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Linking social capital and mortality in the elderly: A Swedish national cohort study.
Our objective was to examine the association between neighborhood linking social capital (a concept describing the amount of trust between individuals and societal institutions) and all-cause and cause-specific mortality in the elderly.
Subsequent Risks of Parkinson Disease in Patients with Autoimmune and Related Disorders: A Nationwide Epidemiological Study from Sweden.
Objectives: To investigate associations between autoimmune disorders and Parkinson disease (PD), and to study whether the risk is associated with follow-up time and age. Methods: Standardized incidence ratios (SIRs) were calculated for PD in patients with autoimmune disorders by comparing them to subjects without autoimmune disorders. Results: Among 310,522 patients with a total of 33 conditions o
Familial Transmission of Venous Thromboembolism: A Cohort Study of 80,214 Swedish Adoptees Linked to Their Biological and Adoptive Parents.
-Venous thromboembolism (VTE) clusters in families, but the familial risk of VTE has not been determined among adoptees. The aim was to disentangle the contributions of genetic and environmental factors to the familial transmission of VTE.
Immigrants and Preterm Births: A Nationwide Epidemiological Study in Sweden.
To examine, nationwide, if there is an association between country of birth in mothers and preterm birth and to study whether any such association remains in second-generation immigrant women. In this follow-up study, a nationwide research database located at Lund University, Sweden, was used to identify all preterm born singletons in Sweden between January 1, 1982, and December 31, 2006. Incidenc
Effects of prescribed antihypertensives and other cardiovascular drugs on mortality in patients with atrial fibrillation and hypertension: a cohort study from Sweden.
Although antihypertensive drugs are known to reduce mortality in individuals with hypertension, the effects of different cardiovascular pharmacotherapies on mortality among patients with hypertension and atrial fibrillation (AF) have been less thoroughly explored. To study mortality rates in men and women separately with hypertension and AF prescribed different cardiovascular pharmacotherapies. A
Towards a systems-oriented framework for analysing and evaluating emergency response
Information can be provided by studying and evaluating past emergencies and the response in connection to them. This information would then be useful in efforts directed at preventing, mitigating and/or preparing for future emergencies. However, the analysis and evaluation of emergency response operations is not an easy task, especially when the operation involves several cooperating actors (e.g.
Risk and vulnerability analysis in practice: evaluation of analyses conducted in Swedish municipalities
isk and vulnerability analysis (RVA) can benefit the process of preventing and preparing for disasters, both by generating a basis for making decisions and by enhancing risk awareness, safety culture and response capacity through the RVA process itself. In studying and understanding the practices related to RVA, insights can be gained regarding ways in which the RVA can be improved in society, as
Objectively best or most acceptable? Expert and lay knowledge in Swedish wind power permit processes
This article analyses legal aspects of the Swedish wind power development, theoretically based on how different types of knowledge are represented in legal contexts, mainly in the courts. A sample of appealed wind power permits is analysed, a handful of relevant informants are interviewed – including two judges in the Land and Environment Court and the appeal court – and the legal setting is analy
Depression, stroke and gender: evidence of a stronger association in men.
Depression is associated with an increased risk for stroke. The aim of this study was to examine whether demographic and socioeconomic factors modify this association.
Sociodemographic Differences and Time Trends of Bariatric Surgery in Sweden 1990-2010.
The aim of the present study was to examine demographic and socioeconomic differences and time trends of bariatric surgery in Sweden during 1990-2010.
A Swedish national twin study of criminal behavior and its violent, white-collar and property subtypes.
We sought to clarify the etiological contribution of genetic and environmental factors to total criminal behavior (CB) measured as criminal convictions in men and women, and to violent (VCB), white-collar (WCCB) and property criminal behavior (PCB) in men only.
Familial Association of Inflammatory Bowel Diseases With Other Autoimmune and Related Diseases
OBJECTIVES: Familial risk estimates are useful for genetic counseling, etiological understanding, and design of gene identification studies. We wanted to estimate the associations of ulcerative colitis (UC) and Crohn's disease (CD) with 32 autoimmune and related diseases among parents and offspring, singleton siblings, twins, and spouses. METHODS: The Multigeneration Register in Sweden provides re
IQ and Schizophrenia in a Swedish National Sample: Their Causal Relationship and the Interaction of IQ With Genetic Risk.
The authors sought to clarify the relationship between IQ and subsequent risk for schizophrenia.
Proliferation of amyloid-beta 42 aggregates occurs through a secondary nucleation mechanism
The generation of toxic oligomers during the aggregation of the amyloid-beta (A beta) peptide A beta 42 into amyloid fibrils and plaques has emerged as a central feature of the onset and progression of Alzheimer's disease, but the molecular pathways that control pathological aggregation have proved challenging to identify. Here, we use a combination of kinetic studies, selective radiolabeling expe
Surface nanostructures for fluorescence probing of supported lipid bilayers on reflective substrates.
The fluorescence interference contrast (FLIC) effect prevents the use of fluorescence techniques to probe the continuity and fluidity of supported lipid bilayers on reflective materials due to a lack of detectable fluorescence. Here we show that adding nanostructures onto reflective surfaces to locally confer a certain distance between the deposited fluorophores and the reflecting surface enables
Gestational Age and Risk of Venous Thromboembolism From Birth Through Young Adulthood.
Preterm birth has been associated with increased risk of venous thromboembolism (VTE) in infancy, but the longer-term risk is unknown. Our aim was to examine this association from birth through young adulthood.
Invited commentary: Gene x lifestyle interactions and complex disease traits--inferring cause and effect from observational data, sine qua non.
Observational epidemiology has made outstanding contributions to the discovery and elucidation of relations between lifestyle factors and common complex diseases such as type 2 diabetes. Recent major advances in the understanding of the human genetics of this disease have inspired studies that seek to determine whether the risk conveyed by bona fide risk loci might be modified by lifestyle factors
Invasive pneumococcal disease in patients with an underlying pulmonary disorder.
Chronic pulmonary disease is a recognized risk factor for invasive pneumococcal disease (IPD). However, previous studies have often not been large enough to allow detailed analyses of less prevalent pulmonary diseases, and findings regarding case fatality have been inconsistent. We examined the associations between an underlying pulmonary disease and IPD, and the impact of these diseases on the ca
Using genetic variants to assess the relationship between circulating lipids and type 2 diabetes.
The effects of dyslipidemia on the risk of type 2 diabetes (T2D) and related traits are not clear. We used regression models and 140 lipid-associated genetic variants to estimate associations between circulating HDL-cholesterol, LDL-cholesterol and triglycerides, and T2D and related traits. Each genetic test was corrected for effects of variants on the other two lipid types and surrogates of adipo
