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OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis.

The objective of this work was to describe requirements for inclusion of soluble biomarkers in osteoarthritis (OA) clinical trials and progress toward OA-related biomarker qualification. The Guidelines for Biomarkers Working Group, representing experts in the field of OA biomarker research from both academia and industry, convened to discuss issues related to soluble biomarkers and to make recomme

Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual p

Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

Objective: Osteoarthritis (OA) is a chronic and slowly progressive disease for which biomarkers may be able to provide a more rapid indication of therapeutic responses to therapy than is currently available; this could accelerate and facilitate OA drug discovery and development programs. The goal of this document is to provide a summary and guide to the application of in vitro (biochemical and oth

Nanoscale imaging of local few-femtosecond near-field dynamics within a single plasmonic nanoantenna.

The local enhancement of few-cycle laser pulses by plasmonic nanostructures opens up for spatiotemporal control of optical interactions on a nanometer and few-femtosecond scale. However, spatially resolved characterization of few-cycle plasmon dynamics poses a major challenge due to the extreme length and time scales involved. In this letter, we experimentally demonstrate local variations in the d

Risk of transitional-cell carcinoma of the bladder in first- and second-generation immigrants to Sweden

Environmental risk factors, particularly tobacco smoking, are important for transitional-cell carcinoma of the bladder. Studies in migrants may provide valuable insight into the environmental and genetic etiology of cancer. The nationwide Swedish Family-Cancer Database was used to calculate standardized incidence ratios (SIRs) for transitional-cell carcinoma among the immigrants compared with nati

Development and Psychometric Evaluation of a New Instrument for Measuring Sleep Length and Television and Computer Habits of Swedish School-Age Children.

The aim was to develop a new instrument for measuring length of sleep as well as television and computer habits in school-age children. A questionnaire was constructed for use when children visit the school health care unit. Three aspects of the validity of the questionnaire were examined: its face validity, content validity, and construct validity. Test-retest reliability was assessed by giving t

Increased number and altered phenotype of lymphatic vessels in peripheral lung compartments of patients with COPD

Background: De novo lymphatic vessel formation has recently been observed in lungs of patients with moderate chronic obstructive pulmonary disease (COPD). However, the distribution of lymphatic vessel changes among the anatomical compartments of diseased lungs is unknown. Furthermore, information regarding the nature of lymphatic vessel alterations across different stages of COPD is missing. This

The complement system in systemic lupus erythematosus: an update.

The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Variou

The Accumulating Costs Hypothesis—to Better Understand Delayed “Hidden” Costs of Seemingly Mild Disease and Other Moderate Stressors

Mild diseases and moderate stressors are seemingly harmless and are therefore often assumed to have negligible impact on Darwinian fitness. Here we argue that the effects of “benign” parasites and other moderate stressors may have a greater impact on lifespan and other fitness traits than generally thought. We outline the “accumulating costs” hypothesis which proposes that moderate strains on the

Retinal regions shape human and murine Müller cell proteome profile and functionality

The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We compared proteomic data from cone- and rod-rich retinae from human and mice and identified different expression profiles of cone- and rod-associated Müller cells that converg

Restoring antitumor immunity with dendritic cell reprogramming strategies

A Ph.D. Interview with Alexandra Gabriela Barros Ferreira Alexandra Gabriela Barros Ferreira, a Ph.D. student at Lund University, is set to defend her thesis on Friday, 17 November 2023. Alexandra’s pursuit of scientific discovery has led her to focus on developing innovative strategies to combat cancer. Her research involves direct reprogramming approaches, which function like a Trojan horse, ena

https://www.stemcellcenter.lu.se/phd-interview-alexandra-ferreira - 2026-05-07

2 June 2022

From the Management Thank you everyone in the BBQ team for an excellently organized BBQ. The food, drinks, weather and company were just great! We are looking forward to meeting you all in person again in September, and in Teams for Friday info and fika already tomorrow. The external CIG(B) expert panel is proceeding their work of investigating how operations within CEC, INES and Geology could be

https://www.cec.lu.se/staff-pages/staff-newsletters/2-june-2022 - 2026-05-07

Advocating a capitalist welfare state

This article is over 5 years old, and the information may therefore be outdated. Economist and researcher Andreas Bergh is closely involved in public debate. Few things make him really angry. One of them is stupidity. Like when the city of Malmö fails to create simple entry-level jobs because of unreasonable demands on people who want to start mobile food trucks. “That is how the sluggish Swedish

https://www.staff.lu.se/article/advocating-capitalist-welfare-state - 2026-05-07

Sweah conference 22-24 oct 2019 program 0

SWEAH Conference October 22-24, 2019, Lund, Sweden Preliminary program Tuesday, October 22, 2019 13.00-15.00 Pre-conference meeting for partner representatives and supervisors 15.00-16.00 Registration for the conference 16.00-16.15 Welcome to the SWEAH conference! Margareta Pålsson, Chair of the SWEAH board Moderators: Catharina Melander & Joakim Frögren 16.15 -17.00 Key Note Presentation Ethnicit

https://www.sweah.lu.se/en/sites/sweah.lu.se.en/files/sweah_conference_22-24_oct_2019_program_0.pdf - 2026-05-08

Sweah conference 22-24 oct 2019 program 4

SWEAH Conference October 22-24, 2019, Lund, Sweden Preliminary program Tuesday, October 22, 2019 13.00-15.00 Pre-conference meeting for partner representatives and supervisors 15.00-16.00 Registration for the conference 16.00-16.15 Welcome to the SWEAH conference! Margareta Pålsson, Chair of the SWEAH board Moderators: Catharina Melander & Joakim Frögren 16.15 -17.00 Key Note Presentation Ethnicit

https://www.sweah.lu.se/en/sites/sweah.lu.se.en/files/sweah_conference_22-24_oct_2019_program_4.pdf - 2026-05-08

Sweah conference 22-24 oct 2019 program 6

SWEAH Conference October 22-24, 2019, Lund, Sweden Preliminary program Tuesday, October 22, 2019 13.00-15.00 Pre-conference meeting for partner representatives and supervisors Supervising the doctorate in a multidisciplinary context: opportunities and challenges Sandra Torres, Professor of Sociology, Uppsala University 15.00-16.00 Coffee and registration for the conference 16.00-16.15 Welcome to t

https://www.sweah.lu.se/en/sites/sweah.lu.se.en/files/sweah_conference_22-24_oct_2019_program_6.pdf - 2026-05-08

Sweah conference 22-24 oct 2019 program 8

SWEAH Conference October 22-24, 2019, Lund, Sweden Preliminary program Tuesday, October 22, 2019 13.00-15.00 Pre-conference meeting for partner representatives and supervisors Supervising the doctorate in a multidisciplinary context: opportunities and challenges Sandra Torres, Professor of Sociology, Uppsala University 15.00-16.00 Coffee and registration for the conference 16.00-16.15 Welcome to t

https://www.sweah.lu.se/en/sites/sweah.lu.se.en/files/sweah_conference_22-24_oct_2019_program_8.pdf - 2026-05-08

Sweah conference 22-24 oct 2019 program

SWEAH Conference October 22-24, 2019, Lund, Sweden Preliminary program Tuesday, October 22, 2019 13.00-15.00 Pre-conference meeting for partner representatives and supervisors 15.00-16.00 Registration for the conference 16.00-16.15 Welcome to the SWEAH conference! Margareta Pålsson, Chair of the SWEAH board Moderators: Catharina Melander & Joakim Frögren 16.15 -17.00 Key Note Presentation Ethnicit

https://www.sweah.lu.se/en/sites/sweah.lu.se.en/files/sweah_conference_22-24_oct_2019_program.pdf - 2026-05-08