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Programmable optical circuits form a key part of quantum technologies today. As the size of such circuits is increased, maintaining precise control over every individual component becomes challenging. Here we show how embedding an optical circuit in the higher-dimensional space of a large mode-mixer allows us to forgo control over individual elements, while retaining a high degree of programmabili
BACKGROUND: Treatment for breast cancer poses major challenges and leads to a variety of side-effects and problems that affect life for a long time. Experiences and symptoms vary, and research indicates a lack of structures for ensuring individualized rehabilitation. This qualitative focus group study aims to explore the experience of women with BC after participating in a complex randomized contr
Risk assessment constitutes a valuable tool for organizations responsible for critical societal functions in their effort of reducing the likelihood and mitigating the consequences of potentially harmful events. In a previous project, the researchers have contributed to the development and implementation of a method for risk assessment in the municipality of Malmö, Sweden. Shortly after the full-s
BACKGROUND: ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.METHODS: In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to pati
Background: Problem gambling and gambling disorder cause severe social, psychiatric, and financial consequences, and voluntary self-exclusion is a common harm reduction tool used by individuals with gambling problems. Objective: The aim of this study was to explore users’ experience of a novel nationwide, multioperator gambling self-exclusion service, “Spelpaus,” in Sweden and to inform stakeholde
Breast cancer is the most common type of cancer in women worldwide. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of the oestrogen receptor, progesterone receptor, and amplification of HER2. This subtype is the most aggressive subtype and a heterogeneous subgroup of breast cancer, making up around 10-15% of the cases, often affecting younger patients
We position recent and emerging research in cognitive vision and perception addressing three key questions: (1) What kind of relational abstraction mechanisms are needed to perform (explainable) grounded inference --e.g., question-answering, qualitative generalisation, hypothetical reasoning-- relevant to embodied multimodal interaction? (2) How can such abstraction mechanisms be founded on behavi
Patent Law is a legal field designed to promote technological innovation. Patent rights ensure exclusivity of rights to commercialize and explore innovation and in this sense are a fundamental mechanism to attract investment, ensure revenue streams and foster innovation. The relative relevance of patent rights depends on sectors of activity, business models and the nature of both the underlying in
Recent research projects have targeted the hitherto limited inclusion of the subsurface and its geo-resources in spatial planning in Sweden. The UNDER project focuses on the societal implications of using the concept of geosystem services to support planning practices. The concept of geosystem services has been described as the contributions to human well-being from the abiotic world or from the s
Aims/hypothesis: Systematic studies on the phenotypic consequences of variants causal of HNF1A-MODY are rare. Our aim was to assess the phenotype of carriers of a single HNF1A variant and genetic and clinical factors affecting the clinical spectrum. Methods: We conducted a family-based multigenerational study by comparing heterozygous carriers of the HNF1A p.(Gly292fs) variant with the non-carrier
Symptoms of vestibular dysfunction such as dizziness and vertigo are common following sports-related concussions (SRC) and associated with a worse outcome and a prolonged recovery. Vestibular dysfunction following SRC can be due to an impairment of the peripheral or central neural parts of the vestibular system. The aim of the present study was to establish the cause of vestibular impairment in SR
Background: We studied the association between cardiorenal function and survival, neurological outcome and trends in survival after in-hospital cardiac arrest (IHCA). Methods: We included cases aged ≥ 18 years in the Swedish Cardiopulmonary Resuscitation Registry during 2008 to 2020. The CKD-EPI equation was used to calculate estimated glomerular filtration rate (eGFR). A history of heart failure
Scanning coherent X-ray microscopy (ptychography) has gained considerable interest during the last decade since the performance of this indirect imaging technique does not necessarily rely on the quality of the X-ray optics and, in principle, can achieve highest spatial resolution in X-ray imaging. The method can be easily extended to 3D by adding standard tomographic reconstruction schemes. Howev
BACKGROUND: Calprotectin (S100A8/A9) is a pro-inflammatory mediator primarily released from neutrophils. Previous studies have revealed associations between plasma calprotectin, disease severity and in-hospital mortality in unselected COVID-19 patients.OBJECTIVE: We aimed to assess whether plasma calprotectin dynamics during the first week of intensive care are associated with mortality and functi
Digital breast tomosynthesis (DBT) has become a standard screening tool for breast cancer. However, its diagnostic performance is still limited compared to contrast-enhanced MRI, especially in women with dense breasts. Ultrafast dynamic contrast-enhanced (UF DCE) MRI and diffusion-weighted imaging (DWI) offer a shorter scanning time than conventional MRI and have shown promise in previous studies.
This chapter analyses the role that 'ordre public' and morality exceptions can play in the granting of patents on inventions in the field of human germline editing and the consequences of this policy option. In order to provide the context for such an analysis, the chapter will, first, provide an overview of the current patent landscape for relevant genome editing technologies, drawing attention t
Agriculture is key to sustainable development globally – particularly incountries where agriculture both accounts for most of the land use andprovides a livelihood for most of the population. We map out a collaborativeresearch agenda aimed at tackling the urgent but poorly understood issue ofthe role of farmer organisations in overcoming political barriers tosustainable and inclusive agricultural
Secondary lymphedema (LE) following breast cancer-related surgery is a life-long complication, which currently has no cure. LE induces significant regional adipose tissue deposition, requiring liposuction as a treatment. Here, we aimed to elucidate the transcriptional, metabolomic, and lipidomic signature of the adipose tissue developed due to the surgery-induced LE in short- and long-term LE pati
Contamination or damage to X-ray optics is becoming increasingly problematic for beamlines at 3rd and 4th generation storage-rings and FEL sources. Carbon contamination, induced by ultra-intense photon-beams, can cause a major loss in flux, focusing power, and specific absorptions which are detrimental to spectroscopy. For new light sources, with higher coherence, intensity, and repetition rates,
