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Immunotherapy is revolutionizing cancer treatment, but success is limited to a fraction of patients. Tumor immunosurveillance and immunotherapy relies on presentation of tumor-associated antigens by conventional dendritic cells type 1 (cDC1). However, tumors develop mechanisms to avoid immune recognition such as downregulation of antigen presentation and exclusion of cDC1. We have previously demon
Aims: Transforming growth factor-beta (TGF-β) exists in three isoforms TGF-β1, -β2, and -β3. TGF-β1 has been suggested to be important for maintaining plaque stability, yet the role of TGF-β2 and -β3 in atherosclerosis remains to be investigated. This study explores the association of the three isoforms of TGF-β with plaque stability in the human atherosclerotic disease. Methods and results: TGF-β
Tomographic X-ray imaging techniques offer novel opportunities for studying membranes and membrane processes in 3D on a spatial resolution not seen before. Traditional 2D imaging techniques used to characterise membranes have limitations that can be overcome by tomographic X-ray imaging. Tomographic X-ray imaging can provide information in 2D/3D or 4D (3D plus time) on membranes, membrane modules,
Plasma metabolomics holds potential for precision medicine, but limited information is available to compare the performance of such methods across multiple cohorts. We compared plasma metabolite profiles after an overnight fast in 11,309 participants of five population-based Swedish cohorts (50–80 years, 52% women). Metabolite profiles were uniformly generated at a core laboratory (Metabolon Inc.)
While organisms have evolved to cope with predictable changes in the environment, the rapid rate of current global change presents numerous novel and unpredictable stressors to which organisms have had less time to adapt. To persist in the urban environment, organisms must modify their physiology, morphology and behaviour accordingly. Metabolomics offers great potential for characterising organism
Oral assessment is an important method to evaluate the learning outcomes of scientific courses. However,there are certain limitations when oral assessment is applied.One of these limitations, which is not apparent in anonymous written exams, is the existence of biases which could lead to unfair (positive or negative) outcomes of the assessment. This could lead to decreased motivation and sense of
The purpose of the work was to investigate methods to achieve satisfaction with one’s own performance during and after a concert, using my own practice as point of departure. This has been investigated through interviews with musicians, continuous keeping of a logbook and literature studies. The goal was to be able to use the collected information to feel satisfied with my playing during my gradua
Lunds historia innehåller många medicinhistoriska händelser. Medicinhistoria som akademisk disciplin är dock inte endast deskriptiv utan även analyserande. Flera institutioner vid Lunds universitet bedriver medicinhistorisk forskning från olika utgångspunkter. Medicinhistoria är ett viktigt ämne för förståelsen av dagens medicin och denna översikt vill visa varför och hur ämnet behandlas vid Lunds
DevOps has significantly improved the software development life-cycle by enabling fast, automated, and continuous integration and deployment (CI/CD). However, its application to Cyber-Physical Systems (CPS) presents unique challenges that require rethinking of traditional practices. DevOps in CPS becomes even more challenging when we consider sustainability, which is becoming increasingly importan
Recessive diseases arise when both copies of a gene are impacted by a damaging genetic variant. When a patient carries two potentially causal variants in a gene, accurate diagnosis requires determining that these variants occur on different copies of the chromosome (that is, are in trans) rather than on the same copy (that is, in cis). However, current approaches for determining phase, beyond pare
Det hållbara arbete som idag utförs på olika enheter i staden ser ut att vara beroende av individers engagemang, snarare än deras kunskap kring vilka miljömål som ska uppnås av förvaltningen och vidare den specifika enheten. Osäkerheter bland medarbetarna kring; att de ska arbeta hållbart, vem som ansvarar för det hållbara arbetet, hur de ska arbeta hållbart samt vilka konsekvenser det får att arb
Vid marktekniska undersökningar i finkorniga jordar är det av stor vikt att korrekt kunna bestämma den odränerade skjuvhållfastheten. Detta görs idag vanligtvis ute i fält med en uppsjö av sonderingsmetoder som ger olika mått på hur fast jorden är. För homogena leror och sand finns det en stadig empirisk grund för hur dessa sonderingsparametrar räknas om till odränerad skjuvhållfasthet, men hur seThe undrained shear strength is a key parameter in the design process of geotechnical structures. One of the most frequently used methods to investigate this parameter is the cone penetration test (CPT). The CPT does not measure the undrained shear strength directly, but instead the resistance that a conic probe encounters as it is pushed into the ground. A calibration factor, the cone factor (Nkt
Den europeiska unionen tampas med låg folklig legitimitet, och hävdar många politiska bedömare, ett demokratiskt underskott. I det förhandenvarande arbetet, som är av normativ karaktär, tar sig författaren an detta ämne utifrån ett deltagardemokratiskt perspektiv, vilket han polemiserar mot ett elitdemokratiskt. Dessa demokratimodellers relationer till republikanismen och liberalismen redogörs där
Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate that FLT3 ITD, FLT3 N676K, and NRAS G12D accelerate KMT2A-MLLT3 leukemia onset. Further, also subclonal FLT3 N676K mutations accelerate
