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The incidence of colorectal cancer (CRC) in young patients (≤50 years of age) appears to be increasing. However, their clinicopathological characteristics and survival are controversial. Likewise, the biomarkers are unclear. We used the West China (2008-2013, China), Surveillance, Epidemiology, and End Results program (1973-2011, United States) and Linköping Cancer (1972-2009, Sweden) databases to
To evaluate the accuracy of bone mineral composition determination by electron microprobe analysis (EDX) the measurements have been compared to instrumental neutron activation analysis (INAA) and chemical analysis (ICPES). Bone specimens from five femoral heads were used. The trabecular content of calcium (Ca) and phosphorus (P) was analyzed by the three different methods. The EDX method allows fo
The effect of moderate hypoglycemia (p-glucose, 2.0 +/- 0.3 mmol/L; mean +/- SD) on regional cerebral blood flow (rCBF) was studied in a group of 10 healthy, right-handed men (aged 23 to 28 years) using an intravenous xenon 133 single photon emission computed tomography technique (SPECT). After 10 minutes of hypoglycemia, global CBF had increased to 46.3 +/- 9.6 mL/100 g/min compared with the init
In this study, we examined the onset and duration of local analgesic effects of bupivacaine incorporated into biodegradable microcapsules (extended-duration local anesthetic; EDLA) administered as subcutaneous infiltrations in different doses in humans. In 18 volunteers, the skin on the medial calf was infiltrated with 10 mL of EDLA, and the opposite calf was infiltrated with 10 mL of aqueous bupi
Background and aims: Several studies report a high prevalence of memory complaints in the elderly, non-demented population. Since the pathogenesis and diversity of memory impairment in healthy people is still an unresolved issue, we designed our study to ascertain the occurrence of brain abnormalities in Age-Associated Memory Impairment (AAMI) by measuring regional cerebral blood flow (rCBF). Meth
Background: Improved diagnostics in suspected acute coronary syndrome (ACS) are considered to be needed. To help clarify the current situation and the improvement potential, judged risk in the emergency department (ED) and outcome were analyzed among patients with suspected ACS at a university hospital. Methods: 157 consecutive patients with symptoms of ACS were included at the ED during 10 days.
Biomolecular recognition is often characterised by low affinity where many weak interactions work either alone or in concert, resulting in an inherent dynamic situation. For example the well-studied weak binding of cell-cell interactions is predominantly based on a range of carbohydrates that interact with numerous (protein) ligands. Finding appropriate binders to these carbohydrate structures may
A monogenic inheritance, mainly seen as a dominant pattern, accounts for 5 - 10% of all cancer cases. The increased knowledge and identification of high-risk genes have led to a need for specialized cancer family clinic was the expression used by Eeles and Murday. The Oncogenetic Clinic at the University Hospital in Lund was started in 1993 and the authors' 10-year experience is summarized in this
It is widely accepted that the bioavaiiability, toxicity, and mobility of trace metals are highly dependent on complexation reactions with functional groups in natural organic matter (NOM). In this study, the coordination chemistry of Cd in NOM was investigated by extended X-ray absorption fine structure spectroscopy. Soil organic matter (SOM) from different types of organic soils and dissolved or
Lotta Granbom, a mother of three from Sweden is on holiday in Thailand. It is her first trip there together with her daughter Ebba-Lotta. After some difficulty finding accommodation at the tourist resorts, they decide instead to search for Sea Nomads in the Andaman Sea. Lotta has heard of a nomadic group of people who live on the sea around Thailand, Burma, Malaysia, Singapore, Philippines and Ind
Background. Dosimetry of the hypothalamus-pituitary (HP) region could allow prediction of the risk of growth hormone deficiency (GHD) following cranial irradiation. Procedure. Nineteen children (15 boys) with a median age of 6.3 years (range 1.7–16.5) at the time of irradiation of a brain tumor not involving the HP axis were followed for 1.2–6.3 years (median 3.4) from radiotherapy (RT). The dose
Popular Abstract in Swedish Cytokromer bär hem som prostetisk grupp och ingår i den energi givande andningskedjan. Cytokromer namnges beroende på strukturen av den hem-molekyl som respektive cytokrom bär. Cytokrom av a-typ innehåller hemA, cytokrom av b-typ innehåller hemB osv. Cytokrom av c-typ skiljer sig från övriga cytokrom genom att ha hemgruppen kovalent bunden till proteinet. Syntes av baktCytochromes function in electron transfer reactions, e.g. in respiratory systems, and contain haem as a prosthetic group. Cytochromes of the c-type differ from other cytochromes in that haem is covalently attached, via thioether linkages, to two cysteine residues in a conserved sequence motif in the protein, Cys-Xaa-Yaa-Cys-His. The functional location of c-type cytochromes in bacteria is on the o
We studied the impact of a family history of type 2 diabetes on physical fitness, lifestyle factors and diabetes-related metabolic factors. The Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study is a population-based study in Western Finland, which includes a random sample of 5,208 individuals aged 18 to 75 years identified through the national Finnish Population Registry. Physic
