S-NAPS), featuring dual-anchoring si

Purpose: This study aimed to evaluate the ability of a thigh-worn accelerometer to detect walking during daily life in individuals with Lumbar Spinal Stenosis (LSS). Two hypotheses were made regarding how walking measurements from the accelerometer, a walking test, and an ankle-worn StepWatch would relate in order for the accelerometer to be valid. The hypotheses were: (a) there is no difference b

Rubinstein–Taybi syndrome (RSTS) is a developmental disorder characterized by a typical face and distal limbs abnormalities, intellectual disability, and a vast number of other features. Two genes are known to cause RSTS, CREBBP in 60% and EP300 in 8–10% of clinically diagnosed cases. Both paralogs act in chromatin remodeling and encode for transcriptional co-activators interacting with >400 prote

Human metapneumovirus (hMPV) is associated with respiratory tract illness especially in young children. Two hMPV genetic lineages, A and B, and four sublineages A1, A2 and B1, B2 have been defined. Infection with hMPV occurs through membrane fusion mediated by the hMPV fusion (F) protein. In this study, the inter- and intra-patient genetic diversity of the lineage A hMPV F gene was investigated. T

Tau positron emission tomography ligands provide the novel possibility to image tau pathology in vivo. However, little is known about how in vivo brain uptake of tau positron emission tomography ligands relates to tau aggregates observed post-mortem. We performed tau positron emission tomography imaging with 18F-AV-1451 in three patients harbouring a p.R406W mutation in the MAPT gene, encoding tau